Risk factors of ventilator-associated pneumonia in elderly patients receiving mechanical ventilation

Yue Xu,1 Chunyun Lai,2 Guogang Xu,3 Wenwen Meng,3 Jie Zhang,1 Huiru Hou,4,* Hongying Pi1,*1Department of Nursing, Chinese People’s Liberation Army (PLA) General Hospital, Chinese PLA Medical Academy, Beijing, People’s Republic of China; 2Department of Respiratory, The Second Medi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xu Y, Lai C, Xu G, Meng W, Zhang J, Hou H, Pi H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	aged 80 and over pneumonia ventilator-associated risk factors； prediction model Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/ed6326f6791f41a48a4784572f3e6ebc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ed6326f6791f41a48a4784572f3e6ebc
record_format	dspace
spelling	oai:doaj.org-article:ed6326f6791f41a48a4784572f3e6ebc2021-12-02T07:19:58ZRisk factors of ventilator-associated pneumonia in elderly patients receiving mechanical ventilation1178-1998https://doaj.org/article/ed6326f6791f41a48a4784572f3e6ebc2019-06-01T00:00:00Zhttps://www.dovepress.com/risk-factors-of-ventilator-associated-pneumonia-in-elderly-patients-re-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Yue Xu,1 Chunyun Lai,2 Guogang Xu,3 Wenwen Meng,3 Jie Zhang,1 Huiru Hou,4,* Hongying Pi1,1Department of Nursing, Chinese People’s Liberation Army (PLA) General Hospital, Chinese PLA Medical Academy, Beijing, People’s Republic of China; 2Department of Respiratory, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of China; 3The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of China; 4Department of Nursing, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of ChinaThese authors contributed equally to this work Purpose: The aim of this study was to verify the potential risk factors of ventilator-associated pneumonia (VAP) in elderly Chinese patients receiving mechanical ventilation (MV). The secondary aim of this study was to present logistical regression prediction models of VAP occurrence in elderly Chinese patients receiving MV.Methods: Patients (aged 80 years or above) receiving MV for ≥48 h were enrolled from the Chinese People’s Liberation Army (PLA) General Hospital from January 2011 to December 2015. A chi-squared test and Mann–Whitney U-test were used to compare the data between participants with VAP and without VAP. Univariate logistic regression models were performed to explore the relationship between risk factors and VAP.Results: A total of 901 patients were included in the study, of which 156 were diagnosed as VAP (17.3%). The incidence density of VAP was 4.25/1,000 ventilator days. Logistic regression analysis showed that the independent risk factors for elderly patients with VAP were COPD (OR =1.526, P <0.05), intensive care unit (ICU) admission (OR=1.947, P <0.01), the MV methods (P <0.023), the number of antibiotics administered (OR=4.947, P <0.01), the number of central venous catheters (OR=1.809, P <0.05), the duration of indwelling urinary catheter (OR=1.805, P <0.01) and the use of corticosteroids prior to MV (OR=1.618, P <0.05). Logistic regression prediction model of VAP occurrence in the Chinese elderly patients with mechanical ventilation:Logit (P) = (−6.468) + 0.423X1 + 0.666X2 + 0.871X3 + (−0.501)X5 + 0.122X6 + 0.593X7 + 0.590X8 + 1.599X9.Conclusion: VAP occurrence is associated with a variety of controllable factors including the MV methods and the number of antibiotics administered. A model was established to predict VAP occurrence so that high-risk patients could be identified as early as possible.Keywords: aged, 80 and over, pneumonia, ventilator-associated, risk factors, prediction model  Xu YLai CXu GMeng WZhang JHou HPi HDove Medical Pressarticleaged80 and overpneumoniaventilator-associatedrisk factors； prediction modelGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 1027-1038 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	aged 80 and over pneumonia ventilator-associated risk factors； prediction model Geriatrics RC952-954.6
spellingShingle	aged 80 and over pneumonia ventilator-associated risk factors； prediction model Geriatrics RC952-954.6 Xu Y Lai C Xu G Meng W Zhang J Hou H Pi H Risk factors of ventilator-associated pneumonia in elderly patients receiving mechanical ventilation
