Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes.

It is now widely accepted that at an early stage in the evolution of life an RNA world arose, in which RNAs both served as the genetic material and catalyzed diverse biochemical reactions. Then, proteins have gradually replaced RNAs because of their superior catalytic properties in catalysis over ti...

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Autores principales:	Liang Shen, Hong-Fang Ji
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed3ea63154b340b886230db1cafb69a9
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spelling	oai:doaj.org-article:ed3ea63154b340b886230db1cafb69a92021-11-18T06:50:04ZSmall cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes.1932-620310.1371/journal.pone.0022494https://doaj.org/article/ed3ea63154b340b886230db1cafb69a92011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21789260/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203It is now widely accepted that at an early stage in the evolution of life an RNA world arose, in which RNAs both served as the genetic material and catalyzed diverse biochemical reactions. Then, proteins have gradually replaced RNAs because of their superior catalytic properties in catalysis over time. Therefore, it is important to investigate how primitive functional proteins emerged from RNA world, which can shed light on the evolutionary pathway of life from RNA world to the modern world. In this work, we proposed that the emergence of most primitive functional proteins are assisted by the early primitive nucleotide cofactors, while only a minority are induced directly by RNAs based on the analysis of RNA-protein complexes. Furthermore, the present findings have significant implication for exploring the composition of primitive RNA, i.e., adenine base as principal building blocks.Liang ShenHong-Fang JiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22494 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liang Shen Hong-Fang Ji Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes.
description	It is now widely accepted that at an early stage in the evolution of life an RNA world arose, in which RNAs both served as the genetic material and catalyzed diverse biochemical reactions. Then, proteins have gradually replaced RNAs because of their superior catalytic properties in catalysis over time. Therefore, it is important to investigate how primitive functional proteins emerged from RNA world, which can shed light on the evolutionary pathway of life from RNA world to the modern world. In this work, we proposed that the emergence of most primitive functional proteins are assisted by the early primitive nucleotide cofactors, while only a minority are induced directly by RNAs based on the analysis of RNA-protein complexes. Furthermore, the present findings have significant implication for exploring the composition of primitive RNA, i.e., adenine base as principal building blocks.
format	article
author	Liang Shen Hong-Fang Ji
author_facet	Liang Shen Hong-Fang Ji
author_sort	Liang Shen
title	Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes.
title_short	Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes.
title_full	Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes.
title_fullStr	Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes.
title_full_unstemmed	Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes.
title_sort	small cofactors may assist protein emergence from rna world: clues from rna-protein complexes.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/ed3ea63154b340b886230db1cafb69a9
work_keys_str_mv	AT liangshen smallcofactorsmayassistproteinemergencefromrnaworldcluesfromrnaproteincomplexes AT hongfangji smallcofactorsmayassistproteinemergencefromrnaworldcluesfromrnaproteincomplexes
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Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes.

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