Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection

Karoyan et al. present a method to inhibit SARS-CoV-2 by means of a peptide-mimic approach. They design a series of peptides mimicking the N-terminal helix of hACE2 protein and their best peptide-mimic blocks SARS-CoV-2 human pulmonary cell infection with an IC50 in nanomolar range.

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Autores principales:	Philippe Karoyan, Vincent Vieillard, Luis Gómez-Morales, Estelle Odile, Amélie Guihot, Charles-Edouard Luyt, Alexis Denis, Pascal Grondin, Olivier Lequin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ed692f48c5844ca4b8d6abdcdfbbe19b
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spelling	oai:doaj.org-article:ed692f48c5844ca4b8d6abdcdfbbe19b2021-12-02T13:30:08ZHuman ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection10.1038/s42003-021-01736-82399-3642https://doaj.org/article/ed692f48c5844ca4b8d6abdcdfbbe19b2021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01736-8https://doaj.org/toc/2399-3642Karoyan et al. present a method to inhibit SARS-CoV-2 by means of a peptide-mimic approach. They design a series of peptides mimicking the N-terminal helix of hACE2 protein and their best peptide-mimic blocks SARS-CoV-2 human pulmonary cell infection with an IC50 in nanomolar range.Philippe KaroyanVincent VieillardLuis Gómez-MoralesEstelle OdileAmélie GuihotCharles-Edouard LuytAlexis DenisPascal GrondinOlivier LequinNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Philippe Karoyan Vincent Vieillard Luis Gómez-Morales Estelle Odile Amélie Guihot Charles-Edouard Luyt Alexis Denis Pascal Grondin Olivier Lequin Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection
description	Karoyan et al. present a method to inhibit SARS-CoV-2 by means of a peptide-mimic approach. They design a series of peptides mimicking the N-terminal helix of hACE2 protein and their best peptide-mimic blocks SARS-CoV-2 human pulmonary cell infection with an IC50 in nanomolar range.
format	article
author	Philippe Karoyan Vincent Vieillard Luis Gómez-Morales Estelle Odile Amélie Guihot Charles-Edouard Luyt Alexis Denis Pascal Grondin Olivier Lequin
author_facet	Philippe Karoyan Vincent Vieillard Luis Gómez-Morales Estelle Odile Amélie Guihot Charles-Edouard Luyt Alexis Denis Pascal Grondin Olivier Lequin
author_sort	Philippe Karoyan
title	Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection
title_short	Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection
title_full	Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection
title_fullStr	Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection
title_full_unstemmed	Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection
title_sort	human ace2 peptide-mimics block sars-cov-2 pulmonary cells infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed692f48c5844ca4b8d6abdcdfbbe19b
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Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection

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