Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer

SPINK1 upregulation is found in ~10–25% of prostate cancers. Here, they show that whilst SPINK1 is transcriptionally repressed by androgen receptor and its co-repressor REST, it is upregulated after androgen-deprivation therapy, which leads to neuroendocrine differentiation of prostate cancer cells....

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Autores principales:	Ritika Tiwari, Nishat Manzar, Vipul Bhatia, Anjali Yadav, Mushtaq A. Nengroo, Dipak Datta, Shannon Carskadon, Nilesh Gupta, Michael Sigouros, Francesca Khani, Matti Poutanen, Amina Zoubeidi, Himisha Beltran, Nallasivam Palanisamy, Bushra Ateeq
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ed56d705553641adb43a60033adc4409
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spelling	oai:doaj.org-article:ed56d705553641adb43a60033adc44092021-12-02T17:32:44ZAndrogen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer10.1038/s41467-019-14184-02041-1723https://doaj.org/article/ed56d705553641adb43a60033adc44092020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14184-0https://doaj.org/toc/2041-1723SPINK1 upregulation is found in ~10–25% of prostate cancers. Here, they show that whilst SPINK1 is transcriptionally repressed by androgen receptor and its co-repressor REST, it is upregulated after androgen-deprivation therapy, which leads to neuroendocrine differentiation of prostate cancer cells.Ritika TiwariNishat ManzarVipul BhatiaAnjali YadavMushtaq A. NengrooDipak DattaShannon CarskadonNilesh GuptaMichael SigourosFrancesca KhaniMatti PoutanenAmina ZoubeidiHimisha BeltranNallasivam PalanisamyBushra AteeqNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ritika Tiwari Nishat Manzar Vipul Bhatia Anjali Yadav Mushtaq A. Nengroo Dipak Datta Shannon Carskadon Nilesh Gupta Michael Sigouros Francesca Khani Matti Poutanen Amina Zoubeidi Himisha Beltran Nallasivam Palanisamy Bushra Ateeq Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer
description	SPINK1 upregulation is found in ~10–25% of prostate cancers. Here, they show that whilst SPINK1 is transcriptionally repressed by androgen receptor and its co-repressor REST, it is upregulated after androgen-deprivation therapy, which leads to neuroendocrine differentiation of prostate cancer cells.
format	article
author	Ritika Tiwari Nishat Manzar Vipul Bhatia Anjali Yadav Mushtaq A. Nengroo Dipak Datta Shannon Carskadon Nilesh Gupta Michael Sigouros Francesca Khani Matti Poutanen Amina Zoubeidi Himisha Beltran Nallasivam Palanisamy Bushra Ateeq
author_facet	Ritika Tiwari Nishat Manzar Vipul Bhatia Anjali Yadav Mushtaq A. Nengroo Dipak Datta Shannon Carskadon Nilesh Gupta Michael Sigouros Francesca Khani Matti Poutanen Amina Zoubeidi Himisha Beltran Nallasivam Palanisamy Bushra Ateeq
author_sort	Ritika Tiwari
title	Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer
title_short	Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer
title_full	Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer
title_fullStr	Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer
title_full_unstemmed	Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer
title_sort	androgen deprivation upregulates spink1 expression and potentiates cellular plasticity in prostate cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ed56d705553641adb43a60033adc4409
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Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer

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