Small cell transformation in crizotinib‐resistant ROS1‐rearranged non‐small cell lung cancer with retention of ROS1 fusion: A case report

Abstract C‐ros oncogene 1 receptor tyrosine kinase (ROS1) rearrangement has been detected in patients with advanced non‐small cell lung cancer (NSCLC). Although ROS1 tyrosine kinase inhibitors (TKIs) provide a survival benefit for patients with ROS1‐rearranged advanced NSCLC, subsequent therapy rema...

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Autores principales:	Chi‐Hao Wu, Po‐Lan Su, Che‐Wei Hsu, Chang‐Yao Chu, Chien‐Chung Lin
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	adenocarcinoma ROS1 rearrangement small cell transformation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ed32ab372512427db583dba7cab3a7cf
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spelling	oai:doaj.org-article:ed32ab372512427db583dba7cab3a7cf2021-11-14T23:28:26ZSmall cell transformation in crizotinib‐resistant ROS1‐rearranged non‐small cell lung cancer with retention of ROS1 fusion: A case report1759-77141759-770610.1111/1759-7714.14175https://doaj.org/article/ed32ab372512427db583dba7cab3a7cf2021-11-01T00:00:00Zhttps://doi.org/10.1111/1759-7714.14175https://doaj.org/toc/1759-7706https://doaj.org/toc/1759-7714Abstract C‐ros oncogene 1 receptor tyrosine kinase (ROS1) rearrangement has been detected in patients with advanced non‐small cell lung cancer (NSCLC). Although ROS1 tyrosine kinase inhibitors (TKIs) provide a survival benefit for patients with ROS1‐rearranged advanced NSCLC, subsequent therapy remains limited. Small cell transformation is an important mechanism of drug resistance in epidermal growth factor receptor‐mutant NSCLC. However, its significance in mediating ROS1 resistance has not been determined yet. Here, we present the case of a 63‐year‐old man with ROS1‐rearranged advanced NSCLC who had disease progression with small cell transformation of the mediastinal lymph node after 8 months of treatment with crizotinib. More importantly, fluorescence in situ hybridization of post‐progression tumor biopsy demonstrated retention of ROS1 rearrangement. Tissue biopsy remains indispensable for patients who acquire resistance to ROS1 TKIs.Chi‐Hao WuPo‐Lan SuChe‐Wei HsuChang‐Yao ChuChien‐Chung LinWileyarticleadenocarcinomaROS1 rearrangementsmall cell transformationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENThoracic Cancer, Vol 12, Iss 22, Pp 3068-3071 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adenocarcinoma ROS1 rearrangement small cell transformation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	adenocarcinoma ROS1 rearrangement small cell transformation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Chi‐Hao Wu Po‐Lan Su Che‐Wei Hsu Chang‐Yao Chu Chien‐Chung Lin Small cell transformation in crizotinib‐resistant ROS1‐rearranged non‐small cell lung cancer with retention of ROS1 fusion: A case report
description	Abstract C‐ros oncogene 1 receptor tyrosine kinase (ROS1) rearrangement has been detected in patients with advanced non‐small cell lung cancer (NSCLC). Although ROS1 tyrosine kinase inhibitors (TKIs) provide a survival benefit for patients with ROS1‐rearranged advanced NSCLC, subsequent therapy remains limited. Small cell transformation is an important mechanism of drug resistance in epidermal growth factor receptor‐mutant NSCLC. However, its significance in mediating ROS1 resistance has not been determined yet. Here, we present the case of a 63‐year‐old man with ROS1‐rearranged advanced NSCLC who had disease progression with small cell transformation of the mediastinal lymph node after 8 months of treatment with crizotinib. More importantly, fluorescence in situ hybridization of post‐progression tumor biopsy demonstrated retention of ROS1 rearrangement. Tissue biopsy remains indispensable for patients who acquire resistance to ROS1 TKIs.
format	article
author	Chi‐Hao Wu Po‐Lan Su Che‐Wei Hsu Chang‐Yao Chu Chien‐Chung Lin
author_facet	Chi‐Hao Wu Po‐Lan Su Che‐Wei Hsu Chang‐Yao Chu Chien‐Chung Lin
author_sort	Chi‐Hao Wu
title	Small cell transformation in crizotinib‐resistant ROS1‐rearranged non‐small cell lung cancer with retention of ROS1 fusion: A case report
title_short	Small cell transformation in crizotinib‐resistant ROS1‐rearranged non‐small cell lung cancer with retention of ROS1 fusion: A case report
title_full	Small cell transformation in crizotinib‐resistant ROS1‐rearranged non‐small cell lung cancer with retention of ROS1 fusion: A case report
title_fullStr	Small cell transformation in crizotinib‐resistant ROS1‐rearranged non‐small cell lung cancer with retention of ROS1 fusion: A case report
title_full_unstemmed	Small cell transformation in crizotinib‐resistant ROS1‐rearranged non‐small cell lung cancer with retention of ROS1 fusion: A case report
title_sort	small cell transformation in crizotinib‐resistant ros1‐rearranged non‐small cell lung cancer with retention of ros1 fusion: a case report
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/ed32ab372512427db583dba7cab3a7cf
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Small cell transformation in crizotinib‐resistant ROS1‐rearranged non‐small cell lung cancer with retention of ROS1 fusion: A case report

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