Classification of patients with Alzheimer’s disease using the arterial pulse spectrum and a multilayer-perceptron analysis

Abstract Cerebrovascular atherosclerosis has been identified as a prominent pathological feature of Alzheimer’s disease (AD); the link between vessel pathology and AD risk may also extend to extracranial arteries. This study aimed to determine the effectiveness of using arterial pulse-wave measureme...

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Autores principales:	Shun-Ku Lin, Hsin Hsiu, Hsi-Sheng Chen, Chang-Jen Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed3a21a5f6c244bb876911ce7b29c619
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spelling	oai:doaj.org-article:ed3a21a5f6c244bb876911ce7b29c6192021-12-02T13:41:22ZClassification of patients with Alzheimer’s disease using the arterial pulse spectrum and a multilayer-perceptron analysis10.1038/s41598-021-87903-72045-2322https://doaj.org/article/ed3a21a5f6c244bb876911ce7b29c6192021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87903-7https://doaj.org/toc/2045-2322Abstract Cerebrovascular atherosclerosis has been identified as a prominent pathological feature of Alzheimer’s disease (AD); the link between vessel pathology and AD risk may also extend to extracranial arteries. This study aimed to determine the effectiveness of using arterial pulse-wave measurements and multilayer perceptron (MLP) analysis in distinguishing between AD and control subjects. Radial blood pressure waveform (BPW) and finger photoplethysmography signals were measured noninvasively for 3 min in 87 AD patients and 74 control subjects. The 5-layer MLP algorithm employed evaluated the following 40 harmonic pulse indices: amplitude proportion and its coefficient of variation, and phase angle and its standard deviation. The BPW indices differed significantly between the AD patients (6247 pulses) and control subjects (6626 pulses). Significant intergroup differences were found between mild, moderate, and severe AD (defined by Mini-Mental-State-Examination scores). The hold-out test results indicated an accuracy of 82.86%, a specificity of 92.31%, and a 0.83 AUC of ROC curve when using the MLP-based classification between AD and Control. The identified differences can be partly attributed to AD-induced changes in vascular elastic properties. The present findings may be meaningful in facilitating the development of a noninvasive, rapid, inexpensive, and objective method for detecting and monitoring the AD status.Shun-Ku LinHsin HsiuHsi-Sheng ChenChang-Jen YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shun-Ku Lin Hsin Hsiu Hsi-Sheng Chen Chang-Jen Yang Classification of patients with Alzheimer’s disease using the arterial pulse spectrum and a multilayer-perceptron analysis
description	Abstract Cerebrovascular atherosclerosis has been identified as a prominent pathological feature of Alzheimer’s disease (AD); the link between vessel pathology and AD risk may also extend to extracranial arteries. This study aimed to determine the effectiveness of using arterial pulse-wave measurements and multilayer perceptron (MLP) analysis in distinguishing between AD and control subjects. Radial blood pressure waveform (BPW) and finger photoplethysmography signals were measured noninvasively for 3 min in 87 AD patients and 74 control subjects. The 5-layer MLP algorithm employed evaluated the following 40 harmonic pulse indices: amplitude proportion and its coefficient of variation, and phase angle and its standard deviation. The BPW indices differed significantly between the AD patients (6247 pulses) and control subjects (6626 pulses). Significant intergroup differences were found between mild, moderate, and severe AD (defined by Mini-Mental-State-Examination scores). The hold-out test results indicated an accuracy of 82.86%, a specificity of 92.31%, and a 0.83 AUC of ROC curve when using the MLP-based classification between AD and Control. The identified differences can be partly attributed to AD-induced changes in vascular elastic properties. The present findings may be meaningful in facilitating the development of a noninvasive, rapid, inexpensive, and objective method for detecting and monitoring the AD status.
format	article
author	Shun-Ku Lin Hsin Hsiu Hsi-Sheng Chen Chang-Jen Yang
author_facet	Shun-Ku Lin Hsin Hsiu Hsi-Sheng Chen Chang-Jen Yang
author_sort	Shun-Ku Lin
title	Classification of patients with Alzheimer’s disease using the arterial pulse spectrum and a multilayer-perceptron analysis
title_short	Classification of patients with Alzheimer’s disease using the arterial pulse spectrum and a multilayer-perceptron analysis
title_full	Classification of patients with Alzheimer’s disease using the arterial pulse spectrum and a multilayer-perceptron analysis
title_fullStr	Classification of patients with Alzheimer’s disease using the arterial pulse spectrum and a multilayer-perceptron analysis
title_full_unstemmed	Classification of patients with Alzheimer’s disease using the arterial pulse spectrum and a multilayer-perceptron analysis
title_sort	classification of patients with alzheimer’s disease using the arterial pulse spectrum and a multilayer-perceptron analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed3a21a5f6c244bb876911ce7b29c619
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Classification of patients with Alzheimer’s disease using the arterial pulse spectrum and a multilayer-perceptron analysis

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