OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs

Lineage master regulators induce differentiation and how the melanocyte master regulator Microphthalmia-associated transcription factor (MITF) is regulated is unclear. Here, the authors show that the pluripotency master regulator, OCT4, counteracts differentiation induced by MITF in mouse embryonic...

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Autores principales:	Danna Sheinboim, Itay Maza, Iris Dror, Shivang Parikh, Vladislav Krupalnik, Rachel E. Bell, Asaf Zviran, Yusuke Suita, Ofir Hakim, Yael Mandel-Gutfreund, Mehdi Khaled, Jacob H. Hanna, Carmit Levy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ed521430fca74360a559208e179b4ba2
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spelling	oai:doaj.org-article:ed521430fca74360a559208e179b4ba22021-12-02T14:41:18ZOCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs10.1038/s41467-017-01122-12041-1723https://doaj.org/article/ed521430fca74360a559208e179b4ba22017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01122-1https://doaj.org/toc/2041-1723Lineage master regulators induce differentiation and how the melanocyte master regulator Microphthalmia-associated transcription factor (MITF) is regulated is unclear. Here, the authors show that the pluripotency master regulator, OCT4, counteracts differentiation induced by MITF in mouse embryonic stem cells.Danna SheinboimItay MazaIris DrorShivang ParikhVladislav KrupalnikRachel E. BellAsaf ZviranYusuke SuitaOfir HakimYael Mandel-GutfreundMehdi KhaledJacob H. HannaCarmit LevyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Danna Sheinboim Itay Maza Iris Dror Shivang Parikh Vladislav Krupalnik Rachel E. Bell Asaf Zviran Yusuke Suita Ofir Hakim Yael Mandel-Gutfreund Mehdi Khaled Jacob H. Hanna Carmit Levy OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs
description	Lineage master regulators induce differentiation and how the melanocyte master regulator Microphthalmia-associated transcription factor (MITF) is regulated is unclear. Here, the authors show that the pluripotency master regulator, OCT4, counteracts differentiation induced by MITF in mouse embryonic stem cells.
format	article
author	Danna Sheinboim Itay Maza Iris Dror Shivang Parikh Vladislav Krupalnik Rachel E. Bell Asaf Zviran Yusuke Suita Ofir Hakim Yael Mandel-Gutfreund Mehdi Khaled Jacob H. Hanna Carmit Levy
author_facet	Danna Sheinboim Itay Maza Iris Dror Shivang Parikh Vladislav Krupalnik Rachel E. Bell Asaf Zviran Yusuke Suita Ofir Hakim Yael Mandel-Gutfreund Mehdi Khaled Jacob H. Hanna Carmit Levy
author_sort	Danna Sheinboim
title	OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs
title_short	OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs
title_full	OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs
title_fullStr	OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs
title_full_unstemmed	OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs
title_sort	oct4 impedes cell fate redirection by the melanocyte lineage master regulator mitf in mouse escs
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ed521430fca74360a559208e179b4ba2
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OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs

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