Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks
Immune cells express immunoproteasomes (i20S), which bind to specialized regulators, contain different catalytic subunits and generate immunogenic peptides. HDX-MS—based assessment of the differences between the conformational dynamics of standard and i20s reveals specific, allosteric changes in i20...
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Autores principales: | Jean Lesne, Marie Locard-Paulet, Julien Parra, Dušan Zivković, Thomas Menneteau, Marie-Pierre Bousquet, Odile Burlet-Schiltz, Julien Marcoux |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
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Materias: | |
Acceso en línea: | https://doaj.org/article/ed5d484ebb094784a4e9cc4583e3d0aa |
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