Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment

La Creis R Kidd,1,* Erica N Rogers,2,* Susan T Yeyeodu,2 Dominique Z Jones,1 K Sean Kimbro21Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 2Biomedical/Biotechnology Research Institute (BBRI), North Carolina Central University, Durham, NC, USA*These authors contr...

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Autores principales:	Kidd LR, Rogers EN, Yeyeodu ST, Jones DZ, Kimbro KS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ed6dd1ba7088411db73449e66b70316e
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spelling	oai:doaj.org-article:ed6dd1ba7088411db73449e66b70316e2021-12-02T08:47:37ZContribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment1179-1314https://doaj.org/article/ed6dd1ba7088411db73449e66b70316e2013-06-01T00:00:00Zhttp://www.dovepress.com/contribution-of-toll-like-receptor-signaling-pathways-to-breast-tumori-a13497https://doaj.org/toc/1179-1314La Creis R Kidd,1,* Erica N Rogers,2,* Susan T Yeyeodu,2 Dominique Z Jones,1 K Sean Kimbro21Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 2Biomedical/Biotechnology Research Institute (BBRI), North Carolina Central University, Durham, NC, USA*These authors contributed equally to this manuscript and are co-first authorsAbstract: Mounting evidence indicates that anomalies in the inflammatory and immune response pathways are essential to tumorigenesis. However, tumor-based innate immunity initiated by transformed breast epithelia tissues has received much less attention. This review summarizes published reports on the role of the toll-like receptor signaling pathway on breast cancer risk, disease progression, survival, and disease recurrence. Specifically, we discuss the underlying biological mechanisms that contribute to the tumorigenic and/or anti-tumorigenic properties of toll-like receptors and their associated agonists in relation to breast tumorigenesis and cancer treatment. Further, we use results from preclinical, clinical, and population-based studies as prompts for the exploration of new and more effective breast cancer therapies. As the knowledge base of innate immunity's involvement in breast cancer progression increases, current and new immune-modifying strategies will be refined to effectively treat breast cancer.Keywords: TLR, single nucleotide polymorphism, chemotherapy, radiotherapy, innate immunityKidd LRRogers ENYeyeodu STJones DZKimbro KSDove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2013, Iss default, Pp 43-51 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Kidd LR Rogers EN Yeyeodu ST Jones DZ Kimbro KS Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment
description	La Creis R Kidd,1,* Erica N Rogers,2,* Susan T Yeyeodu,2 Dominique Z Jones,1 K Sean Kimbro21Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 2Biomedical/Biotechnology Research Institute (BBRI), North Carolina Central University, Durham, NC, USA*These authors contributed equally to this manuscript and are co-first authorsAbstract: Mounting evidence indicates that anomalies in the inflammatory and immune response pathways are essential to tumorigenesis. However, tumor-based innate immunity initiated by transformed breast epithelia tissues has received much less attention. This review summarizes published reports on the role of the toll-like receptor signaling pathway on breast cancer risk, disease progression, survival, and disease recurrence. Specifically, we discuss the underlying biological mechanisms that contribute to the tumorigenic and/or anti-tumorigenic properties of toll-like receptors and their associated agonists in relation to breast tumorigenesis and cancer treatment. Further, we use results from preclinical, clinical, and population-based studies as prompts for the exploration of new and more effective breast cancer therapies. As the knowledge base of innate immunity's involvement in breast cancer progression increases, current and new immune-modifying strategies will be refined to effectively treat breast cancer.Keywords: TLR, single nucleotide polymorphism, chemotherapy, radiotherapy, innate immunity
format	article
author	Kidd LR Rogers EN Yeyeodu ST Jones DZ Kimbro KS
author_facet	Kidd LR Rogers EN Yeyeodu ST Jones DZ Kimbro KS
author_sort	Kidd LR
title	Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment
title_short	Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment
title_full	Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment
title_fullStr	Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment
title_full_unstemmed	Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment
title_sort	contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/ed6dd1ba7088411db73449e66b70316e
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Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment

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