Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration

Abstract The purpose of this study was to quantitatively evaluate retinal pigment epithelium (RPE) changes in serous pigment epithelial detachment (PED) among patients with age-related macular degeneration by means of prototype multi-contrast optical coherence tomography (OCT), which is capable of s...

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Autores principales:	Masahiro Miura, Shuichi Makita, Yoshiaki Yasuno, Takuya Iwasaki, Shinnosuke Azuma, Toshihiro Mino, Tatsuo Yamaguchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed66aca2d70b4b0db735101fe61ab386
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spelling	oai:doaj.org-article:ed66aca2d70b4b0db735101fe61ab3862021-12-02T14:06:55ZEvaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration10.1038/s41598-021-82563-z2045-2322https://doaj.org/article/ed66aca2d70b4b0db735101fe61ab3862021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82563-zhttps://doaj.org/toc/2045-2322Abstract The purpose of this study was to quantitatively evaluate retinal pigment epithelium (RPE) changes in serous pigment epithelial detachment (PED) among patients with age-related macular degeneration by means of prototype multi-contrast optical coherence tomography (OCT), which is capable of simultaneous collection of OCT angiography, polarization-sensitive OCT, and standard OCT images. We evaluated 26 eyes of 21 patients with serous PED. RPE-melanin OCT images were calculated from the multi-contrast OCT dataset and compared with near-infrared autofluorescence images. An active RPE lesion was defined as an area of thickened RPE-melanin (≥ 70 μm; RPE70) on RPE-melanin OCT. Each PED area was divided into peak and slope regions. RPE70 area ratios were compared with the maximum PED height, PED area, PED volume, and slope area ratio (area of slope region/area of whole PED). RPE-melanin OCT images were consistent with near-infrared autofluorescence images. The RPE70 area ratio in the slope region was significantly negatively correlated with the slope area ratio. Development of active RPE lesions in the slope region was correlated with the PED configuration. Multi-contrast OCT is useful for objective evaluation of changes in the RPE in patients with age-related macular degeneration.Masahiro MiuraShuichi MakitaYoshiaki YasunoTakuya IwasakiShinnosuke AzumaToshihiro MinoTatsuo YamaguchiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masahiro Miura Shuichi Makita Yoshiaki Yasuno Takuya Iwasaki Shinnosuke Azuma Toshihiro Mino Tatsuo Yamaguchi Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration
description	Abstract The purpose of this study was to quantitatively evaluate retinal pigment epithelium (RPE) changes in serous pigment epithelial detachment (PED) among patients with age-related macular degeneration by means of prototype multi-contrast optical coherence tomography (OCT), which is capable of simultaneous collection of OCT angiography, polarization-sensitive OCT, and standard OCT images. We evaluated 26 eyes of 21 patients with serous PED. RPE-melanin OCT images were calculated from the multi-contrast OCT dataset and compared with near-infrared autofluorescence images. An active RPE lesion was defined as an area of thickened RPE-melanin (≥ 70 μm; RPE70) on RPE-melanin OCT. Each PED area was divided into peak and slope regions. RPE70 area ratios were compared with the maximum PED height, PED area, PED volume, and slope area ratio (area of slope region/area of whole PED). RPE-melanin OCT images were consistent with near-infrared autofluorescence images. The RPE70 area ratio in the slope region was significantly negatively correlated with the slope area ratio. Development of active RPE lesions in the slope region was correlated with the PED configuration. Multi-contrast OCT is useful for objective evaluation of changes in the RPE in patients with age-related macular degeneration.
format	article
author	Masahiro Miura Shuichi Makita Yoshiaki Yasuno Takuya Iwasaki Shinnosuke Azuma Toshihiro Mino Tatsuo Yamaguchi
author_facet	Masahiro Miura Shuichi Makita Yoshiaki Yasuno Takuya Iwasaki Shinnosuke Azuma Toshihiro Mino Tatsuo Yamaguchi
author_sort	Masahiro Miura
title	Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration
title_short	Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration
title_full	Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration
title_fullStr	Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration
title_full_unstemmed	Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration
title_sort	evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed66aca2d70b4b0db735101fe61ab386
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Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration

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