Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence
Extracellular vesicles (EVs) in plasma can affect pathogenesis of parasites, but details remain unclear. Here, Toda et al. characterize plasma-derived EVs from Plasmodium vivax patients and show that PvEVs are preferentially taken up by human spleen fibroblasts, facilitating parasite cytoadherence.
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Nature Portfolio
2020
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oai:doaj.org-article:ed64effa50a745ce91636d1f3b6a2c542021-12-02T17:51:27ZPlasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence10.1038/s41467-020-16337-y2041-1723https://doaj.org/article/ed64effa50a745ce91636d1f3b6a2c542020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16337-yhttps://doaj.org/toc/2041-1723Extracellular vesicles (EVs) in plasma can affect pathogenesis of parasites, but details remain unclear. Here, Toda et al. characterize plasma-derived EVs from Plasmodium vivax patients and show that PvEVs are preferentially taken up by human spleen fibroblasts, facilitating parasite cytoadherence.Haruka TodaMiriam Diaz-VarelaJoan Segui-BarberWanlapa RoobsoongBarbara BaroSusana Garcia-SilvaAlicia GalianoMelisa Gualdrón-LópezAnne C. G. AlmeidaMarcelo A. M. BritoGisely Cardoso de MeloIris Aparici-HerraizCarlos Castro-CavadíaWuelton Marcelo MonteiroEva BorràsEduard SabidóIgor C. AlmeidaJakub ChojnackiJavier Martinez-PicadoMaria CalvoPilar ArmengolJaime Carmona-FonsecaMaria Fernanda YasnotRicardo LauzuricaAntonio MarcillaHector PeinadoMary R. GalinskiMarcus V. G. LacerdaJetsumon SattabongkotCarmen Fernandez-BecerraHernando A. del PortilloNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
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DOAJ |
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EN |
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Science Q |
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Science Q Haruka Toda Miriam Diaz-Varela Joan Segui-Barber Wanlapa Roobsoong Barbara Baro Susana Garcia-Silva Alicia Galiano Melisa Gualdrón-López Anne C. G. Almeida Marcelo A. M. Brito Gisely Cardoso de Melo Iris Aparici-Herraiz Carlos Castro-Cavadía Wuelton Marcelo Monteiro Eva Borràs Eduard Sabidó Igor C. Almeida Jakub Chojnacki Javier Martinez-Picado Maria Calvo Pilar Armengol Jaime Carmona-Fonseca Maria Fernanda Yasnot Ricardo Lauzurica Antonio Marcilla Hector Peinado Mary R. Galinski Marcus V. G. Lacerda Jetsumon Sattabongkot Carmen Fernandez-Becerra Hernando A. del Portillo Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence |
| description |
Extracellular vesicles (EVs) in plasma can affect pathogenesis of parasites, but details remain unclear. Here, Toda et al. characterize plasma-derived EVs from Plasmodium vivax patients and show that PvEVs are preferentially taken up by human spleen fibroblasts, facilitating parasite cytoadherence. |
| format |
article |
| author |
Haruka Toda Miriam Diaz-Varela Joan Segui-Barber Wanlapa Roobsoong Barbara Baro Susana Garcia-Silva Alicia Galiano Melisa Gualdrón-López Anne C. G. Almeida Marcelo A. M. Brito Gisely Cardoso de Melo Iris Aparici-Herraiz Carlos Castro-Cavadía Wuelton Marcelo Monteiro Eva Borràs Eduard Sabidó Igor C. Almeida Jakub Chojnacki Javier Martinez-Picado Maria Calvo Pilar Armengol Jaime Carmona-Fonseca Maria Fernanda Yasnot Ricardo Lauzurica Antonio Marcilla Hector Peinado Mary R. Galinski Marcus V. G. Lacerda Jetsumon Sattabongkot Carmen Fernandez-Becerra Hernando A. del Portillo |
| author_facet |
Haruka Toda Miriam Diaz-Varela Joan Segui-Barber Wanlapa Roobsoong Barbara Baro Susana Garcia-Silva Alicia Galiano Melisa Gualdrón-López Anne C. G. Almeida Marcelo A. M. Brito Gisely Cardoso de Melo Iris Aparici-Herraiz Carlos Castro-Cavadía Wuelton Marcelo Monteiro Eva Borràs Eduard Sabidó Igor C. Almeida Jakub Chojnacki Javier Martinez-Picado Maria Calvo Pilar Armengol Jaime Carmona-Fonseca Maria Fernanda Yasnot Ricardo Lauzurica Antonio Marcilla Hector Peinado Mary R. Galinski Marcus V. G. Lacerda Jetsumon Sattabongkot Carmen Fernandez-Becerra Hernando A. del Portillo |
| author_sort |
Haruka Toda |
| title |
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence |
| title_short |
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence |
| title_full |
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence |
| title_fullStr |
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence |
| title_full_unstemmed |
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence |
| title_sort |
plasma-derived extracellular vesicles from plasmodium vivax patients signal spleen fibroblasts via nf-kb facilitating parasite cytoadherence |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/ed64effa50a745ce91636d1f3b6a2c54 |
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