Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production

The mechanistic target of rapamycin (TOR) functions as an energy sensor and contributes to the control of glucose homeostasis. Here, the authors show that mTOR in the upper small intestine regulates hepatic glucose production and is required for the glucose lowering effect of metformin.

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Autores principales:	T. M. Zaved Waise, Mozhgan Rasti, Frank A. Duca, Song-Yang Zhang, Paige V. Bauer, Christopher J. Rhodes, Tony K. T. Lam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ed627460bddc4b5ba603759563251b83
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spelling	oai:doaj.org-article:ed627460bddc4b5ba603759563251b832021-12-02T17:02:01ZInhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production10.1038/s41467-019-08582-72041-1723https://doaj.org/article/ed627460bddc4b5ba603759563251b832019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08582-7https://doaj.org/toc/2041-1723The mechanistic target of rapamycin (TOR) functions as an energy sensor and contributes to the control of glucose homeostasis. Here, the authors show that mTOR in the upper small intestine regulates hepatic glucose production and is required for the glucose lowering effect of metformin.T. M. Zaved WaiseMozhgan RastiFrank A. DucaSong-Yang ZhangPaige V. BauerChristopher J. RhodesTony K. T. LamNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q T. M. Zaved Waise Mozhgan Rasti Frank A. Duca Song-Yang Zhang Paige V. Bauer Christopher J. Rhodes Tony K. T. Lam Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production
description	The mechanistic target of rapamycin (TOR) functions as an energy sensor and contributes to the control of glucose homeostasis. Here, the authors show that mTOR in the upper small intestine regulates hepatic glucose production and is required for the glucose lowering effect of metformin.
format	article
author	T. M. Zaved Waise Mozhgan Rasti Frank A. Duca Song-Yang Zhang Paige V. Bauer Christopher J. Rhodes Tony K. T. Lam
author_facet	T. M. Zaved Waise Mozhgan Rasti Frank A. Duca Song-Yang Zhang Paige V. Bauer Christopher J. Rhodes Tony K. T. Lam
author_sort	T. M. Zaved Waise
title	Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production
title_short	Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production
title_full	Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production
title_fullStr	Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production
title_full_unstemmed	Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production
title_sort	inhibition of upper small intestinal mtor lowers plasma glucose levels by inhibiting glucose production
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ed627460bddc4b5ba603759563251b83
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Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production

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