Clinical significance of proliferation index and E-cadherin expression in colorectal adenocarcinoma

Introduction/Objective. The aim of this study is to examine the association of E-cadherin expression and high proliferation index (proIDX) with clinical and pathological indicators of colorectal cancer progression. Methods. The biopsy of 72 patients, obtained by resection of colorectal cancer, was r...

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Autores principales:	Žujović Janko, Vuletić Milena, Stojanović Miroslav, Lazović Ranko, Đorđević Nebojša, Radunović Miodrag, Jančić Snežana, Milošević Velimir
Formato:	article
Lenguaje:	EN SR
Publicado:	Serbian Medical Society 2021
Materias:	colorectal cancer e-cadherin expression proliferative index clinical significance Medicine R
Acceso en línea:	https://doaj.org/article/ed2b6915671d4708b0453ddffeca4c1b
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spelling	oai:doaj.org-article:ed2b6915671d4708b0453ddffeca4c1b2021-11-10T07:28:09ZClinical significance of proliferation index and E-cadherin expression in colorectal adenocarcinoma0370-81792406-089510.2298/SARH200929055Zhttps://doaj.org/article/ed2b6915671d4708b0453ddffeca4c1b2021-01-01T00:00:00Zhttp://www.doiserbia.nb.rs/img/doi/0370-8179/2021/0370-81792100055Z.pdfhttps://doaj.org/toc/0370-8179https://doaj.org/toc/2406-0895Introduction/Objective. The aim of this study is to examine the association of E-cadherin expression and high proliferation index (proIDX) with clinical and pathological indicators of colorectal cancer progression. Methods. The biopsy of 72 patients, obtained by resection of colorectal cancer, was routinely processed at the Institute of Pathology of the Clinical Centre of Montenegro, embedded in paraffin and archived. Based on the archived pathohistological reports, two study groups were formed: the first group (n = 72) consisted of operative biopsies of colorectal cancer, and the control group (n = 72) consisted of biopsies of adjacent non-tumor tissue. Routine hematoxylin-eosin and immunohistochemical avidin-biotin-peroxidase complex method with anti-Ki67 and anti-E-cadherin antibodies was applied on. After quantification of the results for statistical tests, the software package SPSS for Windows (19.0) was used. Results. In colorectal carcinoma, we observed a significant association of proIDX with pT stage, lymph and blood vessel invasion, perineural invasion, lymph node metastases and distant metastases, and Astler–Coller stage tumor disease. We also observed that the absence of E-cadherin was significantly associated with pT stage, lymph and blood vessel invasion, perineural invasion with lymph node metastases, distant metastases, with C2 and D Astler–Coller tumor stage. E-cadherin expression is associated with proIDX with a significantly high, negative correlation coefficient. Conclusion. Our results indicate that it is possible to differentiate patients into groups with a higher or lower risk of developing metastatic disease, based on the expression of Ki67 and E-cadherin.Žujović JankoVuletić MilenaStojanović MiroslavLazović RankoĐorđević NebojšaRadunović MiodragJančić SnežanaMilošević VelimirSerbian Medical Societyarticlecolorectal cancere-cadherin expressionproliferative indexclinical significanceMedicineRENSRSrpski Arhiv za Celokupno Lekarstvo, Vol 149, Iss 9-10, Pp 558-565 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	colorectal cancer e-cadherin expression proliferative index clinical significance Medicine R
spellingShingle	colorectal cancer e-cadherin expression proliferative index clinical significance Medicine R Žujović Janko Vuletić Milena Stojanović Miroslav Lazović Ranko Đorđević Nebojša Radunović Miodrag Jančić Snežana Milošević Velimir Clinical significance of proliferation index and E-cadherin expression in colorectal adenocarcinoma
description	Introduction/Objective. The aim of this study is to examine the association of E-cadherin expression and high proliferation index (proIDX) with clinical and pathological indicators of colorectal cancer progression. Methods. The biopsy of 72 patients, obtained by resection of colorectal cancer, was routinely processed at the Institute of Pathology of the Clinical Centre of Montenegro, embedded in paraffin and archived. Based on the archived pathohistological reports, two study groups were formed: the first group (n = 72) consisted of operative biopsies of colorectal cancer, and the control group (n = 72) consisted of biopsies of adjacent non-tumor tissue. Routine hematoxylin-eosin and immunohistochemical avidin-biotin-peroxidase complex method with anti-Ki67 and anti-E-cadherin antibodies was applied on. After quantification of the results for statistical tests, the software package SPSS for Windows (19.0) was used. Results. In colorectal carcinoma, we observed a significant association of proIDX with pT stage, lymph and blood vessel invasion, perineural invasion, lymph node metastases and distant metastases, and Astler–Coller stage tumor disease. We also observed that the absence of E-cadherin was significantly associated with pT stage, lymph and blood vessel invasion, perineural invasion with lymph node metastases, distant metastases, with C2 and D Astler–Coller tumor stage. E-cadherin expression is associated with proIDX with a significantly high, negative correlation coefficient. Conclusion. Our results indicate that it is possible to differentiate patients into groups with a higher or lower risk of developing metastatic disease, based on the expression of Ki67 and E-cadherin.
format	article
author	Žujović Janko Vuletić Milena Stojanović Miroslav Lazović Ranko Đorđević Nebojša Radunović Miodrag Jančić Snežana Milošević Velimir
author_facet	Žujović Janko Vuletić Milena Stojanović Miroslav Lazović Ranko Đorđević Nebojša Radunović Miodrag Jančić Snežana Milošević Velimir
author_sort	Žujović Janko
title	Clinical significance of proliferation index and E-cadherin expression in colorectal adenocarcinoma
title_short	Clinical significance of proliferation index and E-cadherin expression in colorectal adenocarcinoma
title_full	Clinical significance of proliferation index and E-cadherin expression in colorectal adenocarcinoma
title_fullStr	Clinical significance of proliferation index and E-cadherin expression in colorectal adenocarcinoma
title_full_unstemmed	Clinical significance of proliferation index and E-cadherin expression in colorectal adenocarcinoma
title_sort	clinical significance of proliferation index and e-cadherin expression in colorectal adenocarcinoma
publisher	Serbian Medical Society
publishDate	2021
url	https://doaj.org/article/ed2b6915671d4708b0453ddffeca4c1b
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Clinical significance of proliferation index and E-cadherin expression in colorectal adenocarcinoma

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