Organic functionalization of single-walled carbon nanotubes (SWCNTs) with some chemotherapeutic agents as a potential method for drug delivery

Ardeshir Khazaei1, Mohammad Navid Soltani Rad2, Maryam Kiani Borazjani11Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran; 2Department of Chemistry, Faculty of Basic Sciences, Shiraz University of Technology, Shiraz, IranAbstract: The grafting of drugs to the single-walled carbon nanotube...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ardeshir Khazaei, Mohammad Navid Soltani Rad, Maryam Kiani Borazjani
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ed6c8cc6219343d3b5d0060744554623
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ed6c8cc6219343d3b5d0060744554623
record_format	dspace
spelling	oai:doaj.org-article:ed6c8cc6219343d3b5d00607445546232021-12-02T08:37:12ZOrganic functionalization of single-walled carbon nanotubes (SWCNTs) with some chemotherapeutic agents as a potential method for drug delivery1176-91141178-2013https://doaj.org/article/ed6c8cc6219343d3b5d00607445546232010-08-01T00:00:00Zhttp://www.dovepress.com/organic-functionalization-of-single-walled-carbon-nanotubes-swcnts-wit-a5152https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Ardeshir Khazaei1, Mohammad Navid Soltani Rad2, Maryam Kiani Borazjani11Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran; 2Department of Chemistry, Faculty of Basic Sciences, Shiraz University of Technology, Shiraz, IranAbstract: The grafting of drugs to the single-walled carbon nanotube (SWCNT) was attained by the initial conversion of carboxylic groups in SWCNT to corresponding acyl chlorides. The active acyl chlorides in SWCNT were subsequently mixed with chemotherapeutic agents having NH, NH2, and OH functional groups to afford the formation of relevant amide and ester, respectively. The covalently grafted drugs to SWCNT were identified by infrared and UV&ndash;visible spectroscopy and transmission electron microscopy methods. From a clinical aspect, the grafting of drugs to the SWCNT can be used as a new tool and useful method for potential drug delivery in patients.Keywords: grafting of drugs, solubilization Ardeshir KhazaeiMohammad Navid Soltani RadMaryam Kiani BorazjaniDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 639-645 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ardeshir Khazaei Mohammad Navid Soltani Rad Maryam Kiani Borazjani Organic functionalization of single-walled carbon nanotubes (SWCNTs) with some chemotherapeutic agents as a potential method for drug delivery
description	Ardeshir Khazaei1, Mohammad Navid Soltani Rad2, Maryam Kiani Borazjani11Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran; 2Department of Chemistry, Faculty of Basic Sciences, Shiraz University of Technology, Shiraz, IranAbstract: The grafting of drugs to the single-walled carbon nanotube (SWCNT) was attained by the initial conversion of carboxylic groups in SWCNT to corresponding acyl chlorides. The active acyl chlorides in SWCNT were subsequently mixed with chemotherapeutic agents having NH, NH2, and OH functional groups to afford the formation of relevant amide and ester, respectively. The covalently grafted drugs to SWCNT were identified by infrared and UV&ndash;visible spectroscopy and transmission electron microscopy methods. From a clinical aspect, the grafting of drugs to the SWCNT can be used as a new tool and useful method for potential drug delivery in patients.Keywords: grafting of drugs, solubilization
format	article
author	Ardeshir Khazaei Mohammad Navid Soltani Rad Maryam Kiani Borazjani
author_facet	Ardeshir Khazaei Mohammad Navid Soltani Rad Maryam Kiani Borazjani
author_sort	Ardeshir Khazaei
title	Organic functionalization of single-walled carbon nanotubes (SWCNTs) with some chemotherapeutic agents as a potential method for drug delivery
title_short	Organic functionalization of single-walled carbon nanotubes (SWCNTs) with some chemotherapeutic agents as a potential method for drug delivery
title_full	Organic functionalization of single-walled carbon nanotubes (SWCNTs) with some chemotherapeutic agents as a potential method for drug delivery
title_fullStr	Organic functionalization of single-walled carbon nanotubes (SWCNTs) with some chemotherapeutic agents as a potential method for drug delivery
title_full_unstemmed	Organic functionalization of single-walled carbon nanotubes (SWCNTs) with some chemotherapeutic agents as a potential method for drug delivery
title_sort	organic functionalization of single-walled carbon nanotubes (swcnts) with some chemotherapeutic agents as a potential method for drug delivery
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/ed6c8cc6219343d3b5d0060744554623
work_keys_str_mv	AT ardeshirkhazaei organicfunctionalizationofsinglewalledcarbonnanotubesswcntswithsomechemotherapeuticagentsasapotentialmethodfordrugdelivery AT mohammadnavidsoltanirad organicfunctionalizationofsinglewalledcarbonnanotubesswcntswithsomechemotherapeuticagentsasapotentialmethodfordrugdelivery AT maryamkianiborazjani organicfunctionalizationofsinglewalledcarbonnanotubesswcntswithsomechemotherapeuticagentsasapotentialmethodfordrugdelivery
_version_	1718398440100069376

Organic functionalization of single-walled carbon nanotubes (SWCNTs) with some chemotherapeutic agents as a potential method for drug delivery

Ejemplares similares