Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction

Premature infants are vulnerable to hypoxia and thus white matter injury, especially in the cerebellum, which develops during late gestation. Here, the authors test the effects of perinatal hypoxia on motor performance and rescue behavioral deficits using the GABA reuptake inhibitor Tiagabine.

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Autores principales:	Aaron Sathyanesan, Srikanya Kundu, Joseph Abbah, Vittorio Gallo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ed4e48c4a48a4dbca1a9160a13449bb0
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spelling	oai:doaj.org-article:ed4e48c4a48a4dbca1a9160a13449bb02021-12-02T14:39:45ZNeonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction10.1038/s41467-018-05656-w2041-1723https://doaj.org/article/ed4e48c4a48a4dbca1a9160a13449bb02018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05656-whttps://doaj.org/toc/2041-1723Premature infants are vulnerable to hypoxia and thus white matter injury, especially in the cerebellum, which develops during late gestation. Here, the authors test the effects of perinatal hypoxia on motor performance and rescue behavioral deficits using the GABA reuptake inhibitor Tiagabine.Aaron SathyanesanSrikanya KunduJoseph AbbahVittorio GalloNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aaron Sathyanesan Srikanya Kundu Joseph Abbah Vittorio Gallo Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction
description	Premature infants are vulnerable to hypoxia and thus white matter injury, especially in the cerebellum, which develops during late gestation. Here, the authors test the effects of perinatal hypoxia on motor performance and rescue behavioral deficits using the GABA reuptake inhibitor Tiagabine.
format	article
author	Aaron Sathyanesan Srikanya Kundu Joseph Abbah Vittorio Gallo
author_facet	Aaron Sathyanesan Srikanya Kundu Joseph Abbah Vittorio Gallo
author_sort	Aaron Sathyanesan
title	Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction
title_short	Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction
title_full	Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction
title_fullStr	Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction
title_full_unstemmed	Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction
title_sort	neonatal brain injury causes cerebellar learning deficits and purkinje cell dysfunction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ed4e48c4a48a4dbca1a9160a13449bb0
work_keys_str_mv	AT aaronsathyanesan neonatalbraininjurycausescerebellarlearningdeficitsandpurkinjecelldysfunction AT srikanyakundu neonatalbraininjurycausescerebellarlearningdeficitsandpurkinjecelldysfunction AT josephabbah neonatalbraininjurycausescerebellarlearningdeficitsandpurkinjecelldysfunction AT vittoriogallo neonatalbraininjurycausescerebellarlearningdeficitsandpurkinjecelldysfunction
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Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction

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