The Prognostic Value of LncRNA SLNCR1 in Cancers: A Meta-Analysis

Objective. This meta-analysis was performed to identify the prognostic value of SLNCR1 in multiple cancer types. Methods. Electronic databases, including PubMed, EMBASE, and Web of Science, Cochrane Library, Medline, BioMed Central, Springer, Science Direct, and China National Knowledge Internet (CN...

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Autores principales:	Lele Cong, Hongyan Sun, Miao Hao, Qian Sun, Yang Zheng, Xianling Cong, Rihua Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ed60cfedb3b44879baf26196f8d63cd7
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spelling	oai:doaj.org-article:ed60cfedb3b44879baf26196f8d63cd72021-11-08T02:35:19ZThe Prognostic Value of LncRNA SLNCR1 in Cancers: A Meta-Analysis1687-846910.1155/2021/3161714https://doaj.org/article/ed60cfedb3b44879baf26196f8d63cd72021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/3161714https://doaj.org/toc/1687-8469Objective. This meta-analysis was performed to identify the prognostic value of SLNCR1 in multiple cancer types. Methods. Electronic databases, including PubMed, EMBASE, and Web of Science, Cochrane Library, Medline, BioMed Central, Springer, Science Direct, and China National Knowledge Internet (CNKI), were searched for relevant studies up to August 2021, and the hazard ratios (HR) and 95% confidence intervals (95% CI) were calculated to assess the relationship between SLNCR1 expression and overall survival (OS). Results. 12 studies with a total of 1155 patients with 9 different types of cancers were included in this meta-analysis. The pooled HR indicates that high SLNCR1 expression represented poorer prognosis of cancer (HR = 2.11, 95% CI: 1.59–2.80, I2 = 0%, P<0.00001). Additionally, high SLNCR1 expression was correlated with TNM stage (odds ratio (OR): 1.72, 95% CI: 1.08–2.74, I2 = 62%, P=0.02), lymph node metastasis (LNM) (OR:2.42, 95% CI: 1.61–3.64, I2 = 55%, P<0.0001), and distant metastases (DM) (OR: 2.30, 95% CI: 1.50–3.55, I2 = 27%, P=0.0002). However, no evidence was found for a relationship between SLNCR1 expression and clinical features such as tumor size (OR: 1.71, 95% CI: 0.93–3.14, I2 = 71%, P=0.09), age (OR: 0.86, 95% CI: 0.68–1.08, I2 = 0%, P=0.19), or gender (OR: 1.07, 95% CI: 0.64–1.81, I2 = 55%, P=0.79). Conclusion. Our findings found that high SLNCR1 expression was associated with poor OS, advanced tumor stage, tumor size, LNM, and DM in multiple cancers, indicating that SLNCR1 may serve as a potential prognostic biomarker for cancer patients in China.Lele CongHongyan SunMiao HaoQian SunYang ZhengXianling CongRihua JiangHindawi LimitedarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Oncology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Lele Cong Hongyan Sun Miao Hao Qian Sun Yang Zheng Xianling Cong Rihua Jiang The Prognostic Value of LncRNA SLNCR1 in Cancers: A Meta-Analysis
description	Objective. This meta-analysis was performed to identify the prognostic value of SLNCR1 in multiple cancer types. Methods. Electronic databases, including PubMed, EMBASE, and Web of Science, Cochrane Library, Medline, BioMed Central, Springer, Science Direct, and China National Knowledge Internet (CNKI), were searched for relevant studies up to August 2021, and the hazard ratios (HR) and 95% confidence intervals (95% CI) were calculated to assess the relationship between SLNCR1 expression and overall survival (OS). Results. 12 studies with a total of 1155 patients with 9 different types of cancers were included in this meta-analysis. The pooled HR indicates that high SLNCR1 expression represented poorer prognosis of cancer (HR = 2.11, 95% CI: 1.59–2.80, I2 = 0%, P<0.00001). Additionally, high SLNCR1 expression was correlated with TNM stage (odds ratio (OR): 1.72, 95% CI: 1.08–2.74, I2 = 62%, P=0.02), lymph node metastasis (LNM) (OR:2.42, 95% CI: 1.61–3.64, I2 = 55%, P<0.0001), and distant metastases (DM) (OR: 2.30, 95% CI: 1.50–3.55, I2 = 27%, P=0.0002). However, no evidence was found for a relationship between SLNCR1 expression and clinical features such as tumor size (OR: 1.71, 95% CI: 0.93–3.14, I2 = 71%, P=0.09), age (OR: 0.86, 95% CI: 0.68–1.08, I2 = 0%, P=0.19), or gender (OR: 1.07, 95% CI: 0.64–1.81, I2 = 55%, P=0.79). Conclusion. Our findings found that high SLNCR1 expression was associated with poor OS, advanced tumor stage, tumor size, LNM, and DM in multiple cancers, indicating that SLNCR1 may serve as a potential prognostic biomarker for cancer patients in China.
format	article
author	Lele Cong Hongyan Sun Miao Hao Qian Sun Yang Zheng Xianling Cong Rihua Jiang
author_facet	Lele Cong Hongyan Sun Miao Hao Qian Sun Yang Zheng Xianling Cong Rihua Jiang
author_sort	Lele Cong
title	The Prognostic Value of LncRNA SLNCR1 in Cancers: A Meta-Analysis
title_short	The Prognostic Value of LncRNA SLNCR1 in Cancers: A Meta-Analysis
title_full	The Prognostic Value of LncRNA SLNCR1 in Cancers: A Meta-Analysis
title_fullStr	The Prognostic Value of LncRNA SLNCR1 in Cancers: A Meta-Analysis
title_full_unstemmed	The Prognostic Value of LncRNA SLNCR1 in Cancers: A Meta-Analysis
title_sort	prognostic value of lncrna slncr1 in cancers: a meta-analysis
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/ed60cfedb3b44879baf26196f8d63cd7
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The Prognostic Value of LncRNA SLNCR1 in Cancers: A Meta-Analysis

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