Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

Trypanosoma cruzi infection causes Chagas disease, but mechanisms underlying pathogenesis are unclear. Here, Silva et al. show that canonical PI3Kγ signaling in myeloid cells restricts T. cruzi infection in mice and that high PIK3CG expression correlates with low parasite levels in human Chagas’ hea...

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Main Authors:	Maria C. Silva, Marcela Davoli-Ferreira, Tiago S. Medina, Renata Sesti-Costa, Grace K. Silva, Carla D. Lopes, Lucas E. Cardozo, Fábio N. Gava, Konstantina Lyroni, Fabrício C. Dias, Amanda F. Frade, Monique Baron, Helder I. Nakaya, Florêncio Figueiredo, José C. Alves-Filho, Fernando Q. Cunha, Christos Tsatsanis, Christophe Chevillard, Edecio Cunha-Neto, Emilio Hirsch, João S. Silva, Thiago M. Cunha
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/ed3bd260c7f349aaacab38a75bacfe6c
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spelling	oai:doaj.org-article:ed3bd260c7f349aaacab38a75bacfe6c2021-12-02T14:39:07ZCanonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis10.1038/s41467-018-03986-32041-1723https://doaj.org/article/ed3bd260c7f349aaacab38a75bacfe6c2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03986-3https://doaj.org/toc/2041-1723Trypanosoma cruzi infection causes Chagas disease, but mechanisms underlying pathogenesis are unclear. Here, Silva et al. show that canonical PI3Kγ signaling in myeloid cells restricts T. cruzi infection in mice and that high PIK3CG expression correlates with low parasite levels in human Chagas’ hearts.Maria C. SilvaMarcela Davoli-FerreiraTiago S. MedinaRenata Sesti-CostaGrace K. SilvaCarla D. LopesLucas E. CardozoFábio N. GavaKonstantina LyroniFabrício C. DiasAmanda F. FradeMonique BaronHelder I. NakayaFlorêncio FigueiredoJosé C. Alves-FilhoFernando Q. CunhaChristos TsatsanisChristophe ChevillardEdecio Cunha-NetoEmilio HirschJoão S. SilvaThiago M. CunhaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria C. Silva Marcela Davoli-Ferreira Tiago S. Medina Renata Sesti-Costa Grace K. Silva Carla D. Lopes Lucas E. Cardozo Fábio N. Gava Konstantina Lyroni Fabrício C. Dias Amanda F. Frade Monique Baron Helder I. Nakaya Florêncio Figueiredo José C. Alves-Filho Fernando Q. Cunha Christos Tsatsanis Christophe Chevillard Edecio Cunha-Neto Emilio Hirsch João S. Silva Thiago M. Cunha Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis
description	Trypanosoma cruzi infection causes Chagas disease, but mechanisms underlying pathogenesis are unclear. Here, Silva et al. show that canonical PI3Kγ signaling in myeloid cells restricts T. cruzi infection in mice and that high PIK3CG expression correlates with low parasite levels in human Chagas’ hearts.
format	article
author	Maria C. Silva Marcela Davoli-Ferreira Tiago S. Medina Renata Sesti-Costa Grace K. Silva Carla D. Lopes Lucas E. Cardozo Fábio N. Gava Konstantina Lyroni Fabrício C. Dias Amanda F. Frade Monique Baron Helder I. Nakaya Florêncio Figueiredo José C. Alves-Filho Fernando Q. Cunha Christos Tsatsanis Christophe Chevillard Edecio Cunha-Neto Emilio Hirsch João S. Silva Thiago M. Cunha
author_facet	Maria C. Silva Marcela Davoli-Ferreira Tiago S. Medina Renata Sesti-Costa Grace K. Silva Carla D. Lopes Lucas E. Cardozo Fábio N. Gava Konstantina Lyroni Fabrício C. Dias Amanda F. Frade Monique Baron Helder I. Nakaya Florêncio Figueiredo José C. Alves-Filho Fernando Q. Cunha Christos Tsatsanis Christophe Chevillard Edecio Cunha-Neto Emilio Hirsch João S. Silva Thiago M. Cunha
author_sort	Maria C. Silva
title	Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis
title_short	Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis
title_full	Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis
title_fullStr	Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis
title_full_unstemmed	Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis
title_sort	canonical pi3kγ signaling in myeloid cells restricts trypanosoma cruzi infection and dampens chagasic myocarditis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ed3bd260c7f349aaacab38a75bacfe6c
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Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

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