Inflammatory markers and risk of cardiovascular mortality in relation to diabetes status in the HUNT study

Abstract Inflammatory markers have been associated with increased risk of cardiovascular mortality in general populations. We assessed whether these associations differ by diabetes status. From a population-based cohort study (n = 62,237) we included all participants with diabetes (n = 1753) and a c...

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Autores principales:	Lena Løfblad, Gunhild Garmo Hov, Arne Åsberg, Vibeke Videm
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed49d88caec9493d91a76f37b4ef5190
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spelling	oai:doaj.org-article:ed49d88caec9493d91a76f37b4ef51902021-12-02T16:35:46ZInflammatory markers and risk of cardiovascular mortality in relation to diabetes status in the HUNT study10.1038/s41598-021-94995-82045-2322https://doaj.org/article/ed49d88caec9493d91a76f37b4ef51902021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94995-8https://doaj.org/toc/2045-2322Abstract Inflammatory markers have been associated with increased risk of cardiovascular mortality in general populations. We assessed whether these associations differ by diabetes status. From a population-based cohort study (n = 62,237) we included all participants with diabetes (n = 1753) and a control group without diabetes (n = 1818). Cox regression models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CI) for possible associations with cardiovascular mortality of 4 different inflammatory markers; C-reactive protein (CRP), calprotectin, neopterin and lactoferrin. During a median follow-up of 13.9 years, 728 (20.4%) died from cardiovascular disease (CVD). After adjustment for age, sex and diabetes, the associations of all inflammatory markers with risk of cardiovascular mortality were log-linear (all P ≤ 0.017 for trend) and did not differ according to diabetes status (all P ≥ 0.53 for interaction). After further adjustments for established risk factors, only CRP remained independently associated with cardiovascular mortality. HRs were 1.22 (1.12–1.32) per standard deviation higher loge CRP concentration and 1.91 (1.50–2.43) when comparing individuals in the top versus bottom quartile. The associations of CRP, calprotectin, lactoferrin and neopterin with cardiovascular mortality did not differ by diabetes, suggesting that any potential prognostic value of these markers is independent of diabetes status.Lena LøfbladGunhild Garmo HovArne ÅsbergVibeke VidemNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lena Løfblad Gunhild Garmo Hov Arne Åsberg Vibeke Videm Inflammatory markers and risk of cardiovascular mortality in relation to diabetes status in the HUNT study
description	Abstract Inflammatory markers have been associated with increased risk of cardiovascular mortality in general populations. We assessed whether these associations differ by diabetes status. From a population-based cohort study (n = 62,237) we included all participants with diabetes (n = 1753) and a control group without diabetes (n = 1818). Cox regression models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CI) for possible associations with cardiovascular mortality of 4 different inflammatory markers; C-reactive protein (CRP), calprotectin, neopterin and lactoferrin. During a median follow-up of 13.9 years, 728 (20.4%) died from cardiovascular disease (CVD). After adjustment for age, sex and diabetes, the associations of all inflammatory markers with risk of cardiovascular mortality were log-linear (all P ≤ 0.017 for trend) and did not differ according to diabetes status (all P ≥ 0.53 for interaction). After further adjustments for established risk factors, only CRP remained independently associated with cardiovascular mortality. HRs were 1.22 (1.12–1.32) per standard deviation higher loge CRP concentration and 1.91 (1.50–2.43) when comparing individuals in the top versus bottom quartile. The associations of CRP, calprotectin, lactoferrin and neopterin with cardiovascular mortality did not differ by diabetes, suggesting that any potential prognostic value of these markers is independent of diabetes status.
format	article
author	Lena Løfblad Gunhild Garmo Hov Arne Åsberg Vibeke Videm
author_facet	Lena Løfblad Gunhild Garmo Hov Arne Åsberg Vibeke Videm
author_sort	Lena Løfblad
title	Inflammatory markers and risk of cardiovascular mortality in relation to diabetes status in the HUNT study
title_short	Inflammatory markers and risk of cardiovascular mortality in relation to diabetes status in the HUNT study
title_full	Inflammatory markers and risk of cardiovascular mortality in relation to diabetes status in the HUNT study
title_fullStr	Inflammatory markers and risk of cardiovascular mortality in relation to diabetes status in the HUNT study
title_full_unstemmed	Inflammatory markers and risk of cardiovascular mortality in relation to diabetes status in the HUNT study
title_sort	inflammatory markers and risk of cardiovascular mortality in relation to diabetes status in the hunt study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed49d88caec9493d91a76f37b4ef5190
work_keys_str_mv	AT lenaløfblad inflammatorymarkersandriskofcardiovascularmortalityinrelationtodiabetesstatusinthehuntstudy AT gunhildgarmohov inflammatorymarkersandriskofcardiovascularmortalityinrelationtodiabetesstatusinthehuntstudy AT arneasberg inflammatorymarkersandriskofcardiovascularmortalityinrelationtodiabetesstatusinthehuntstudy AT vibekevidem inflammatorymarkersandriskofcardiovascularmortalityinrelationtodiabetesstatusinthehuntstudy
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Inflammatory markers and risk of cardiovascular mortality in relation to diabetes status in the HUNT study

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