Cytotoxic aggregation and amyloid formation by the myostatin precursor protein.
Myostatin, a negative regulator of muscle growth, has been implicated in sporadic inclusion body myositis (sIBM). sIBM is the most common age-related muscle-wastage disease with a pathogenesis similar to that of amyloid disorders such as Alzheimer's and Parkinson's diseases. Myostatin prec...
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Main Authors: | Carlene S Starck, Andrew J Sutherland-Smith |
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Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2010
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Online Access: | https://doaj.org/article/ed445096ce704ad78357e39a095529c7 |
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