Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability

Abstract Food is a known primary role to the exposure of the drugs orally administered. Since each animal may have unique food taking pattern and it is difficult to manipulate the food taking to animals, there lacks rationalized protocol for the food effects in pre-clinic study. The objective of thi...

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Autores principales:	Guoqing Zhang, Caifen Wang, Li Wu, Jian Xu, Xiaoxiao Hu, Shailendra Shakya, Yuanzhi He, Xiaohong Ren, Weidong Chen, Jiwen Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed57a69ba6fe40368114c3d6b02a574b
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spelling	oai:doaj.org-article:ed57a69ba6fe40368114c3d6b02a574b2021-12-02T15:08:56ZIdentification of beagle food taking patterns and protocol for food effects evaluation on bioavailability10.1038/s41598-018-30937-12045-2322https://doaj.org/article/ed57a69ba6fe40368114c3d6b02a574b2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-30937-1https://doaj.org/toc/2045-2322Abstract Food is a known primary role to the exposure of the drugs orally administered. Since each animal may have unique food taking pattern and it is difficult to manipulate the food taking to animals, there lacks rationalized protocol for the food effects in pre-clinic study. The objective of this study was to identify the beagle food taking patterns and demonstrate their effects on bioavailability in valsartan. Herein, four types of food taking patterns of beagle were identified via inter-day and intra-day analysis, and named as Persisting, Pulsing, Postponing, Pushing (“4P Modes”), respectively, which were also validated by principal component analysis (PCA). Interestingly, food intake resulted in a reduced area under the concentration-time curve (AUC0–12h), maximum concentration (Cmax) and absorption rate, whilst the reduction varied in “4P Modes” of food taking. General considerations in the design of experiment for food effect to the bioavailability in beagles have been established as: to recognize the food taking patterns in each animal, to confirm the inter-day stability of the food taking behaviors, to trace the food taking patterns in parallel with plasma sampling. In conclusion, the right animals with proper food taking patterns should be assessed and selected for pre-clinic bioavailability evaluations.Guoqing ZhangCaifen WangLi WuJian XuXiaoxiao HuShailendra ShakyaYuanzhi HeXiaohong RenWeidong ChenJiwen ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guoqing Zhang Caifen Wang Li Wu Jian Xu Xiaoxiao Hu Shailendra Shakya Yuanzhi He Xiaohong Ren Weidong Chen Jiwen Zhang Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability
description	Abstract Food is a known primary role to the exposure of the drugs orally administered. Since each animal may have unique food taking pattern and it is difficult to manipulate the food taking to animals, there lacks rationalized protocol for the food effects in pre-clinic study. The objective of this study was to identify the beagle food taking patterns and demonstrate their effects on bioavailability in valsartan. Herein, four types of food taking patterns of beagle were identified via inter-day and intra-day analysis, and named as Persisting, Pulsing, Postponing, Pushing (“4P Modes”), respectively, which were also validated by principal component analysis (PCA). Interestingly, food intake resulted in a reduced area under the concentration-time curve (AUC0–12h), maximum concentration (Cmax) and absorption rate, whilst the reduction varied in “4P Modes” of food taking. General considerations in the design of experiment for food effect to the bioavailability in beagles have been established as: to recognize the food taking patterns in each animal, to confirm the inter-day stability of the food taking behaviors, to trace the food taking patterns in parallel with plasma sampling. In conclusion, the right animals with proper food taking patterns should be assessed and selected for pre-clinic bioavailability evaluations.
format	article
author	Guoqing Zhang Caifen Wang Li Wu Jian Xu Xiaoxiao Hu Shailendra Shakya Yuanzhi He Xiaohong Ren Weidong Chen Jiwen Zhang
author_facet	Guoqing Zhang Caifen Wang Li Wu Jian Xu Xiaoxiao Hu Shailendra Shakya Yuanzhi He Xiaohong Ren Weidong Chen Jiwen Zhang
author_sort	Guoqing Zhang
title	Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability
title_short	Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability
title_full	Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability
title_fullStr	Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability
title_full_unstemmed	Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability
title_sort	identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ed57a69ba6fe40368114c3d6b02a574b
work_keys_str_mv	AT guoqingzhang identificationofbeaglefoodtakingpatternsandprotocolforfoodeffectsevaluationonbioavailability AT caifenwang identificationofbeaglefoodtakingpatternsandprotocolforfoodeffectsevaluationonbioavailability AT liwu identificationofbeaglefoodtakingpatternsandprotocolforfoodeffectsevaluationonbioavailability AT jianxu identificationofbeaglefoodtakingpatternsandprotocolforfoodeffectsevaluationonbioavailability AT xiaoxiaohu identificationofbeaglefoodtakingpatternsandprotocolforfoodeffectsevaluationonbioavailability AT shailendrashakya identificationofbeaglefoodtakingpatternsandprotocolforfoodeffectsevaluationonbioavailability AT yuanzhihe identificationofbeaglefoodtakingpatternsandprotocolforfoodeffectsevaluationonbioavailability AT xiaohongren identificationofbeaglefoodtakingpatternsandprotocolforfoodeffectsevaluationonbioavailability AT weidongchen identificationofbeaglefoodtakingpatternsandprotocolforfoodeffectsevaluationonbioavailability AT jiwenzhang identificationofbeaglefoodtakingpatternsandprotocolforfoodeffectsevaluationonbioavailability
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Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability

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