The effect of smoking on the symptoms and progression of multiple sclerosis: a review

Afsaneh Shirani1, Helen Tremlett1,21Faculty of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada; 2Brain Research Centre, University of British Columbia, Vancouver, CanadaAbstract: Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disorder of the ce...

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Autores principales:	Afsaneh Shirani, Helen Tremlett
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ed380c1751944b189f30e60948d6e70d
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spelling	oai:doaj.org-article:ed380c1751944b189f30e60948d6e70d2021-12-02T04:23:21ZThe effect of smoking on the symptoms and progression of multiple sclerosis: a review1178-7031https://doaj.org/article/ed380c1751944b189f30e60948d6e70d2010-09-01T00:00:00Zhttp://www.dovepress.com/the-effect-of-smoking-on-the-symptoms-and-progression-of-multiple-scle-a5191https://doaj.org/toc/1178-7031Afsaneh Shirani1, Helen Tremlett1,21Faculty of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada; 2Brain Research Centre, University of British Columbia, Vancouver, CanadaAbstract: Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disorder of the central nervous system with characteristic demyelinating lesions and axonal loss. MS accounts for the most common cause of neurological disability in young adults in the Western world. The clinical manifestations and the course of MS are highly variable. The early stage of the disease is usually characterized by attacks of neurological dysfunction with complete or incomplete recovery, however, with time disability accumulates in many patients. MS is believed to result from an interplay between susceptibility genes and environmental factors, one of which is smoking. Smoking, a worldwide epidemic, can be regarded as an important risk factor for MS particularly because of its modifiable nature in the quest to prevent or temper the disease course in MS as well as providing possible insights into MS pathogenesis. There are also reports that smoking may influence the symptoms and disease progression in patients with MS. The purpose of this article is to review the effects of smoking on MS symptoms and progression. We conclude that (1) although there are some early reports on worsening of MS symptoms by smoking, the existing evidence is insufficient to thoroughly assess the effects of smoking on the myriad of MS symptoms and (2) smoking seems to adversely influence disease progression in MS patients. We also discuss the potential biological mechanisms linking smoking and MS.Keywords: smoking, multiple sclerosis, disease progression, symptoms Afsaneh ShiraniHelen TremlettDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2010, Iss default, Pp 115-126 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Afsaneh Shirani Helen Tremlett The effect of smoking on the symptoms and progression of multiple sclerosis: a review
description	Afsaneh Shirani1, Helen Tremlett1,21Faculty of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada; 2Brain Research Centre, University of British Columbia, Vancouver, CanadaAbstract: Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disorder of the central nervous system with characteristic demyelinating lesions and axonal loss. MS accounts for the most common cause of neurological disability in young adults in the Western world. The clinical manifestations and the course of MS are highly variable. The early stage of the disease is usually characterized by attacks of neurological dysfunction with complete or incomplete recovery, however, with time disability accumulates in many patients. MS is believed to result from an interplay between susceptibility genes and environmental factors, one of which is smoking. Smoking, a worldwide epidemic, can be regarded as an important risk factor for MS particularly because of its modifiable nature in the quest to prevent or temper the disease course in MS as well as providing possible insights into MS pathogenesis. There are also reports that smoking may influence the symptoms and disease progression in patients with MS. The purpose of this article is to review the effects of smoking on MS symptoms and progression. We conclude that (1) although there are some early reports on worsening of MS symptoms by smoking, the existing evidence is insufficient to thoroughly assess the effects of smoking on the myriad of MS symptoms and (2) smoking seems to adversely influence disease progression in MS patients. We also discuss the potential biological mechanisms linking smoking and MS.Keywords: smoking, multiple sclerosis, disease progression, symptoms
format	article
author	Afsaneh Shirani Helen Tremlett
author_facet	Afsaneh Shirani Helen Tremlett
author_sort	Afsaneh Shirani
title	The effect of smoking on the symptoms and progression of multiple sclerosis: a review
title_short	The effect of smoking on the symptoms and progression of multiple sclerosis: a review
title_full	The effect of smoking on the symptoms and progression of multiple sclerosis: a review
title_fullStr	The effect of smoking on the symptoms and progression of multiple sclerosis: a review
title_full_unstemmed	The effect of smoking on the symptoms and progression of multiple sclerosis: a review
title_sort	effect of smoking on the symptoms and progression of multiple sclerosis: a review
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/ed380c1751944b189f30e60948d6e70d
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The effect of smoking on the symptoms and progression of multiple sclerosis: a review

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