Creation of a Novel Inflammation-Based Score for Operable Colorectal Cancer Patients

Qian Huang,1 Yinghao Cao,2 Shouyi Wang,1 Rui Zhu1 1Department of Pediatric, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Department of Colorectal Surgery and Gastroenterology, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and T...

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Autores principales:	Huang Q, Cao Y, Wang S, Zhu R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	colorectal cancer systemic inflammation prognosis crc-specific inflammatory index survival nomogram Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ed40ef09073746d9bb40563151b43a30
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spelling	oai:doaj.org-article:ed40ef09073746d9bb40563151b43a302021-12-02T11:09:32ZCreation of a Novel Inflammation-Based Score for Operable Colorectal Cancer Patients1178-7031https://doaj.org/article/ed40ef09073746d9bb40563151b43a302020-10-01T00:00:00Zhttps://www.dovepress.com/creation-of-a-novel-inflammation-based-score-for-operable-colorectal-c-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Qian Huang,1 Yinghao Cao,2 Shouyi Wang,1 Rui Zhu1 1Department of Pediatric, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Department of Colorectal Surgery and Gastroenterology, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Rui ZhuDepartment of Pediatric, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuhan 430071, People’s Republic of ChinaEmail zhurui1226@126.comAim: Systemic inflammation has been implicated in the progression of patients with colorectal cancer (CRC). We evaluated the prognostic ability of a comprehensive score based on several inflammatory indexes in operable CRC patients.Patients and Methods: Between July 2013 and September 2017, this study retrospectively identified 1279 CRC patients receiving radical surgery in Wuhan Union Hospital and randomly assigned them into training (N=921) and validation (N=358) sets. A novel score, the CRC-specific inflammatory index (CSII), was developed from a series of inflammatory indexes significantly associated with survival in patients with CRC. This novel score was then divided into three categories and compared to the well-known systematic inflammatory index (SII) and TNM stage. Finally, a survival nomogram was generated by combining the CSII and other informative clinical features.Results: The CSII-OS was calculated as 1.110×lg ALRI + 1.082×CAR + 0.792×PI, while CSII-DFS was 1.709×lg ALRI + 1.033×CAR based on multivariable Cox regression analysis. Patients with high CSII experienced a worse OS (HR=23.72, 95% CI, 11.30– 49.78, P < 0.001) and worse DFS (HR=15.62, 95% CI, 6.95– 35.08, P < 0.001) compared to those in CRC patients with low CSII. Moreover, ROC analyses showed that the CSII possessed excellent performance (AUC=0.859) in predicting OS and DFS. The AUC of the OS nomogram based on CSII, TNM stage, and chemotherapy was 0.897, while that of the DFS nomogram based on CSII, T stage, and TNM stage was 0.873. High-quality calibration curves in both OS and DFS nomograms were observed. Verification in the validation dataset showed results consistent with those in the training dataset.Conclusion: The CSII is a CRC-specific prognostic score based on the combination of available inflammatory indexes. High CSII is a strong predictor of worse survival outcomes. The CSII also exhibits better predictive performance compared to SII or TNM stage in operable CRC patients.Keywords: colorectal cancer, systemic inflammation, prognosis, CRC-specific inflammatory index, survival nomogramHuang QCao YWang SZhu RDove Medical Pressarticlecolorectal cancersystemic inflammationprognosiscrc-specific inflammatory indexsurvival nomogramPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 659-671 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer systemic inflammation prognosis crc-specific inflammatory index survival nomogram Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	colorectal cancer systemic inflammation prognosis crc-specific inflammatory index survival nomogram Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Huang Q Cao Y Wang S Zhu R Creation of a Novel Inflammation-Based Score for Operable Colorectal Cancer Patients
description	Qian Huang,1 Yinghao Cao,2 Shouyi Wang,1 Rui Zhu1 1Department of Pediatric, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Department of Colorectal Surgery and Gastroenterology, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Rui ZhuDepartment of Pediatric, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuhan 430071, People’s Republic of ChinaEmail zhurui1226@126.comAim: Systemic inflammation has been implicated in the progression of patients with colorectal cancer (CRC). We evaluated the prognostic ability of a comprehensive score based on several inflammatory indexes in operable CRC patients.Patients and Methods: Between July 2013 and September 2017, this study retrospectively identified 1279 CRC patients receiving radical surgery in Wuhan Union Hospital and randomly assigned them into training (N=921) and validation (N=358) sets. A novel score, the CRC-specific inflammatory index (CSII), was developed from a series of inflammatory indexes significantly associated with survival in patients with CRC. This novel score was then divided into three categories and compared to the well-known systematic inflammatory index (SII) and TNM stage. Finally, a survival nomogram was generated by combining the CSII and other informative clinical features.Results: The CSII-OS was calculated as 1.110×lg ALRI + 1.082×CAR + 0.792×PI, while CSII-DFS was 1.709×lg ALRI + 1.033×CAR based on multivariable Cox regression analysis. Patients with high CSII experienced a worse OS (HR=23.72, 95% CI, 11.30– 49.78, P < 0.001) and worse DFS (HR=15.62, 95% CI, 6.95– 35.08, P < 0.001) compared to those in CRC patients with low CSII. Moreover, ROC analyses showed that the CSII possessed excellent performance (AUC=0.859) in predicting OS and DFS. The AUC of the OS nomogram based on CSII, TNM stage, and chemotherapy was 0.897, while that of the DFS nomogram based on CSII, T stage, and TNM stage was 0.873. High-quality calibration curves in both OS and DFS nomograms were observed. Verification in the validation dataset showed results consistent with those in the training dataset.Conclusion: The CSII is a CRC-specific prognostic score based on the combination of available inflammatory indexes. High CSII is a strong predictor of worse survival outcomes. The CSII also exhibits better predictive performance compared to SII or TNM stage in operable CRC patients.Keywords: colorectal cancer, systemic inflammation, prognosis, CRC-specific inflammatory index, survival nomogram
format	article
author	Huang Q Cao Y Wang S Zhu R
author_facet	Huang Q Cao Y Wang S Zhu R
author_sort	Huang Q
title	Creation of a Novel Inflammation-Based Score for Operable Colorectal Cancer Patients
title_short	Creation of a Novel Inflammation-Based Score for Operable Colorectal Cancer Patients
title_full	Creation of a Novel Inflammation-Based Score for Operable Colorectal Cancer Patients
title_fullStr	Creation of a Novel Inflammation-Based Score for Operable Colorectal Cancer Patients
title_full_unstemmed	Creation of a Novel Inflammation-Based Score for Operable Colorectal Cancer Patients
title_sort	creation of a novel inflammation-based score for operable colorectal cancer patients
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/ed40ef09073746d9bb40563151b43a30
work_keys_str_mv	AT huangq creationofanovelinflammationbasedscoreforoperablecolorectalcancerpatients AT caoy creationofanovelinflammationbasedscoreforoperablecolorectalcancerpatients AT wangs creationofanovelinflammationbasedscoreforoperablecolorectalcancerpatients AT zhur creationofanovelinflammationbasedscoreforoperablecolorectalcancerpatients
_version_	1718396204944982016

Creation of a Novel Inflammation-Based Score for Operable Colorectal Cancer Patients

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