Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
Here, the authors show structural, biochemical, and functional insights into the discovery of epichaperome‐ directed chemical probes for use in central nervous system diseases. Probes emerging from this work have translated to human clinical studies in Alzheimer’s disease and cancer.
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Nature Portfolio
2021
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oai:doaj.org-article:ed3d8f0c921541cb8291f5f96c64889e2021-12-02T16:34:05ZChemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system10.1038/s41467-021-24821-22041-1723https://doaj.org/article/ed3d8f0c921541cb8291f5f96c64889e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24821-2https://doaj.org/toc/2041-1723Here, the authors show structural, biochemical, and functional insights into the discovery of epichaperome‐ directed chemical probes for use in central nervous system diseases. Probes emerging from this work have translated to human clinical studies in Alzheimer’s disease and cancer.Alexander BolaenderDanuta ZatorskaHuazhong HeSuhasini JoshiSahil SharmaChander S. DigwalHardik J. PatelWeilin SunBrandon S. ImberStefan O. OchianaMaulik R. PatelLiza ShresthaSmit. K. ShahShuo WangRashad KarimovHui TaoPallav D. PatelAnanda Rodilla MartinPengrong YanPalak PanchalJustina AlmodovarAdriana CorbenAndreas RimnerStephen D. GinsbergSerge LyashchenkoEva BurnaziAnson KuTeja KalidindiSang Gyu LeeMilan GrkovskiBradley J. BeattiePat ZanzonicoJason S. LewisSteve LarsonAnna RodinaNagavarakishore PillarsettyViviane TabarMark P. DunphyTony TaldoneFumiko ShimizuGabriela ChiosisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
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Science Q |
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Science Q Alexander Bolaender Danuta Zatorska Huazhong He Suhasini Joshi Sahil Sharma Chander S. Digwal Hardik J. Patel Weilin Sun Brandon S. Imber Stefan O. Ochiana Maulik R. Patel Liza Shrestha Smit. K. Shah Shuo Wang Rashad Karimov Hui Tao Pallav D. Patel Ananda Rodilla Martin Pengrong Yan Palak Panchal Justina Almodovar Adriana Corben Andreas Rimner Stephen D. Ginsberg Serge Lyashchenko Eva Burnazi Anson Ku Teja Kalidindi Sang Gyu Lee Milan Grkovski Bradley J. Beattie Pat Zanzonico Jason S. Lewis Steve Larson Anna Rodina Nagavarakishore Pillarsetty Viviane Tabar Mark P. Dunphy Tony Taldone Fumiko Shimizu Gabriela Chiosis Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system |
| description |
Here, the authors show structural, biochemical, and functional insights into the discovery of epichaperome‐ directed chemical probes for use in central nervous system diseases. Probes emerging from this work have translated to human clinical studies in Alzheimer’s disease and cancer. |
| format |
article |
| author |
Alexander Bolaender Danuta Zatorska Huazhong He Suhasini Joshi Sahil Sharma Chander S. Digwal Hardik J. Patel Weilin Sun Brandon S. Imber Stefan O. Ochiana Maulik R. Patel Liza Shrestha Smit. K. Shah Shuo Wang Rashad Karimov Hui Tao Pallav D. Patel Ananda Rodilla Martin Pengrong Yan Palak Panchal Justina Almodovar Adriana Corben Andreas Rimner Stephen D. Ginsberg Serge Lyashchenko Eva Burnazi Anson Ku Teja Kalidindi Sang Gyu Lee Milan Grkovski Bradley J. Beattie Pat Zanzonico Jason S. Lewis Steve Larson Anna Rodina Nagavarakishore Pillarsetty Viviane Tabar Mark P. Dunphy Tony Taldone Fumiko Shimizu Gabriela Chiosis |
| author_facet |
Alexander Bolaender Danuta Zatorska Huazhong He Suhasini Joshi Sahil Sharma Chander S. Digwal Hardik J. Patel Weilin Sun Brandon S. Imber Stefan O. Ochiana Maulik R. Patel Liza Shrestha Smit. K. Shah Shuo Wang Rashad Karimov Hui Tao Pallav D. Patel Ananda Rodilla Martin Pengrong Yan Palak Panchal Justina Almodovar Adriana Corben Andreas Rimner Stephen D. Ginsberg Serge Lyashchenko Eva Burnazi Anson Ku Teja Kalidindi Sang Gyu Lee Milan Grkovski Bradley J. Beattie Pat Zanzonico Jason S. Lewis Steve Larson Anna Rodina Nagavarakishore Pillarsetty Viviane Tabar Mark P. Dunphy Tony Taldone Fumiko Shimizu Gabriela Chiosis |
| author_sort |
Alexander Bolaender |
| title |
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system |
| title_short |
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system |
| title_full |
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system |
| title_fullStr |
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system |
| title_full_unstemmed |
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system |
| title_sort |
chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ed3d8f0c921541cb8291f5f96c64889e |
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