Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks

Immune cells express immunoproteasomes (i20S), which bind to specialized regulators, contain different catalytic subunits and generate immunogenic peptides. HDX-MS—based assessment of the differences between the conformational dynamics of standard and i20s reveals specific, allosteric changes in i20...

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Autores principales: Jean Lesne, Marie Locard-Paulet, Julien Parra, Dušan Zivković, Thomas Menneteau, Marie-Pierre Bousquet, Odile Burlet-Schiltz, Julien Marcoux
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/ed5d484ebb094784a4e9cc4583e3d0aa
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Sumario:Immune cells express immunoproteasomes (i20S), which bind to specialized regulators, contain different catalytic subunits and generate immunogenic peptides. HDX-MS—based assessment of the differences between the conformational dynamics of standard and i20s reveals specific, allosteric changes in i20S and upon regulator binding.