DNA methylation evidence against the accelerated aging hypothesis of schizophrenia

Abstract The accelerated aging hypothesis of schizophrenia posits that physiological changes throughout the body that are associated with normal aging occur at an earlier age in individuals with schizophrenia. Testing this hypothesis has been limited by problems measuring biological age. Recently, a...

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Autores principales:	Brandon C. McKinney, Huang Lin, Ying Ding, David A. Lewis, Robert A. Sweet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/ed396e9f81fe4ef7a7fac2ba0ce6e291
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spelling	oai:doaj.org-article:ed396e9f81fe4ef7a7fac2ba0ce6e2912021-12-02T15:18:49ZDNA methylation evidence against the accelerated aging hypothesis of schizophrenia10.1038/s41537-017-0017-52334-265Xhttps://doaj.org/article/ed396e9f81fe4ef7a7fac2ba0ce6e2912017-03-01T00:00:00Zhttps://doi.org/10.1038/s41537-017-0017-5https://doaj.org/toc/2334-265XAbstract The accelerated aging hypothesis of schizophrenia posits that physiological changes throughout the body that are associated with normal aging occur at an earlier age in individuals with schizophrenia. Testing this hypothesis has been limited by problems measuring biological age. Recently, a method using DNA methylation levels at 353 genomic sites to produce “DNA methylation age”, an estimate of tissue biological age, was described and validated. We used this method to test the hypothesis in the postmortem superior temporal gyrus of 22 non-psychiatric control and 22 schizophrenia subjects. DNA methylation age correlated with chronological age in both non-psychiatric control (r = 0.95, p < 0.0001) and schizophrenia subjects (r = 0.96, p < 0.0001). Age acceleration did not differ between non-psychiatric control and schizophrenia subjects (t = 1.27, p = 0.21). Our findings suggest there is no acceleration of brain aging in schizophrenia. Larger studies using samples from multiple brain regions and homogenous cell populations will be necessary to confirm these findings.Brandon C. McKinneyHuang LinYing DingDavid A. LewisRobert A. SweetNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 3, Iss 1, Pp 1-3 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Brandon C. McKinney Huang Lin Ying Ding David A. Lewis Robert A. Sweet DNA methylation evidence against the accelerated aging hypothesis of schizophrenia
description	Abstract The accelerated aging hypothesis of schizophrenia posits that physiological changes throughout the body that are associated with normal aging occur at an earlier age in individuals with schizophrenia. Testing this hypothesis has been limited by problems measuring biological age. Recently, a method using DNA methylation levels at 353 genomic sites to produce “DNA methylation age”, an estimate of tissue biological age, was described and validated. We used this method to test the hypothesis in the postmortem superior temporal gyrus of 22 non-psychiatric control and 22 schizophrenia subjects. DNA methylation age correlated with chronological age in both non-psychiatric control (r = 0.95, p < 0.0001) and schizophrenia subjects (r = 0.96, p < 0.0001). Age acceleration did not differ between non-psychiatric control and schizophrenia subjects (t = 1.27, p = 0.21). Our findings suggest there is no acceleration of brain aging in schizophrenia. Larger studies using samples from multiple brain regions and homogenous cell populations will be necessary to confirm these findings.
format	article
author	Brandon C. McKinney Huang Lin Ying Ding David A. Lewis Robert A. Sweet
author_facet	Brandon C. McKinney Huang Lin Ying Ding David A. Lewis Robert A. Sweet
author_sort	Brandon C. McKinney
title	DNA methylation evidence against the accelerated aging hypothesis of schizophrenia
title_short	DNA methylation evidence against the accelerated aging hypothesis of schizophrenia
title_full	DNA methylation evidence against the accelerated aging hypothesis of schizophrenia
title_fullStr	DNA methylation evidence against the accelerated aging hypothesis of schizophrenia
title_full_unstemmed	DNA methylation evidence against the accelerated aging hypothesis of schizophrenia
title_sort	dna methylation evidence against the accelerated aging hypothesis of schizophrenia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ed396e9f81fe4ef7a7fac2ba0ce6e291
work_keys_str_mv	AT brandoncmckinney dnamethylationevidenceagainsttheacceleratedaginghypothesisofschizophrenia AT huanglin dnamethylationevidenceagainsttheacceleratedaginghypothesisofschizophrenia AT yingding dnamethylationevidenceagainsttheacceleratedaginghypothesisofschizophrenia AT davidalewis dnamethylationevidenceagainsttheacceleratedaginghypothesisofschizophrenia AT robertasweet dnamethylationevidenceagainsttheacceleratedaginghypothesisofschizophrenia
_version_	1718387482728333312

DNA methylation evidence against the accelerated aging hypothesis of schizophrenia

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