Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

STING is considered central to antiviral immunity via induction of type 1 interferons, but can also activate autophagy. Here the authors made two mice with different STING mutations that differentially affect these antiviral responses, and surprisingly show that inhibiting STING-dependent type 1 int...

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Autores principales:	Lívia H. Yamashiro, Stephen C. Wilson, Huntly M. Morrison, Vasiliki Karalis, Jing-Yi J. Chung, Katherine J. Chen, Helen S. Bateup, Moriah L. Szpara, Angus Y. Lee, Jeffery S. Cox, Russell E. Vance
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ed627a1b0d98493cb43197c2fade35f0
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spelling	oai:doaj.org-article:ed627a1b0d98493cb43197c2fade35f02021-12-02T15:23:00ZInterferon-independent STING signaling promotes resistance to HSV-1 in vivo10.1038/s41467-020-17156-x2041-1723https://doaj.org/article/ed627a1b0d98493cb43197c2fade35f02020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17156-xhttps://doaj.org/toc/2041-1723STING is considered central to antiviral immunity via induction of type 1 interferons, but can also activate autophagy. Here the authors made two mice with different STING mutations that differentially affect these antiviral responses, and surprisingly show that inhibiting STING-dependent type 1 interferon production does not affect susceptibility to HSV-1 infection.Lívia H. YamashiroStephen C. WilsonHuntly M. MorrisonVasiliki KaralisJing-Yi J. ChungKatherine J. ChenHelen S. BateupMoriah L. SzparaAngus Y. LeeJeffery S. CoxRussell E. VanceNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lívia H. Yamashiro Stephen C. Wilson Huntly M. Morrison Vasiliki Karalis Jing-Yi J. Chung Katherine J. Chen Helen S. Bateup Moriah L. Szpara Angus Y. Lee Jeffery S. Cox Russell E. Vance Interferon-independent STING signaling promotes resistance to HSV-1 in vivo
description	STING is considered central to antiviral immunity via induction of type 1 interferons, but can also activate autophagy. Here the authors made two mice with different STING mutations that differentially affect these antiviral responses, and surprisingly show that inhibiting STING-dependent type 1 interferon production does not affect susceptibility to HSV-1 infection.
format	article
author	Lívia H. Yamashiro Stephen C. Wilson Huntly M. Morrison Vasiliki Karalis Jing-Yi J. Chung Katherine J. Chen Helen S. Bateup Moriah L. Szpara Angus Y. Lee Jeffery S. Cox Russell E. Vance
author_facet	Lívia H. Yamashiro Stephen C. Wilson Huntly M. Morrison Vasiliki Karalis Jing-Yi J. Chung Katherine J. Chen Helen S. Bateup Moriah L. Szpara Angus Y. Lee Jeffery S. Cox Russell E. Vance
author_sort	Lívia H. Yamashiro
title	Interferon-independent STING signaling promotes resistance to HSV-1 in vivo
title_short	Interferon-independent STING signaling promotes resistance to HSV-1 in vivo
title_full	Interferon-independent STING signaling promotes resistance to HSV-1 in vivo
title_fullStr	Interferon-independent STING signaling promotes resistance to HSV-1 in vivo
title_full_unstemmed	Interferon-independent STING signaling promotes resistance to HSV-1 in vivo
title_sort	interferon-independent sting signaling promotes resistance to hsv-1 in vivo
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ed627a1b0d98493cb43197c2fade35f0
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Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

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