Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks

Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks

Immune cells express immunoproteasomes (i20S), which bind to specialized regulators, contain different catalytic subunits and generate immunogenic peptides. HDX-MS—based assessment of the differences between the conformational dynamics of standard and i20s reveals specific, allosteric changes in i20...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jean Lesne, Marie Locard-Paulet, Julien Parra, Dušan Zivković, Thomas Menneteau, Marie-Pierre Bousquet, Odile Burlet-Schiltz, Julien Marcoux
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/ed5d484ebb094784a4e9cc4583e3d0aa
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:ed5d484ebb094784a4e9cc4583e3d0aa
record_format dspace
spelling oai:doaj.org-article:ed5d484ebb094784a4e9cc4583e3d0aa2021-12-02T15:39:22ZConformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks10.1038/s41467-020-19934-z2041-1723https://doaj.org/article/ed5d484ebb094784a4e9cc4583e3d0aa2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19934-zhttps://doaj.org/toc/2041-1723Immune cells express immunoproteasomes (i20S), which bind to specialized regulators, contain different catalytic subunits and generate immunogenic peptides. HDX-MS—based assessment of the differences between the conformational dynamics of standard and i20s reveals specific, allosteric changes in i20S and upon regulator binding.Jean LesneMarie Locard-PauletJulien ParraDušan ZivkovićThomas MenneteauMarie-Pierre BousquetOdile Burlet-SchiltzJulien MarcouxNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jean Lesne
Marie Locard-Paulet
Julien Parra
Dušan Zivković
Thomas Menneteau
Marie-Pierre Bousquet
Odile Burlet-Schiltz
Julien Marcoux
Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks
description Immune cells express immunoproteasomes (i20S), which bind to specialized regulators, contain different catalytic subunits and generate immunogenic peptides. HDX-MS—based assessment of the differences between the conformational dynamics of standard and i20s reveals specific, allosteric changes in i20S and upon regulator binding.
format article
author Jean Lesne
Marie Locard-Paulet
Julien Parra
Dušan Zivković
Thomas Menneteau
Marie-Pierre Bousquet
Odile Burlet-Schiltz
Julien Marcoux
author_facet Jean Lesne
Marie Locard-Paulet
Julien Parra
Dušan Zivković
Thomas Menneteau
Marie-Pierre Bousquet
Odile Burlet-Schiltz
Julien Marcoux
author_sort Jean Lesne
title Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks
title_short Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks
title_full Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks
title_fullStr Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks
title_full_unstemmed Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks
title_sort conformational maps of human 20s proteasomes reveal pa28- and immuno-dependent inter-ring crosstalks
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/ed5d484ebb094784a4e9cc4583e3d0aa
work_keys_str_mv AT jeanlesne conformationalmapsofhuman20sproteasomesrevealpa28andimmunodependentinterringcrosstalks
AT marielocardpaulet conformationalmapsofhuman20sproteasomesrevealpa28andimmunodependentinterringcrosstalks
AT julienparra conformationalmapsofhuman20sproteasomesrevealpa28andimmunodependentinterringcrosstalks
AT dusanzivkovic conformationalmapsofhuman20sproteasomesrevealpa28andimmunodependentinterringcrosstalks
AT thomasmenneteau conformationalmapsofhuman20sproteasomesrevealpa28andimmunodependentinterringcrosstalks
AT mariepierrebousquet conformationalmapsofhuman20sproteasomesrevealpa28andimmunodependentinterringcrosstalks
AT odileburletschiltz conformationalmapsofhuman20sproteasomesrevealpa28andimmunodependentinterringcrosstalks
AT julienmarcoux conformationalmapsofhuman20sproteasomesrevealpa28andimmunodependentinterringcrosstalks
_version_ 1718385965795377152

Ejemplares similares