Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability
Japanese encephalitis virus (JEV) is a Flavivirus responsible for thousands of deaths every year for which there are no specific anti-virals. Here, Wang et al. report the cryo-EM structure of mature JEV at near-atomic resolution and identify structural elements that modulate stability and virulence.
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Nature Portfolio
2017
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oai:doaj.org-article:ed5e43459e464ee6a6602a849e5c6e812021-12-02T10:47:59ZNear-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability10.1038/s41467-017-00024-62041-1723https://doaj.org/article/ed5e43459e464ee6a6602a849e5c6e812017-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00024-6https://doaj.org/toc/2041-1723Japanese encephalitis virus (JEV) is a Flavivirus responsible for thousands of deaths every year for which there are no specific anti-virals. Here, Wang et al. report the cryo-EM structure of mature JEV at near-atomic resolution and identify structural elements that modulate stability and virulence.Xiangxi WangShi-Hua LiLing ZhuQing-Gong NianShuai YuanQiang GaoZhongyu HuQing YeXiao-Feng LiDong-Yang XieNeil ShawJunzhi WangThomas S. WalterJuha T. HuiskonenElizabeth E. FryCheng-Feng QinDavid I. StuartZihe RaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Xiangxi Wang Shi-Hua Li Ling Zhu Qing-Gong Nian Shuai Yuan Qiang Gao Zhongyu Hu Qing Ye Xiao-Feng Li Dong-Yang Xie Neil Shaw Junzhi Wang Thomas S. Walter Juha T. Huiskonen Elizabeth E. Fry Cheng-Feng Qin David I. Stuart Zihe Rao Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability |
| description |
Japanese encephalitis virus (JEV) is a Flavivirus responsible for thousands of deaths every year for which there are no specific anti-virals. Here, Wang et al. report the cryo-EM structure of mature JEV at near-atomic resolution and identify structural elements that modulate stability and virulence. |
| format |
article |
| author |
Xiangxi Wang Shi-Hua Li Ling Zhu Qing-Gong Nian Shuai Yuan Qiang Gao Zhongyu Hu Qing Ye Xiao-Feng Li Dong-Yang Xie Neil Shaw Junzhi Wang Thomas S. Walter Juha T. Huiskonen Elizabeth E. Fry Cheng-Feng Qin David I. Stuart Zihe Rao |
| author_facet |
Xiangxi Wang Shi-Hua Li Ling Zhu Qing-Gong Nian Shuai Yuan Qiang Gao Zhongyu Hu Qing Ye Xiao-Feng Li Dong-Yang Xie Neil Shaw Junzhi Wang Thomas S. Walter Juha T. Huiskonen Elizabeth E. Fry Cheng-Feng Qin David I. Stuart Zihe Rao |
| author_sort |
Xiangxi Wang |
| title |
Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability |
| title_short |
Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability |
| title_full |
Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability |
| title_fullStr |
Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability |
| title_full_unstemmed |
Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability |
| title_sort |
near-atomic structure of japanese encephalitis virus reveals critical determinants of virulence and stability |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/ed5e43459e464ee6a6602a849e5c6e81 |
| work_keys_str_mv |
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1718396739022487552 |