A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population

Narumi Muto, 1,* Kentaro Oniki, 1,* Miku Kudo, 1 Yui Obata, 1 Yuki Sakamoto, 1 Naoto Tokumaru, 1 Tomoko Izuka, 1 Takehisa Watanabe, 2 Koji Otake, 3 Yasuhiro Ogata, 3 Junji Saruwatari 1 1Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumam...

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Autores principales:	Muto N, Oniki K, Kudo M, Obata Y, Sakamoto Y, Tokumaru N, Izuka T, Watanabe T, Otake K, Ogata Y, Saruwatari J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	weight status liver steatosis patatin-like phospholipase domain containing protein 3 genetic polymorphism Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/ed3d22588c3d461da248fab810327511
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spelling	oai:doaj.org-article:ed3d22588c3d461da248fab8103275112021-12-02T08:38:38ZA Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population1178-7007https://doaj.org/article/ed3d22588c3d461da248fab8103275112020-02-01T00:00:00Zhttps://www.dovepress.com/a-pilot-study-assessing-the-possible-combined-effect-of-physical-activ-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Narumi Muto, 1,* Kentaro Oniki, 1,* Miku Kudo, 1 Yui Obata, 1 Yuki Sakamoto, 1 Naoto Tokumaru, 1 Tomoko Izuka, 1 Takehisa Watanabe, 2 Koji Otake, 3 Yasuhiro Ogata, 3 Junji Saruwatari 1 1Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan; 2Departments of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan; 3Japanese Red Cross Kumamoto Health Care Center, Kumamoto, JapanThese authors contributed equally to this workCorrespondence: Junji SaruwatariDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, JapanTel/Fax +81 96-371-4512Email junsaru@gpo.kumamoto-u.ac.jpPurpose: The patatin-like phospholipase domain containing protein 3 (PNPLA3) rs738409 polymorphism (c.444C>G) is the most well-known genetic risk factor for non-alcoholic fatty liver disease (NAFLD), but whether or not physical activity influences the association between the PNPLA3 genotype and risk of NAFLD is unclear.Patients and Methods: A retrospective longitudinal analysis was conducted among 352 Japanese subjects. Each type of physical activity was assigned a metabolic equivalent (MET), and the subjects were classified into sedentary, low or high groups using the “METST” (METs × hours per week) value of 5 or 21 as a threshold.Results: Among the PNPLA3 G/G genotype carriers, the high and low METST groups had a lower risk of NAFLD than the sedentary METST group (odds ratio [95% confidence interval]: 0.14 [0.02– 0.99] and 0.16 [0.03– 1.04], respectively). Furthermore, the PNPLA3 C/C or C/G genotype carriers showed no significant difference in the risk of NAFLD among the three METS*T groups.Conclusion: The PNPLA3 rs738409 genotype may be associated with the beneficial effects of physical activity on the risk of NAFLD among elderly Japanese individuals. Further comprehensive investigations are therefore needed to verify the preliminary results.Keywords: weight status, liver steatosis, patatin-like phospholipase domain containing protein 3, genetic polymorphismMuto NOniki KKudo MObata YSakamoto YTokumaru NIzuka TWatanabe TOtake KOgata YSaruwatari JDove Medical Pressarticleweight statusliver steatosispatatin-like phospholipase domain containing protein 3genetic polymorphismSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 333-341 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	weight status liver steatosis patatin-like phospholipase domain containing protein 3 genetic polymorphism Specialties of internal medicine RC581-951
spellingShingle	weight status liver steatosis patatin-like phospholipase domain containing protein 3 genetic polymorphism Specialties of internal medicine RC581-951 Muto N Oniki K Kudo M Obata Y Sakamoto Y Tokumaru N Izuka T Watanabe T Otake K Ogata Y Saruwatari J A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population
description	Narumi Muto, 1,* Kentaro Oniki, 1,* Miku Kudo, 1 Yui Obata, 1 Yuki Sakamoto, 1 Naoto Tokumaru, 1 Tomoko Izuka, 1 Takehisa Watanabe, 2 Koji Otake, 3 Yasuhiro Ogata, 3 Junji Saruwatari 1 1Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan; 2Departments of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan; 3Japanese Red Cross Kumamoto Health Care Center, Kumamoto, JapanThese authors contributed equally to this workCorrespondence: Junji SaruwatariDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, JapanTel/Fax +81 96-371-4512Email junsaru@gpo.kumamoto-u.ac.jpPurpose: The patatin-like phospholipase domain containing protein 3 (PNPLA3) rs738409 polymorphism (c.444C>G) is the most well-known genetic risk factor for non-alcoholic fatty liver disease (NAFLD), but whether or not physical activity influences the association between the PNPLA3 genotype and risk of NAFLD is unclear.Patients and Methods: A retrospective longitudinal analysis was conducted among 352 Japanese subjects. Each type of physical activity was assigned a metabolic equivalent (MET), and the subjects were classified into sedentary, low or high groups using the “METST” (METs × hours per week) value of 5 or 21 as a threshold.Results: Among the PNPLA3 G/G genotype carriers, the high and low METST groups had a lower risk of NAFLD than the sedentary METST group (odds ratio [95% confidence interval]: 0.14 [0.02– 0.99] and 0.16 [0.03– 1.04], respectively). Furthermore, the PNPLA3 C/C or C/G genotype carriers showed no significant difference in the risk of NAFLD among the three METS*T groups.Conclusion: The PNPLA3 rs738409 genotype may be associated with the beneficial effects of physical activity on the risk of NAFLD among elderly Japanese individuals. Further comprehensive investigations are therefore needed to verify the preliminary results.Keywords: weight status, liver steatosis, patatin-like phospholipase domain containing protein 3, genetic polymorphism
format	article
author	Muto N Oniki K Kudo M Obata Y Sakamoto Y Tokumaru N Izuka T Watanabe T Otake K Ogata Y Saruwatari J
author_facet	Muto N Oniki K Kudo M Obata Y Sakamoto Y Tokumaru N Izuka T Watanabe T Otake K Ogata Y Saruwatari J
author_sort	Muto N
title	A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population
title_short	A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population
title_full	A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population
title_fullStr	A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population
title_full_unstemmed	A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population
title_sort	pilot study assessing the possible combined effect of physical activity and pnpla3 rs738409 polymorphism on the risk for non-alcoholic fatty liver disease in the japanese elderly general population
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/ed3d22588c3d461da248fab810327511
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A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population

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