CRISPR-Cas Technology: Emerging Applications in Clinical Microbiology and Infectious Diseases

Through the years, many promising tools for gene editing have been developed including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), CRISPR-associated protein 9 (Cas9), and homing endonucleases (HEs). These novel technologies are now leading new scientific a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sahar Serajian, Ehsan Ahmadpour, Sonia M. Rodrigues Oliveira, Maria de Lourdes Pereira, Siamak Heidarzadeh
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	CRISPR gene editing infectious diseases antimicrobial resistance parasitology Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/ed5081de19ea4c7fb466d5014f7e1f4f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ed5081de19ea4c7fb466d5014f7e1f4f
record_format	dspace
spelling	oai:doaj.org-article:ed5081de19ea4c7fb466d5014f7e1f4f2021-11-25T18:39:54ZCRISPR-Cas Technology: Emerging Applications in Clinical Microbiology and Infectious Diseases10.3390/ph141111711424-8247https://doaj.org/article/ed5081de19ea4c7fb466d5014f7e1f4f2021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1171https://doaj.org/toc/1424-8247Through the years, many promising tools for gene editing have been developed including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), CRISPR-associated protein 9 (Cas9), and homing endonucleases (HEs). These novel technologies are now leading new scientific advancements and practical applications at an inimitable speed. While most work has been performed in eukaryotes, CRISPR systems also enable tools to understand and engineer bacteria. The increase in the number of multi-drug resistant strains highlights a necessity for more innovative approaches to the diagnosis and treatment of infections. CRISPR has given scientists a glimmer of hope in this area that can provide a novel tool to fight against antimicrobial resistance. This system can provide useful information about the functions of genes and aid us to find potential targets for antimicrobials. This paper discusses the emerging use of CRISPR-Cas systems in the fields of clinical microbiology and infectious diseases with a particular emphasis on future prospects.Sahar SerajianEhsan AhmadpourSonia M. Rodrigues OliveiraMaria de Lourdes PereiraSiamak HeidarzadehMDPI AGarticleCRISPRgene editinginfectious diseasesantimicrobial resistanceparasitologyMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1171, p 1171 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CRISPR gene editing infectious diseases antimicrobial resistance parasitology Medicine R Pharmacy and materia medica RS1-441
spellingShingle	CRISPR gene editing infectious diseases antimicrobial resistance parasitology Medicine R Pharmacy and materia medica RS1-441 Sahar Serajian Ehsan Ahmadpour Sonia M. Rodrigues Oliveira Maria de Lourdes Pereira Siamak Heidarzadeh CRISPR-Cas Technology: Emerging Applications in Clinical Microbiology and Infectious Diseases
description	Through the years, many promising tools for gene editing have been developed including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), CRISPR-associated protein 9 (Cas9), and homing endonucleases (HEs). These novel technologies are now leading new scientific advancements and practical applications at an inimitable speed. While most work has been performed in eukaryotes, CRISPR systems also enable tools to understand and engineer bacteria. The increase in the number of multi-drug resistant strains highlights a necessity for more innovative approaches to the diagnosis and treatment of infections. CRISPR has given scientists a glimmer of hope in this area that can provide a novel tool to fight against antimicrobial resistance. This system can provide useful information about the functions of genes and aid us to find potential targets for antimicrobials. This paper discusses the emerging use of CRISPR-Cas systems in the fields of clinical microbiology and infectious diseases with a particular emphasis on future prospects.
format	article
author	Sahar Serajian Ehsan Ahmadpour Sonia M. Rodrigues Oliveira Maria de Lourdes Pereira Siamak Heidarzadeh
author_facet	Sahar Serajian Ehsan Ahmadpour Sonia M. Rodrigues Oliveira Maria de Lourdes Pereira Siamak Heidarzadeh
author_sort	Sahar Serajian
title	CRISPR-Cas Technology: Emerging Applications in Clinical Microbiology and Infectious Diseases
title_short	CRISPR-Cas Technology: Emerging Applications in Clinical Microbiology and Infectious Diseases
title_full	CRISPR-Cas Technology: Emerging Applications in Clinical Microbiology and Infectious Diseases
title_fullStr	CRISPR-Cas Technology: Emerging Applications in Clinical Microbiology and Infectious Diseases
title_full_unstemmed	CRISPR-Cas Technology: Emerging Applications in Clinical Microbiology and Infectious Diseases
title_sort	crispr-cas technology: emerging applications in clinical microbiology and infectious diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ed5081de19ea4c7fb466d5014f7e1f4f
work_keys_str_mv	AT saharserajian crisprcastechnologyemergingapplicationsinclinicalmicrobiologyandinfectiousdiseases AT ehsanahmadpour crisprcastechnologyemergingapplicationsinclinicalmicrobiologyandinfectiousdiseases AT soniamrodriguesoliveira crisprcastechnologyemergingapplicationsinclinicalmicrobiologyandinfectiousdiseases AT mariadelourdespereira crisprcastechnologyemergingapplicationsinclinicalmicrobiologyandinfectiousdiseases AT siamakheidarzadeh crisprcastechnologyemergingapplicationsinclinicalmicrobiologyandinfectiousdiseases
_version_	1718410869137735680

CRISPR-Cas Technology: Emerging Applications in Clinical Microbiology and Infectious Diseases

Ejemplares similares