Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production

The mechanistic target of rapamycin (TOR) functions as an energy sensor and contributes to the control of glucose homeostasis. Here, the authors show that mTOR in the upper small intestine regulates hepatic glucose production and is required for the glucose lowering effect of metformin.

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Autores principales: T. M. Zaved Waise, Mozhgan Rasti, Frank A. Duca, Song-Yang Zhang, Paige V. Bauer, Christopher J. Rhodes, Tony K. T. Lam
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/ed627460bddc4b5ba603759563251b83
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