Plasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations

Plasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations

Plasma biomarkers of amyloid, tau and neurodegeneration (ATN) need to be characterized in cognitively unimpaired (CU) elderly individuals. Here, the authors show plasma ATN biomarkers predict clinical deterioration and cognitive decline and show in a simulated clinical trial combining all three biom...

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Autores principales: Nicholas C. Cullen, Antoine Leuzy, Shorena Janelidze, Sebastian Palmqvist, Anna L. Svenningsson, Erik Stomrud, Jeffrey L. Dage, Niklas Mattsson-Carlgren, Oskar Hansson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ed33539191794e8abd8ebdc03d75b61a
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spelling oai:doaj.org-article:ed33539191794e8abd8ebdc03d75b61a2021-12-02T17:30:38ZPlasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations10.1038/s41467-021-23746-02041-1723https://doaj.org/article/ed33539191794e8abd8ebdc03d75b61a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23746-0https://doaj.org/toc/2041-1723Plasma biomarkers of amyloid, tau and neurodegeneration (ATN) need to be characterized in cognitively unimpaired (CU) elderly individuals. Here, the authors show plasma ATN biomarkers predict clinical deterioration and cognitive decline and show in a simulated clinical trial combining all three biomarkers reduced the required sample size.Nicholas C. CullenAntoine LeuzyShorena JanelidzeSebastian PalmqvistAnna L. SvenningssonErik StomrudJeffrey L. DageNiklas Mattsson-CarlgrenOskar HanssonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nicholas C. Cullen
Antoine Leuzy
Shorena Janelidze
Sebastian Palmqvist
Anna L. Svenningsson
Erik Stomrud
Jeffrey L. Dage
Niklas Mattsson-Carlgren
Oskar Hansson
Plasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations
description Plasma biomarkers of amyloid, tau and neurodegeneration (ATN) need to be characterized in cognitively unimpaired (CU) elderly individuals. Here, the authors show plasma ATN biomarkers predict clinical deterioration and cognitive decline and show in a simulated clinical trial combining all three biomarkers reduced the required sample size.
format article
author Nicholas C. Cullen
Antoine Leuzy
Shorena Janelidze
Sebastian Palmqvist
Anna L. Svenningsson
Erik Stomrud
Jeffrey L. Dage
Niklas Mattsson-Carlgren
Oskar Hansson
author_facet Nicholas C. Cullen
Antoine Leuzy
Shorena Janelidze
Sebastian Palmqvist
Anna L. Svenningsson
Erik Stomrud
Jeffrey L. Dage
Niklas Mattsson-Carlgren
Oskar Hansson
author_sort Nicholas C. Cullen
title Plasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations
title_short Plasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations
title_full Plasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations
title_fullStr Plasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations
title_full_unstemmed Plasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations
title_sort plasma biomarkers of alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ed33539191794e8abd8ebdc03d75b61a
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