Evaluation of the prognostic value of CBXs in gastric cancer patients

Abstract Chromobox (CBX) proteins were suggested to exert epigenetic regulatory and transcriptionally repressing effects on target genes and might play key roles in the carcinogenesis of a variety of carcinomas. Nevertheless, the functions and prognostic significance of CBXs in gastric cancer (GC) r...

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Autores principales:	Mengya He, Limin Yue, Haiyan Wang, Feiyan Yu, Mingyang Yu, Peng Ni, Ke Zhang, Shuaiyin Chen, Guangcai Duan, Rongguang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed45b062617746aa8ae15c9c8f7a72bb
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spelling	oai:doaj.org-article:ed45b062617746aa8ae15c9c8f7a72bb2021-12-02T17:52:32ZEvaluation of the prognostic value of CBXs in gastric cancer patients10.1038/s41598-021-91649-72045-2322https://doaj.org/article/ed45b062617746aa8ae15c9c8f7a72bb2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91649-7https://doaj.org/toc/2045-2322Abstract Chromobox (CBX) proteins were suggested to exert epigenetic regulatory and transcriptionally repressing effects on target genes and might play key roles in the carcinogenesis of a variety of carcinomas. Nevertheless, the functions and prognostic significance of CBXs in gastric cancer (GC) remain unclear. The current study investigated the roles of CBXs in the prognosis of GC using the Oncomine, The Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, The Cancer Genome Atlas (TCGA), and cBioPortal databases. CBX1/2/3/4/5 were significantly upregulated in GC tissues compared with normal tissues, and CBX7 was downregulated. Multivariate analysis showed that high mRNA expression levels of CBX3/8 were independent prognostic factors for prolonged OS in GC patients. In addition, the genetic mutation rate of CBXs was 37% in GC patients, and genetic alterations in CBXs showed no association with OS or disease-free survival (DFS) in GC patients. These results indicated that CBX3/8 can be prognostic biomarkers for the survival of GC patients.Mengya HeLimin YueHaiyan WangFeiyan YuMingyang YuPeng NiKe ZhangShuaiyin ChenGuangcai DuanRongguang ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mengya He Limin Yue Haiyan Wang Feiyan Yu Mingyang Yu Peng Ni Ke Zhang Shuaiyin Chen Guangcai Duan Rongguang Zhang Evaluation of the prognostic value of CBXs in gastric cancer patients
description	Abstract Chromobox (CBX) proteins were suggested to exert epigenetic regulatory and transcriptionally repressing effects on target genes and might play key roles in the carcinogenesis of a variety of carcinomas. Nevertheless, the functions and prognostic significance of CBXs in gastric cancer (GC) remain unclear. The current study investigated the roles of CBXs in the prognosis of GC using the Oncomine, The Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, The Cancer Genome Atlas (TCGA), and cBioPortal databases. CBX1/2/3/4/5 were significantly upregulated in GC tissues compared with normal tissues, and CBX7 was downregulated. Multivariate analysis showed that high mRNA expression levels of CBX3/8 were independent prognostic factors for prolonged OS in GC patients. In addition, the genetic mutation rate of CBXs was 37% in GC patients, and genetic alterations in CBXs showed no association with OS or disease-free survival (DFS) in GC patients. These results indicated that CBX3/8 can be prognostic biomarkers for the survival of GC patients.
format	article
author	Mengya He Limin Yue Haiyan Wang Feiyan Yu Mingyang Yu Peng Ni Ke Zhang Shuaiyin Chen Guangcai Duan Rongguang Zhang
author_facet	Mengya He Limin Yue Haiyan Wang Feiyan Yu Mingyang Yu Peng Ni Ke Zhang Shuaiyin Chen Guangcai Duan Rongguang Zhang
author_sort	Mengya He
title	Evaluation of the prognostic value of CBXs in gastric cancer patients
title_short	Evaluation of the prognostic value of CBXs in gastric cancer patients
title_full	Evaluation of the prognostic value of CBXs in gastric cancer patients
title_fullStr	Evaluation of the prognostic value of CBXs in gastric cancer patients
title_full_unstemmed	Evaluation of the prognostic value of CBXs in gastric cancer patients
title_sort	evaluation of the prognostic value of cbxs in gastric cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed45b062617746aa8ae15c9c8f7a72bb
work_keys_str_mv	AT mengyahe evaluationoftheprognosticvalueofcbxsingastriccancerpatients AT liminyue evaluationoftheprognosticvalueofcbxsingastriccancerpatients AT haiyanwang evaluationoftheprognosticvalueofcbxsingastriccancerpatients AT feiyanyu evaluationoftheprognosticvalueofcbxsingastriccancerpatients AT mingyangyu evaluationoftheprognosticvalueofcbxsingastriccancerpatients AT pengni evaluationoftheprognosticvalueofcbxsingastriccancerpatients AT kezhang evaluationoftheprognosticvalueofcbxsingastriccancerpatients AT shuaiyinchen evaluationoftheprognosticvalueofcbxsingastriccancerpatients AT guangcaiduan evaluationoftheprognosticvalueofcbxsingastriccancerpatients AT rongguangzhang evaluationoftheprognosticvalueofcbxsingastriccancerpatients
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Evaluation of the prognostic value of CBXs in gastric cancer patients

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