Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability

Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability

Japanese encephalitis virus (JEV) is a Flavivirus responsible for thousands of deaths every year for which there are no specific anti-virals. Here, Wang et al. report the cryo-EM structure of mature JEV at near-atomic resolution and identify structural elements that modulate stability and virulence.

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Bibliographic Details
Main Authors: Xiangxi Wang, Shi-Hua Li, Ling Zhu, Qing-Gong Nian, Shuai Yuan, Qiang Gao, Zhongyu Hu, Qing Ye, Xiao-Feng Li, Dong-Yang Xie, Neil Shaw, Junzhi Wang, Thomas S. Walter, Juha T. Huiskonen, Elizabeth E. Fry, Cheng-Feng Qin, David I. Stuart, Zihe Rao
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
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Online Access:https://doaj.org/article/ed5e43459e464ee6a6602a849e5c6e81
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Summary:Japanese encephalitis virus (JEV) is a Flavivirus responsible for thousands of deaths every year for which there are no specific anti-virals. Here, Wang et al. report the cryo-EM structure of mature JEV at near-atomic resolution and identify structural elements that modulate stability and virulence.

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