Elastic liposomes as novel carriers: recent advances in drug delivery

Afzal Hussain,1,2 Sima Singh,1 Dinesh Sharma,3 Thomas J Webster,4 Kausar Shafaat,2 Abdul Faruk5 1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India; 2Faculty of Pharmacy, Sachchidananda Sinha College, Aurangabad, Bihar, Indi...

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Autores principales:	Hussain A, Singh S, Sharma D, Webster TJ, Shafaat K, Faruk A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Elastic liposomes Drug delivery Topical Transdermal and Enhanced delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ed5d486f16cf4b81801f0f036fd09b4b
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spelling	oai:doaj.org-article:ed5d486f16cf4b81801f0f036fd09b4b2021-12-02T02:01:30ZElastic liposomes as novel carriers: recent advances in drug delivery1178-2013https://doaj.org/article/ed5d486f16cf4b81801f0f036fd09b4b2017-07-01T00:00:00Zhttps://www.dovepress.com/elastic-liposomes-as-novel-carriers-recent-advances-in-drug-delivery-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Afzal Hussain,1,2 Sima Singh,1 Dinesh Sharma,3 Thomas J Webster,4 Kausar Shafaat,2 Abdul Faruk5 1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India; 2Faculty of Pharmacy, Sachchidananda Sinha College, Aurangabad, Bihar, India; 3Zifam Pyrex Myanmar Co. Ltd., Yangon, Myanmar; 4Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 5Department of Pharmaceutical Sciences, Hemwati Nandan Bahuguna Garhwal University, Srinagar, Uttarakhand, India Abstract: Elastic liposomes (EL) are some of the most versatile deformable vesicular carriers that comprise physiologically biocompatible lipids and surfactants for the delivery of numerous challenging molecules and have marked advantages over other colloidal systems. They have been investigated for a wide range of applications in pharmaceutical technology through topical, transdermal, nasal, and oral routes for efficient and effective drug delivery. Increased drug encapsulation efficiency, enhanced drug permeation and penetration into or across the skin, and ultradeformability have led to widespread interest in ELs to modulate drug release, permeation, and drug action more efficiently than conventional drug-release vehicles. This review provides insights into the versatile role that ELs play in the delivery of numerous drugs and biomolecules by improving drug release, permeation, and penetration across the skin as well as stability. Furthermore, it provides future directions that should ensure the widespread use of ELs across all medical fields. Keywords: elastic liposomes, drug delivery, topical, transdermal, enhanced delivery Hussain ASingh SSharma DWebster TJShafaat KFaruk ADove Medical PressarticleElastic liposomesDrug deliveryTopicalTransdermaland Enhanced deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 5087-5108 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Elastic liposomes Drug delivery Topical Transdermal and Enhanced delivery Medicine (General) R5-920
spellingShingle	Elastic liposomes Drug delivery Topical Transdermal and Enhanced delivery Medicine (General) R5-920 Hussain A Singh S Sharma D Webster TJ Shafaat K Faruk A Elastic liposomes as novel carriers: recent advances in drug delivery
description	Afzal Hussain,1,2 Sima Singh,1 Dinesh Sharma,3 Thomas J Webster,4 Kausar Shafaat,2 Abdul Faruk5 1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India; 2Faculty of Pharmacy, Sachchidananda Sinha College, Aurangabad, Bihar, India; 3Zifam Pyrex Myanmar Co. Ltd., Yangon, Myanmar; 4Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 5Department of Pharmaceutical Sciences, Hemwati Nandan Bahuguna Garhwal University, Srinagar, Uttarakhand, India Abstract: Elastic liposomes (EL) are some of the most versatile deformable vesicular carriers that comprise physiologically biocompatible lipids and surfactants for the delivery of numerous challenging molecules and have marked advantages over other colloidal systems. They have been investigated for a wide range of applications in pharmaceutical technology through topical, transdermal, nasal, and oral routes for efficient and effective drug delivery. Increased drug encapsulation efficiency, enhanced drug permeation and penetration into or across the skin, and ultradeformability have led to widespread interest in ELs to modulate drug release, permeation, and drug action more efficiently than conventional drug-release vehicles. This review provides insights into the versatile role that ELs play in the delivery of numerous drugs and biomolecules by improving drug release, permeation, and penetration across the skin as well as stability. Furthermore, it provides future directions that should ensure the widespread use of ELs across all medical fields. Keywords: elastic liposomes, drug delivery, topical, transdermal, enhanced delivery
format	article
author	Hussain A Singh S Sharma D Webster TJ Shafaat K Faruk A
author_facet	Hussain A Singh S Sharma D Webster TJ Shafaat K Faruk A
author_sort	Hussain A
title	Elastic liposomes as novel carriers: recent advances in drug delivery
title_short	Elastic liposomes as novel carriers: recent advances in drug delivery
title_full	Elastic liposomes as novel carriers: recent advances in drug delivery
title_fullStr	Elastic liposomes as novel carriers: recent advances in drug delivery
title_full_unstemmed	Elastic liposomes as novel carriers: recent advances in drug delivery
title_sort	elastic liposomes as novel carriers: recent advances in drug delivery
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/ed5d486f16cf4b81801f0f036fd09b4b
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Elastic liposomes as novel carriers: recent advances in drug delivery

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