Branham sign in dogs undergoing interventional patent ductus arteriosus occlusion or surgical ligation: A retrospective study

Background: The Branham sign is a baroreceptor response that follows patent ductus arteriosus (PDA) closure. Although described in dogs following both interventional and surgical ductal closure, a direct comparison of the Branham sign elicited by these two techniques has not been made. Aim: Since...

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Autores principales:	Filipe L. Madruga, Yolanda Martinez Pereira, Ambra Panti, Ian Handel, Geoff Culshaw
Formato:	article
Lenguaje:	EN
Publicado:	Tripoli University 2021
Materias:	acdo branham sign dog ligation pda Zoology QL1-991
Acceso en línea:	https://doaj.org/article/ed2fa078394943478f3e6c7f01b6487e
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spelling	oai:doaj.org-article:ed2fa078394943478f3e6c7f01b6487e2021-11-16T19:45:48ZBranham sign in dogs undergoing interventional patent ductus arteriosus occlusion or surgical ligation: A retrospective study10.5455/OVJ.2021.v11.i4.102226-44852218-6050https://doaj.org/article/ed2fa078394943478f3e6c7f01b6487e2021-11-01T00:00:00Zhttps://www.openveterinaryjournal.com/OVJ-2021-06-108%20F.L.%20Madruga%20et%20al.pdfhttps://doaj.org/toc/2226-4485https://doaj.org/toc/2218-6050Background: The Branham sign is a baroreceptor response that follows patent ductus arteriosus (PDA) closure. Although described in dogs following both interventional and surgical ductal closure, a direct comparison of the Branham sign elicited by these two techniques has not been made. Aim: Since closure with an Amplatz canine ductal occluder (ACDO) occurs over 10 minutes and surgical ligation (SL) is more rapid, we hypothesised that the Branham sign following occlusion of a PDA with an ACDO would be less severe than following SL. Methods: Clinical records of dogs diagnosed with left-to-right shunting PDA between 2008 and 2018 were retrospectively reviewed. Of 139 dogs undergoing PDA occlusion, only 41 dogs (ACDO n = 32, SL n = 9) were included after applying exclusion criteria. Heart rate and BP from occlusion time (T0) until thirty minutes post occlusion (T30) were recorded. Signalment and anaesthetic protocol were also recorded. The influence of age and weight on the haemodynamic variations was assessed. Haemodynamic variables and calculations were compared between and within groups using a repeated measures general linear model, and post hoc tests were applied if significance was identified. Results: A mild Branham sign was present in both groups, and haemodynamic changes were not significantly different between groups. In both groups, there was a significant decrease in HR (11 bpm, 5.3 – 16.3; p < 0.001) (10.4 %, 5.4 – 15.5; p < 0.001) and increase in diastolic BP (9.5 mmHg, 3 – 16; p = 0.002) (23.5 %, 7.1 – 39.9; p = 0.002), but systolic BP did not change significantly (p = 0.824). Age and weight did not influence Branham sign. Conclusion: The Branham sign in dogs is mild in both groups, lasts for at least 30 minutes, and is independent of the method of PDA closure. Filipe L. MadrugaYolanda Martinez PereiraAmbra PantiIan HandelGeoff CulshawTripoli Universityarticleacdobranham signdogligationpdaZoologyQL1-991ENOpen Veterinary Journal, Vol 11, Iss 4, Pp 603-612 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acdo branham sign dog ligation pda Zoology QL1-991
spellingShingle	acdo branham sign dog ligation pda Zoology QL1-991 Filipe L. Madruga Yolanda Martinez Pereira Ambra Panti Ian Handel Geoff Culshaw Branham sign in dogs undergoing interventional patent ductus arteriosus occlusion or surgical ligation: A retrospective study
description	Background: The Branham sign is a baroreceptor response that follows patent ductus arteriosus (PDA) closure. Although described in dogs following both interventional and surgical ductal closure, a direct comparison of the Branham sign elicited by these two techniques has not been made. Aim: Since closure with an Amplatz canine ductal occluder (ACDO) occurs over 10 minutes and surgical ligation (SL) is more rapid, we hypothesised that the Branham sign following occlusion of a PDA with an ACDO would be less severe than following SL. Methods: Clinical records of dogs diagnosed with left-to-right shunting PDA between 2008 and 2018 were retrospectively reviewed. Of 139 dogs undergoing PDA occlusion, only 41 dogs (ACDO n = 32, SL n = 9) were included after applying exclusion criteria. Heart rate and BP from occlusion time (T0) until thirty minutes post occlusion (T30) were recorded. Signalment and anaesthetic protocol were also recorded. The influence of age and weight on the haemodynamic variations was assessed. Haemodynamic variables and calculations were compared between and within groups using a repeated measures general linear model, and post hoc tests were applied if significance was identified. Results: A mild Branham sign was present in both groups, and haemodynamic changes were not significantly different between groups. In both groups, there was a significant decrease in HR (11 bpm, 5.3 – 16.3; p < 0.001) (10.4 %, 5.4 – 15.5; p < 0.001) and increase in diastolic BP (9.5 mmHg, 3 – 16; p = 0.002) (23.5 %, 7.1 – 39.9; p = 0.002), but systolic BP did not change significantly (p = 0.824). Age and weight did not influence Branham sign. Conclusion: The Branham sign in dogs is mild in both groups, lasts for at least 30 minutes, and is independent of the method of PDA closure.
format	article
author	Filipe L. Madruga Yolanda Martinez Pereira Ambra Panti Ian Handel Geoff Culshaw
author_facet	Filipe L. Madruga Yolanda Martinez Pereira Ambra Panti Ian Handel Geoff Culshaw
author_sort	Filipe L. Madruga
title	Branham sign in dogs undergoing interventional patent ductus arteriosus occlusion or surgical ligation: A retrospective study
title_short	Branham sign in dogs undergoing interventional patent ductus arteriosus occlusion or surgical ligation: A retrospective study
title_full	Branham sign in dogs undergoing interventional patent ductus arteriosus occlusion or surgical ligation: A retrospective study
title_fullStr	Branham sign in dogs undergoing interventional patent ductus arteriosus occlusion or surgical ligation: A retrospective study
title_full_unstemmed	Branham sign in dogs undergoing interventional patent ductus arteriosus occlusion or surgical ligation: A retrospective study
title_sort	branham sign in dogs undergoing interventional patent ductus arteriosus occlusion or surgical ligation: a retrospective study
publisher	Tripoli University
publishDate	2021
url	https://doaj.org/article/ed2fa078394943478f3e6c7f01b6487e
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Branham sign in dogs undergoing interventional patent ductus arteriosus occlusion or surgical ligation: A retrospective study

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