The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

Non-resolving bacterial pneumonia results in lung tissue damage owing to overactive inflammation. Here the authors show that the mitochondrial DAMP cardiolipin contributes to persistent inflammation by SUMOylating PPARγ, which promotes binding of the corepressor NCOR/HDAC3 complex to the IL-10 promo...

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Autores principales:	Krishnendu Chakraborty, Mahesh Raundhal, Bill B. Chen, Christina Morse, Yulia Y. Tyurina, Anupriya Khare, Timothy B. Oriss, Rachael Huff, Janet S. Lee, Claudette M. St. Croix, Simon Watkins, Rama K. Mallampalli, Valerian E. Kagan, Anuradha Ray, Prabir Ray
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ed3074f4d02046868003319cc7c6eaff
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spelling	oai:doaj.org-article:ed3074f4d02046868003319cc7c6eaff2021-12-02T14:42:03ZThe mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia10.1038/ncomms139442041-1723https://doaj.org/article/ed3074f4d02046868003319cc7c6eaff2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13944https://doaj.org/toc/2041-1723Non-resolving bacterial pneumonia results in lung tissue damage owing to overactive inflammation. Here the authors show that the mitochondrial DAMP cardiolipin contributes to persistent inflammation by SUMOylating PPARγ, which promotes binding of the corepressor NCOR/HDAC3 complex to the IL-10 promoter.Krishnendu ChakrabortyMahesh RaundhalBill B. ChenChristina MorseYulia Y. TyurinaAnupriya KhareTimothy B. OrissRachael HuffJanet S. LeeClaudette M. St. CroixSimon WatkinsRama K. MallampalliValerian E. KaganAnuradha RayPrabir RayNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Krishnendu Chakraborty Mahesh Raundhal Bill B. Chen Christina Morse Yulia Y. Tyurina Anupriya Khare Timothy B. Oriss Rachael Huff Janet S. Lee Claudette M. St. Croix Simon Watkins Rama K. Mallampalli Valerian E. Kagan Anuradha Ray Prabir Ray The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia
description	Non-resolving bacterial pneumonia results in lung tissue damage owing to overactive inflammation. Here the authors show that the mitochondrial DAMP cardiolipin contributes to persistent inflammation by SUMOylating PPARγ, which promotes binding of the corepressor NCOR/HDAC3 complex to the IL-10 promoter.
format	article
author	Krishnendu Chakraborty Mahesh Raundhal Bill B. Chen Christina Morse Yulia Y. Tyurina Anupriya Khare Timothy B. Oriss Rachael Huff Janet S. Lee Claudette M. St. Croix Simon Watkins Rama K. Mallampalli Valerian E. Kagan Anuradha Ray Prabir Ray
author_facet	Krishnendu Chakraborty Mahesh Raundhal Bill B. Chen Christina Morse Yulia Y. Tyurina Anupriya Khare Timothy B. Oriss Rachael Huff Janet S. Lee Claudette M. St. Croix Simon Watkins Rama K. Mallampalli Valerian E. Kagan Anuradha Ray Prabir Ray
author_sort	Krishnendu Chakraborty
title	The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia
title_short	The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia
title_full	The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia
title_fullStr	The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia
title_full_unstemmed	The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia
title_sort	mito-damp cardiolipin blocks il-10 production causing persistent inflammation during bacterial pneumonia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ed3074f4d02046868003319cc7c6eaff
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The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

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