Expression-based drug screening of neural progenitor cells from individuals with schizophrenia

Unbiased large scale screening of small molecules for drug discovery in psychiatric disease is technically challenging and financially costly. Here, Readhead and colleagues integrate in silico and in vitro approaches to design and conduct transcriptomic drug screening in schizophrenia patient-derive...

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Autores principales:	Benjamin Readhead, Brigham J. Hartley, Brian J. Eastwood, David A. Collier, David Evans, Richard Farias, Ching He, Gabriel Hoffman, Pamela Sklar, Joel T. Dudley, Eric E. Schadt, Radoslav Savić, Kristen J. Brennand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ed2d9e5658de4fa6b0313e02ddefca0f
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spelling	oai:doaj.org-article:ed2d9e5658de4fa6b0313e02ddefca0f2021-12-02T15:34:22ZExpression-based drug screening of neural progenitor cells from individuals with schizophrenia10.1038/s41467-018-06515-42041-1723https://doaj.org/article/ed2d9e5658de4fa6b0313e02ddefca0f2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06515-4https://doaj.org/toc/2041-1723Unbiased large scale screening of small molecules for drug discovery in psychiatric disease is technically challenging and financially costly. Here, Readhead and colleagues integrate in silico and in vitro approaches to design and conduct transcriptomic drug screening in schizophrenia patient-derived neural cells, in order to survey novel pathologies and points of intervention.Benjamin ReadheadBrigham J. HartleyBrian J. EastwoodDavid A. CollierDavid EvansRichard FariasChing HeGabriel HoffmanPamela SklarJoel T. DudleyEric E. SchadtRadoslav SavićKristen J. BrennandNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin Readhead Brigham J. Hartley Brian J. Eastwood David A. Collier David Evans Richard Farias Ching He Gabriel Hoffman Pamela Sklar Joel T. Dudley Eric E. Schadt Radoslav Savić Kristen J. Brennand Expression-based drug screening of neural progenitor cells from individuals with schizophrenia
description	Unbiased large scale screening of small molecules for drug discovery in psychiatric disease is technically challenging and financially costly. Here, Readhead and colleagues integrate in silico and in vitro approaches to design and conduct transcriptomic drug screening in schizophrenia patient-derived neural cells, in order to survey novel pathologies and points of intervention.
format	article
author	Benjamin Readhead Brigham J. Hartley Brian J. Eastwood David A. Collier David Evans Richard Farias Ching He Gabriel Hoffman Pamela Sklar Joel T. Dudley Eric E. Schadt Radoslav Savić Kristen J. Brennand
author_facet	Benjamin Readhead Brigham J. Hartley Brian J. Eastwood David A. Collier David Evans Richard Farias Ching He Gabriel Hoffman Pamela Sklar Joel T. Dudley Eric E. Schadt Radoslav Savić Kristen J. Brennand
author_sort	Benjamin Readhead
title	Expression-based drug screening of neural progenitor cells from individuals with schizophrenia
title_short	Expression-based drug screening of neural progenitor cells from individuals with schizophrenia
title_full	Expression-based drug screening of neural progenitor cells from individuals with schizophrenia
title_fullStr	Expression-based drug screening of neural progenitor cells from individuals with schizophrenia
title_full_unstemmed	Expression-based drug screening of neural progenitor cells from individuals with schizophrenia
title_sort	expression-based drug screening of neural progenitor cells from individuals with schizophrenia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ed2d9e5658de4fa6b0313e02ddefca0f
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Expression-based drug screening of neural progenitor cells from individuals with schizophrenia

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