Emerging Technologies to Study the Glomerular Filtration Barrier

Kidney disease is characterized by loss of glomerular function with clinical manifestation of proteinuria. Identifying the cellular and molecular changes that lead to loss of protein in the urine is challenging due to the complexity of the filtration barrier, constituted by podocytes, glomerular end...

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Autores principales:	Emma Gong, Laura Perin, Stefano Da Sacco, Sargis Sedrakyan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Proteinuria kidney disease single cell transcriptomics spatial transcriptomics kidney organoids kidney-on-a-chip Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ed5b68a904544b88804db61d4a1bfdca
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spelling	oai:doaj.org-article:ed5b68a904544b88804db61d4a1bfdca2021-12-01T01:00:19ZEmerging Technologies to Study the Glomerular Filtration Barrier2296-858X10.3389/fmed.2021.772883https://doaj.org/article/ed5b68a904544b88804db61d4a1bfdca2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.772883/fullhttps://doaj.org/toc/2296-858XKidney disease is characterized by loss of glomerular function with clinical manifestation of proteinuria. Identifying the cellular and molecular changes that lead to loss of protein in the urine is challenging due to the complexity of the filtration barrier, constituted by podocytes, glomerular endothelial cells, and glomerular basement membrane. In this review, we will discuss how technologies like single cell RNA sequencing and bioinformatics-based spatial transcriptomics, as well as in vitro systems like kidney organoids and the glomerulus-on-a-chip, have contributed to our understanding of glomerular pathophysiology. Knowledge gained from these studies will contribute toward the development of personalized therapeutic approaches for patients affected by proteinuric diseases.Emma GongLaura PerinLaura PerinStefano Da SaccoStefano Da SaccoSargis SedrakyanSargis SedrakyanFrontiers Media S.A.articleProteinuriakidney diseasesingle cell transcriptomicsspatial transcriptomicskidney organoidskidney-on-a-chipMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Proteinuria kidney disease single cell transcriptomics spatial transcriptomics kidney organoids kidney-on-a-chip Medicine (General) R5-920
spellingShingle	Proteinuria kidney disease single cell transcriptomics spatial transcriptomics kidney organoids kidney-on-a-chip Medicine (General) R5-920 Emma Gong Laura Perin Laura Perin Stefano Da Sacco Stefano Da Sacco Sargis Sedrakyan Sargis Sedrakyan Emerging Technologies to Study the Glomerular Filtration Barrier
description	Kidney disease is characterized by loss of glomerular function with clinical manifestation of proteinuria. Identifying the cellular and molecular changes that lead to loss of protein in the urine is challenging due to the complexity of the filtration barrier, constituted by podocytes, glomerular endothelial cells, and glomerular basement membrane. In this review, we will discuss how technologies like single cell RNA sequencing and bioinformatics-based spatial transcriptomics, as well as in vitro systems like kidney organoids and the glomerulus-on-a-chip, have contributed to our understanding of glomerular pathophysiology. Knowledge gained from these studies will contribute toward the development of personalized therapeutic approaches for patients affected by proteinuric diseases.
format	article
author	Emma Gong Laura Perin Laura Perin Stefano Da Sacco Stefano Da Sacco Sargis Sedrakyan Sargis Sedrakyan
author_facet	Emma Gong Laura Perin Laura Perin Stefano Da Sacco Stefano Da Sacco Sargis Sedrakyan Sargis Sedrakyan
author_sort	Emma Gong
title	Emerging Technologies to Study the Glomerular Filtration Barrier
title_short	Emerging Technologies to Study the Glomerular Filtration Barrier
title_full	Emerging Technologies to Study the Glomerular Filtration Barrier
title_fullStr	Emerging Technologies to Study the Glomerular Filtration Barrier
title_full_unstemmed	Emerging Technologies to Study the Glomerular Filtration Barrier
title_sort	emerging technologies to study the glomerular filtration barrier
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ed5b68a904544b88804db61d4a1bfdca
work_keys_str_mv	AT emmagong emergingtechnologiestostudytheglomerularfiltrationbarrier AT lauraperin emergingtechnologiestostudytheglomerularfiltrationbarrier AT lauraperin emergingtechnologiestostudytheglomerularfiltrationbarrier AT stefanodasacco emergingtechnologiestostudytheglomerularfiltrationbarrier AT stefanodasacco emergingtechnologiestostudytheglomerularfiltrationbarrier AT sargissedrakyan emergingtechnologiestostudytheglomerularfiltrationbarrier AT sargissedrakyan emergingtechnologiestostudytheglomerularfiltrationbarrier
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Emerging Technologies to Study the Glomerular Filtration Barrier

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