TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses
Acquisition of dying tumor cell-associated antigens is an essential step for the initiation of anti-tumor immune response by conventional type 1 dendritic cells (cDC1). Here the authors show that the loss of TIM4 expression in lung tumor associated cDC1 is associated with less efficient uptake of ce...
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Nature Portfolio
2021
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oai:doaj.org-article:ed313efe49174e4e8c4bd8e1699650812021-12-02T14:30:27ZTIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses10.1038/s41467-021-22535-z2041-1723https://doaj.org/article/ed313efe49174e4e8c4bd8e1699650812021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22535-zhttps://doaj.org/toc/2041-1723Acquisition of dying tumor cell-associated antigens is an essential step for the initiation of anti-tumor immune response by conventional type 1 dendritic cells (cDC1). Here the authors show that the loss of TIM4 expression in lung tumor associated cDC1 is associated with less efficient uptake of cell associated antigens and reduction of CD8 + T cell activation in advanced lung tumors.Nicoletta CaronniGiulia Maria PipernoFrancesca SimoncelloOriana RomanoSimone VodretYuichi YanagihashiRegine DressCharles-Antoine DutertreMattia BugattiPierre BourdeleyAnnalisa Del PreteTiziana SchioppaEmilia Maria Cristina MazzaLicio CollavinSerena ZacchignaRenato OstuniPierre GuermonprezWilliam VermiFlorent GinhouxSilvio BicciatoShigekatzu NagataFederica BenvenutiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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DOAJ |
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| topic |
Science Q |
| spellingShingle |
Science Q Nicoletta Caronni Giulia Maria Piperno Francesca Simoncello Oriana Romano Simone Vodret Yuichi Yanagihashi Regine Dress Charles-Antoine Dutertre Mattia Bugatti Pierre Bourdeley Annalisa Del Prete Tiziana Schioppa Emilia Maria Cristina Mazza Licio Collavin Serena Zacchigna Renato Ostuni Pierre Guermonprez William Vermi Florent Ginhoux Silvio Bicciato Shigekatzu Nagata Federica Benvenuti TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses |
| description |
Acquisition of dying tumor cell-associated antigens is an essential step for the initiation of anti-tumor immune response by conventional type 1 dendritic cells (cDC1). Here the authors show that the loss of TIM4 expression in lung tumor associated cDC1 is associated with less efficient uptake of cell associated antigens and reduction of CD8 + T cell activation in advanced lung tumors. |
| format |
article |
| author |
Nicoletta Caronni Giulia Maria Piperno Francesca Simoncello Oriana Romano Simone Vodret Yuichi Yanagihashi Regine Dress Charles-Antoine Dutertre Mattia Bugatti Pierre Bourdeley Annalisa Del Prete Tiziana Schioppa Emilia Maria Cristina Mazza Licio Collavin Serena Zacchigna Renato Ostuni Pierre Guermonprez William Vermi Florent Ginhoux Silvio Bicciato Shigekatzu Nagata Federica Benvenuti |
| author_facet |
Nicoletta Caronni Giulia Maria Piperno Francesca Simoncello Oriana Romano Simone Vodret Yuichi Yanagihashi Regine Dress Charles-Antoine Dutertre Mattia Bugatti Pierre Bourdeley Annalisa Del Prete Tiziana Schioppa Emilia Maria Cristina Mazza Licio Collavin Serena Zacchigna Renato Ostuni Pierre Guermonprez William Vermi Florent Ginhoux Silvio Bicciato Shigekatzu Nagata Federica Benvenuti |
| author_sort |
Nicoletta Caronni |
| title |
TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses |
| title_short |
TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses |
| title_full |
TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses |
| title_fullStr |
TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses |
| title_full_unstemmed |
TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses |
| title_sort |
tim4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ed313efe49174e4e8c4bd8e169965081 |
| work_keys_str_mv |
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