Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

Trypanosoma cruzi infection causes Chagas disease, but mechanisms underlying pathogenesis are unclear. Here, Silva et al. show that canonical PI3Kγ signaling in myeloid cells restricts T. cruzi infection in mice and that high PIK3CG expression correlates with low parasite levels in human Chagas’ hea...

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Autores principales: Maria C. Silva, Marcela Davoli-Ferreira, Tiago S. Medina, Renata Sesti-Costa, Grace K. Silva, Carla D. Lopes, Lucas E. Cardozo, Fábio N. Gava, Konstantina Lyroni, Fabrício C. Dias, Amanda F. Frade, Monique Baron, Helder I. Nakaya, Florêncio Figueiredo, José C. Alves-Filho, Fernando Q. Cunha, Christos Tsatsanis, Christophe Chevillard, Edecio Cunha-Neto, Emilio Hirsch, João S. Silva, Thiago M. Cunha
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/ed3bd260c7f349aaacab38a75bacfe6c
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spelling oai:doaj.org-article:ed3bd260c7f349aaacab38a75bacfe6c2021-12-02T14:39:07ZCanonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis10.1038/s41467-018-03986-32041-1723https://doaj.org/article/ed3bd260c7f349aaacab38a75bacfe6c2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03986-3https://doaj.org/toc/2041-1723Trypanosoma cruzi infection causes Chagas disease, but mechanisms underlying pathogenesis are unclear. Here, Silva et al. show that canonical PI3Kγ signaling in myeloid cells restricts T. cruzi infection in mice and that high PIK3CG expression correlates with low parasite levels in human Chagas’ hearts.Maria C. SilvaMarcela Davoli-FerreiraTiago S. MedinaRenata Sesti-CostaGrace K. SilvaCarla D. LopesLucas E. CardozoFábio N. GavaKonstantina LyroniFabrício C. DiasAmanda F. FradeMonique BaronHelder I. NakayaFlorêncio FigueiredoJosé C. Alves-FilhoFernando Q. CunhaChristos TsatsanisChristophe ChevillardEdecio Cunha-NetoEmilio HirschJoão S. SilvaThiago M. CunhaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Maria C. Silva
Marcela Davoli-Ferreira
Tiago S. Medina
Renata Sesti-Costa
Grace K. Silva
Carla D. Lopes
Lucas E. Cardozo
Fábio N. Gava
Konstantina Lyroni
Fabrício C. Dias
Amanda F. Frade
Monique Baron
Helder I. Nakaya
Florêncio Figueiredo
José C. Alves-Filho
Fernando Q. Cunha
Christos Tsatsanis
Christophe Chevillard
Edecio Cunha-Neto
Emilio Hirsch
João S. Silva
Thiago M. Cunha
Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis
description Trypanosoma cruzi infection causes Chagas disease, but mechanisms underlying pathogenesis are unclear. Here, Silva et al. show that canonical PI3Kγ signaling in myeloid cells restricts T. cruzi infection in mice and that high PIK3CG expression correlates with low parasite levels in human Chagas’ hearts.
format article
author Maria C. Silva
Marcela Davoli-Ferreira
Tiago S. Medina
Renata Sesti-Costa
Grace K. Silva
Carla D. Lopes
Lucas E. Cardozo
Fábio N. Gava
Konstantina Lyroni
Fabrício C. Dias
Amanda F. Frade
Monique Baron
Helder I. Nakaya
Florêncio Figueiredo
José C. Alves-Filho
Fernando Q. Cunha
Christos Tsatsanis
Christophe Chevillard
Edecio Cunha-Neto
Emilio Hirsch
João S. Silva
Thiago M. Cunha
author_facet Maria C. Silva
Marcela Davoli-Ferreira
Tiago S. Medina
Renata Sesti-Costa
Grace K. Silva
Carla D. Lopes
Lucas E. Cardozo
Fábio N. Gava
Konstantina Lyroni
Fabrício C. Dias
Amanda F. Frade
Monique Baron
Helder I. Nakaya
Florêncio Figueiredo
José C. Alves-Filho
Fernando Q. Cunha
Christos Tsatsanis
Christophe Chevillard
Edecio Cunha-Neto
Emilio Hirsch
João S. Silva
Thiago M. Cunha
author_sort Maria C. Silva
title Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis
title_short Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis
title_full Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis
title_fullStr Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis
title_full_unstemmed Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis
title_sort canonical pi3kγ signaling in myeloid cells restricts trypanosoma cruzi infection and dampens chagasic myocarditis
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/ed3bd260c7f349aaacab38a75bacfe6c
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