Quantification of contrast agent uptake in the hepatobiliary phase helps to differentiate hepatocellular carcinoma grade

Abstract This study aimed to assess the degree of differentiation of hepatocellular carcinoma (HCC) using Gd-EOB-DTPA-assisted magnetic resonance imaging (MRI) with T1 relaxometry. Thirty-three solitary HCC lesions were included in this retrospective study. This study's inclusion criteria were...

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Autores principales:	Michael Haimerl, Kirsten Utpatel, Andrea Götz, Florian Zeman, Claudia Fellner, Dominik Nickel, Lukas Luerken, Frank Brennfleck, Christian Stroszczynski, Alexander Scheiter, Niklas Verloh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed4ba9157f954786853599bd0b0a3e96
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spelling	oai:doaj.org-article:ed4ba9157f954786853599bd0b0a3e962021-11-28T12:21:11ZQuantification of contrast agent uptake in the hepatobiliary phase helps to differentiate hepatocellular carcinoma grade10.1038/s41598-021-02499-22045-2322https://doaj.org/article/ed4ba9157f954786853599bd0b0a3e962021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02499-2https://doaj.org/toc/2045-2322Abstract This study aimed to assess the degree of differentiation of hepatocellular carcinoma (HCC) using Gd-EOB-DTPA-assisted magnetic resonance imaging (MRI) with T1 relaxometry. Thirty-three solitary HCC lesions were included in this retrospective study. This study's inclusion criteria were preoperative Gd-EOB-DTPA-assisted MRI of the liver and a histopathological evaluation after hepatic tumor resection. T1 maps of the liver were evaluated to determine the T1 relaxation time and reduction rate between the native phase and hepatobiliary phase (HBP) in liver lesions. These findings were correlated with the histopathologically determined degree of HCC differentiation (G1, well-differentiated; G2, moderately differentiated; G3, poorly differentiated). There was no significant difference between well-differentiated (950.2 ± 140.2 ms) and moderately/poorly differentiated (1009.4 ± 202.0 ms) HCCs in the native T1 maps. After contrast medium administration, a significant difference (p ≤ 0.001) in the mean T1 relaxation time in the HBP was found between well-differentiated (555.4 ± 140.2 ms) and moderately/poorly differentiated (750.9 ± 146.4 ms) HCCs. For well-differentiated HCCs, the reduction rate in the T1 time was significantly higher at 0.40 ± 0.15 than for moderately/poorly differentiated HCCs (0.25 ± 0.07; p = 0.006). In conclusion this study suggests that the uptake of Gd-EOB-DTPA in HCCs is correlated with tumor grade. Thus, Gd-EOB-DTPA-assisted T1 relaxometry can help to further differentiation of HCC.Michael HaimerlKirsten UtpatelAndrea GötzFlorian ZemanClaudia FellnerDominik NickelLukas LuerkenFrank BrennfleckChristian StroszczynskiAlexander ScheiterNiklas VerlohNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael Haimerl Kirsten Utpatel Andrea Götz Florian Zeman Claudia Fellner Dominik Nickel Lukas Luerken Frank Brennfleck Christian Stroszczynski Alexander Scheiter Niklas Verloh Quantification of contrast agent uptake in the hepatobiliary phase helps to differentiate hepatocellular carcinoma grade
description	Abstract This study aimed to assess the degree of differentiation of hepatocellular carcinoma (HCC) using Gd-EOB-DTPA-assisted magnetic resonance imaging (MRI) with T1 relaxometry. Thirty-three solitary HCC lesions were included in this retrospective study. This study's inclusion criteria were preoperative Gd-EOB-DTPA-assisted MRI of the liver and a histopathological evaluation after hepatic tumor resection. T1 maps of the liver were evaluated to determine the T1 relaxation time and reduction rate between the native phase and hepatobiliary phase (HBP) in liver lesions. These findings were correlated with the histopathologically determined degree of HCC differentiation (G1, well-differentiated; G2, moderately differentiated; G3, poorly differentiated). There was no significant difference between well-differentiated (950.2 ± 140.2 ms) and moderately/poorly differentiated (1009.4 ± 202.0 ms) HCCs in the native T1 maps. After contrast medium administration, a significant difference (p ≤ 0.001) in the mean T1 relaxation time in the HBP was found between well-differentiated (555.4 ± 140.2 ms) and moderately/poorly differentiated (750.9 ± 146.4 ms) HCCs. For well-differentiated HCCs, the reduction rate in the T1 time was significantly higher at 0.40 ± 0.15 than for moderately/poorly differentiated HCCs (0.25 ± 0.07; p = 0.006). In conclusion this study suggests that the uptake of Gd-EOB-DTPA in HCCs is correlated with tumor grade. Thus, Gd-EOB-DTPA-assisted T1 relaxometry can help to further differentiation of HCC.
format	article
author	Michael Haimerl Kirsten Utpatel Andrea Götz Florian Zeman Claudia Fellner Dominik Nickel Lukas Luerken Frank Brennfleck Christian Stroszczynski Alexander Scheiter Niklas Verloh
author_facet	Michael Haimerl Kirsten Utpatel Andrea Götz Florian Zeman Claudia Fellner Dominik Nickel Lukas Luerken Frank Brennfleck Christian Stroszczynski Alexander Scheiter Niklas Verloh
author_sort	Michael Haimerl
title	Quantification of contrast agent uptake in the hepatobiliary phase helps to differentiate hepatocellular carcinoma grade
title_short	Quantification of contrast agent uptake in the hepatobiliary phase helps to differentiate hepatocellular carcinoma grade
title_full	Quantification of contrast agent uptake in the hepatobiliary phase helps to differentiate hepatocellular carcinoma grade
title_fullStr	Quantification of contrast agent uptake in the hepatobiliary phase helps to differentiate hepatocellular carcinoma grade
title_full_unstemmed	Quantification of contrast agent uptake in the hepatobiliary phase helps to differentiate hepatocellular carcinoma grade
title_sort	quantification of contrast agent uptake in the hepatobiliary phase helps to differentiate hepatocellular carcinoma grade
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed4ba9157f954786853599bd0b0a3e96
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Quantification of contrast agent uptake in the hepatobiliary phase helps to differentiate hepatocellular carcinoma grade

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