Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats.

Sea cucumber is widely consumed as a putative functional food. It contains many biologically-active substances, but only limited research on its properties in vivo has been done. The effects of different meals containing Isostichopus badionotus, a sea cucumber from southeast Mexico, on growth perfor...

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Autores principales:	Leticia Olivera-Castillo, Alberto Davalos, George Grant, Nina Valadez-Gonzalez, Jorge Montero, Hirian Alonso Moshe Barrera-Perez, Yasser Chim-Chi, Miguel Angel Olvera-Novoa, Víctor Ceja-Moreno, Pablo Acereto-Escoffie, Jorge Rubio-Piña, Rossanna Rodriguez-Canul
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed647d496144415b9c978040c54debbb
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spelling	oai:doaj.org-article:ed647d496144415b9c978040c54debbb2021-11-18T08:45:38ZDiets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats.1932-620310.1371/journal.pone.0079446https://doaj.org/article/ed647d496144415b9c978040c54debbb2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24260223/?tool=EBIhttps://doaj.org/toc/1932-6203Sea cucumber is widely consumed as a putative functional food. It contains many biologically-active substances, but only limited research on its properties in vivo has been done. The effects of different meals containing Isostichopus badionotus, a sea cucumber from southeast Mexico, on growth performance and body lipid profile in young rats were analyzed. Sea cucumber body wall was either lyophilized, cooked (100 °C, 1 h in water) and lyophilized, or oven-dried (70 °C for 12 h). It was then ground and incorporated into cholesterol-containing diets. I. badionotus meals supported growth and improved lipid profile in rats. In particular, serum cholesterol, low density lipoproteins, triglycerides concentration and atherogenic index values were greatly reduced by some I. badionotus containing diets. Liver total lipids, triglycerides and cholesterol were also reduced. Cooking or heat-treatment of the meals lowered but did not abolish their hypolipidemic potency. Gene expression analysis of several key genes involved in cholesterol and lipid metabolism in liver showed that diets containing I. badionotus repressed the induction of key genes associated with dyslipidemia exerted by cholesterol supplementation. Consumption of I. badionotus from the Yucatan Peninsula is beneficial for dyslipidemia, although biological effect is clearly dependent on preparation method.Leticia Olivera-CastilloAlberto DavalosGeorge GrantNina Valadez-GonzalezJorge MonteroHirian Alonso Moshe Barrera-PerezYasser Chim-ChiMiguel Angel Olvera-NovoaVíctor Ceja-MorenoPablo Acereto-EscoffieJorge Rubio-PiñaRossanna Rodriguez-CanulPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79446 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leticia Olivera-Castillo Alberto Davalos George Grant Nina Valadez-Gonzalez Jorge Montero Hirian Alonso Moshe Barrera-Perez Yasser Chim-Chi Miguel Angel Olvera-Novoa Víctor Ceja-Moreno Pablo Acereto-Escoffie Jorge Rubio-Piña Rossanna Rodriguez-Canul Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats.
description	Sea cucumber is widely consumed as a putative functional food. It contains many biologically-active substances, but only limited research on its properties in vivo has been done. The effects of different meals containing Isostichopus badionotus, a sea cucumber from southeast Mexico, on growth performance and body lipid profile in young rats were analyzed. Sea cucumber body wall was either lyophilized, cooked (100 °C, 1 h in water) and lyophilized, or oven-dried (70 °C for 12 h). It was then ground and incorporated into cholesterol-containing diets. I. badionotus meals supported growth and improved lipid profile in rats. In particular, serum cholesterol, low density lipoproteins, triglycerides concentration and atherogenic index values were greatly reduced by some I. badionotus containing diets. Liver total lipids, triglycerides and cholesterol were also reduced. Cooking or heat-treatment of the meals lowered but did not abolish their hypolipidemic potency. Gene expression analysis of several key genes involved in cholesterol and lipid metabolism in liver showed that diets containing I. badionotus repressed the induction of key genes associated with dyslipidemia exerted by cholesterol supplementation. Consumption of I. badionotus from the Yucatan Peninsula is beneficial for dyslipidemia, although biological effect is clearly dependent on preparation method.
format	article
author	Leticia Olivera-Castillo Alberto Davalos George Grant Nina Valadez-Gonzalez Jorge Montero Hirian Alonso Moshe Barrera-Perez Yasser Chim-Chi Miguel Angel Olvera-Novoa Víctor Ceja-Moreno Pablo Acereto-Escoffie Jorge Rubio-Piña Rossanna Rodriguez-Canul
author_facet	Leticia Olivera-Castillo Alberto Davalos George Grant Nina Valadez-Gonzalez Jorge Montero Hirian Alonso Moshe Barrera-Perez Yasser Chim-Chi Miguel Angel Olvera-Novoa Víctor Ceja-Moreno Pablo Acereto-Escoffie Jorge Rubio-Piña Rossanna Rodriguez-Canul
author_sort	Leticia Olivera-Castillo
title	Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats.
title_short	Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats.
title_full	Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats.
title_fullStr	Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats.
title_full_unstemmed	Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats.
title_sort	diets containing sea cucumber (isostichopus badionotus) meals are hypocholesterolemic in young rats.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ed647d496144415b9c978040c54debbb
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Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats.

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