Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice

The main function of skeletal muscles is to generate force. The force developed by myofiber contraction is transmitted to the tendon. There are two pathways of force transmission from myofibers to tendons: longitudinal transmission that depends on tension elicited via the myotendinous junction and l...

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Autores principales:	Keitaro Minato, Yuki Yoshimoto, Tamaki Kurosawa, Kei Watanabe, Hiroyuki Kawashima, Madoka Ikemoto-Uezumi, Akiyoshi Uezumi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	skeletal muscle lateral force transmission sarcopenia Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ed70a9c1e83346eb9fa531c6edbcf9b2
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spelling	oai:doaj.org-article:ed70a9c1e83346eb9fa531c6edbcf9b22021-11-25T17:55:40ZMeasurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice10.3390/ijms2222123561422-00671661-6596https://doaj.org/article/ed70a9c1e83346eb9fa531c6edbcf9b22021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12356https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The main function of skeletal muscles is to generate force. The force developed by myofiber contraction is transmitted to the tendon. There are two pathways of force transmission from myofibers to tendons: longitudinal transmission that depends on tension elicited via the myotendinous junction and lateral transmission that depends on shear elicited via the interface between the myofiber surface and surrounding connective tissue. Experiments using animal muscle and mathematical models indicated that lateral transmission is the dominant pathway in muscle force transmission. Studies using rat muscle showed that the efficiency of lateral force transmission declines with age. Here, the lateral transmission of force was measured using the extensor digitorum longus muscle from young and old mice. Dependence on longitudinal transmission increased in the old muscle, and there was a trend for lower efficiency of lateral force transmission in the old muscle compared to the young muscle. There was a noticeable increase in the connective tissue volume in the old muscle; however, there was no significant change in the expression of dystrophin, a critical molecule for the link between the myofiber cytoskeleton and extracellular matrix. This study demonstrates the measurement of lateral force transmission in mouse muscles and that alteration in force transmission property may underlie age-related muscle weakness.Keitaro MinatoYuki YoshimotoTamaki KurosawaKei WatanabeHiroyuki KawashimaMadoka Ikemoto-UezumiAkiyoshi UezumiMDPI AGarticleskeletal musclelateral force transmissionsarcopeniaBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12356, p 12356 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	skeletal muscle lateral force transmission sarcopenia Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	skeletal muscle lateral force transmission sarcopenia Biology (General) QH301-705.5 Chemistry QD1-999 Keitaro Minato Yuki Yoshimoto Tamaki Kurosawa Kei Watanabe Hiroyuki Kawashima Madoka Ikemoto-Uezumi Akiyoshi Uezumi Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice
description	The main function of skeletal muscles is to generate force. The force developed by myofiber contraction is transmitted to the tendon. There are two pathways of force transmission from myofibers to tendons: longitudinal transmission that depends on tension elicited via the myotendinous junction and lateral transmission that depends on shear elicited via the interface between the myofiber surface and surrounding connective tissue. Experiments using animal muscle and mathematical models indicated that lateral transmission is the dominant pathway in muscle force transmission. Studies using rat muscle showed that the efficiency of lateral force transmission declines with age. Here, the lateral transmission of force was measured using the extensor digitorum longus muscle from young and old mice. Dependence on longitudinal transmission increased in the old muscle, and there was a trend for lower efficiency of lateral force transmission in the old muscle compared to the young muscle. There was a noticeable increase in the connective tissue volume in the old muscle; however, there was no significant change in the expression of dystrophin, a critical molecule for the link between the myofiber cytoskeleton and extracellular matrix. This study demonstrates the measurement of lateral force transmission in mouse muscles and that alteration in force transmission property may underlie age-related muscle weakness.
format	article
author	Keitaro Minato Yuki Yoshimoto Tamaki Kurosawa Kei Watanabe Hiroyuki Kawashima Madoka Ikemoto-Uezumi Akiyoshi Uezumi
author_facet	Keitaro Minato Yuki Yoshimoto Tamaki Kurosawa Kei Watanabe Hiroyuki Kawashima Madoka Ikemoto-Uezumi Akiyoshi Uezumi
author_sort	Keitaro Minato
title	Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice
title_short	Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice
title_full	Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice
title_fullStr	Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice
title_full_unstemmed	Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice
title_sort	measurement of lateral transmission of force in the extensor digitorum longus muscle of young and old mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ed70a9c1e83346eb9fa531c6edbcf9b2
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Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice

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