description	Yue Xu,1 Chunyun Lai,2 Guogang Xu,3 Wenwen Meng,3 Jie Zhang,1 Huiru Hou,4,* Hongying Pi1,1Department of Nursing, Chinese People’s Liberation Army (PLA) General Hospital, Chinese PLA Medical Academy, Beijing, People’s Republic of China; 2Department of Respiratory, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of China; 3The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of China; 4Department of Nursing, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of ChinaThese authors contributed equally to this work Purpose: The aim of this study was to verify the potential risk factors of ventilator-associated pneumonia (VAP) in elderly Chinese patients receiving mechanical ventilation (MV). The secondary aim of this study was to present logistical regression prediction models of VAP occurrence in elderly Chinese patients receiving MV.Methods: Patients (aged 80 years or above) receiving MV for ≥48 h were enrolled from the Chinese People’s Liberation Army (PLA) General Hospital from January 2011 to December 2015. A chi-squared test and Mann–Whitney U-test were used to compare the data between participants with VAP and without VAP. Univariate logistic regression models were performed to explore the relationship between risk factors and VAP.Results: A total of 901 patients were included in the study, of which 156 were diagnosed as VAP (17.3%). The incidence density of VAP was 4.25/1,000 ventilator days. Logistic regression analysis showed that the independent risk factors for elderly patients with VAP were COPD (OR =1.526, P <0.05), intensive care unit (ICU) admission (OR=1.947, P <0.01), the MV methods (P <0.023), the number of antibiotics administered (OR=4.947, P <0.01), the number of central venous catheters (OR=1.809, P <0.05), the duration of indwelling urinary catheter (OR=1.805, P <0.01) and the use of corticosteroids prior to MV (OR=1.618, P <0.05). Logistic regression prediction model of VAP occurrence in the Chinese elderly patients with mechanical ventilation:Logit (P) = (−6.468) + 0.423X1 + 0.666X2 + 0.871X3 + (−0.501)X5 + 0.122X6 + 0.593X7 + 0.590X8 + 1.599X9.Conclusion: VAP occurrence is associated with a variety of controllable factors including the MV methods and the number of antibiotics administered. A model was established to predict VAP occurrence so that high-risk patients could be identified as early as possible.Keywords: aged, 80 and over, pneumonia, ventilator-associated, risk factors, prediction model
format	article
author	Xu Y Lai C Xu G Meng W Zhang J Hou H Pi H
author_facet	Xu Y Lai C Xu G Meng W Zhang J Hou H Pi H
author_sort	Xu Y
title	Risk factors of ventilator-associated pneumonia in elderly patients receiving mechanical ventilation
title_short	Risk factors of ventilator-associated pneumonia in elderly patients receiving mechanical ventilation
title_full	Risk factors of ventilator-associated pneumonia in elderly patients receiving mechanical ventilation
title_fullStr	Risk factors of ventilator-associated pneumonia in elderly patients receiving mechanical ventilation
title_full_unstemmed	Risk factors of ventilator-associated pneumonia in elderly patients receiving mechanical ventilation
title_sort	risk factors of ventilator-associated pneumonia in elderly patients receiving mechanical ventilation
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/ed6326f6791f41a48a4784572f3e6ebc
work_keys_str_mv	AT xuy riskfactorsofventilatorassociatedpneumoniainelderlypatientsreceivingmechanicalventilation AT laic riskfactorsofventilatorassociatedpneumoniainelderlypatientsreceivingmechanicalventilation AT xug riskfactorsofventilatorassociatedpneumoniainelderlypatientsreceivingmechanicalventilation AT mengw riskfactorsofventilatorassociatedpneumoniainelderlypatientsreceivingmechanicalventilation AT zhangj riskfactorsofventilatorassociatedpneumoniainelderlypatientsreceivingmechanicalventilation AT houh riskfactorsofventilatorassociatedpneumoniainelderlypatientsreceivingmechanicalventilation AT pih riskfactorsofventilatorassociatedpneumoniainelderlypatientsreceivingmechanicalventilation
_version_	1718399490724986880

Risk factors of ventilator-associated pneumonia in elderly patients receiving mechanical ventilation

Ejemplares similares