Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties

Abstract The present work was conducted to develop a new polysaccharide‐based encapsulation system via electrostatic interactions between Prunus armeniaca gum exudates (PAGE) and Ca2+ ions to enhance the biological activity and bioavailability of curcumin. The effects of different levels of pH (6, 7...

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Autores principales:	Davoud Salarbashi, Mohsen Tafaghodi, Morteza Fathi, Seyyed Mohammad aboutorabzade, Farzaneh Sabbagh
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	curcumin encapsulation nanoparticles Prunus armeniaca gum exudates release study Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/ed4ff60d9f45429ea6c984bde16c9f97
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spelling	oai:doaj.org-article:ed4ff60d9f45429ea6c984bde16c9f972021-11-04T13:06:43ZDevelopment of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties2048-717710.1002/fsn3.2562https://doaj.org/article/ed4ff60d9f45429ea6c984bde16c9f972021-11-01T00:00:00Zhttps://doi.org/10.1002/fsn3.2562https://doaj.org/toc/2048-7177Abstract The present work was conducted to develop a new polysaccharide‐based encapsulation system via electrostatic interactions between Prunus armeniaca gum exudates (PAGE) and Ca2+ ions to enhance the biological activity and bioavailability of curcumin. The effects of different levels of pH (6, 7, and 8) and ion concentrations (1, 3, and 5) on the particle diameter and surface charge of the samples were examined. The encapsulation efficiency in the PAGE‐based nanoparticles was realized to be 86.1%, indicating the encapsulation technique applied in this study was effective to entrap most of the curcumin within the PAGE matrix. The nanoparticles showed a smooth surface with spherical shape. Fourier transform infrared spectroscopy (FT‐IR) and X‐ray diffraction (X‐ray) studies confirmed the formation of polyelectrolyte complexation. The cumulative release of curcumin in simulated gastrointestinal tract was less than 75%, revealing a gradual release trend. Both pure curcumin and curcumin‐loaded nanoparticles were toxic to the cancer cell lines.Davoud SalarbashiMohsen TafaghodiMorteza FathiSeyyed Mohammad aboutorabzadeFarzaneh SabbaghWileyarticlecurcuminencapsulationnanoparticlesPrunus armeniaca gum exudatesrelease studyNutrition. Foods and food supplyTX341-641ENFood Science & Nutrition, Vol 9, Iss 11, Pp 6109-6119 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	curcumin encapsulation nanoparticles Prunus armeniaca gum exudates release study Nutrition. Foods and food supply TX341-641
spellingShingle	curcumin encapsulation nanoparticles Prunus armeniaca gum exudates release study Nutrition. Foods and food supply TX341-641 Davoud Salarbashi Mohsen Tafaghodi Morteza Fathi Seyyed Mohammad aboutorabzade Farzaneh Sabbagh Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties
description	Abstract The present work was conducted to develop a new polysaccharide‐based encapsulation system via electrostatic interactions between Prunus armeniaca gum exudates (PAGE) and Ca2+ ions to enhance the biological activity and bioavailability of curcumin. The effects of different levels of pH (6, 7, and 8) and ion concentrations (1, 3, and 5) on the particle diameter and surface charge of the samples were examined. The encapsulation efficiency in the PAGE‐based nanoparticles was realized to be 86.1%, indicating the encapsulation technique applied in this study was effective to entrap most of the curcumin within the PAGE matrix. The nanoparticles showed a smooth surface with spherical shape. Fourier transform infrared spectroscopy (FT‐IR) and X‐ray diffraction (X‐ray) studies confirmed the formation of polyelectrolyte complexation. The cumulative release of curcumin in simulated gastrointestinal tract was less than 75%, revealing a gradual release trend. Both pure curcumin and curcumin‐loaded nanoparticles were toxic to the cancer cell lines.
format	article
author	Davoud Salarbashi Mohsen Tafaghodi Morteza Fathi Seyyed Mohammad aboutorabzade Farzaneh Sabbagh
author_facet	Davoud Salarbashi Mohsen Tafaghodi Morteza Fathi Seyyed Mohammad aboutorabzade Farzaneh Sabbagh
author_sort	Davoud Salarbashi
title	Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties
title_short	Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties
title_full	Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties
title_fullStr	Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties
title_full_unstemmed	Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties
title_sort	development of curcumin‐loaded prunus armeniaca gum nanoparticles: synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/ed4ff60d9f45429ea6c984bde16c9f97
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Development of curcumin‐loaded Prunus armeniaca gum nanoparticles: Synthesis, characterization, control release behavior, and evaluation of anticancer and antimicrobial properties

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