Genome-Wide Landscape of North-Eastern European Populations: A View from Lithuania

There are still several unanswered questions regarding about ancient events in the Lithuanian population. The Lithuanians, as the subject of this study, are of great interest as they represent a partially isolated population maintaining an ancient genetic composition and show genetic uniqueness in E...

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Autores principales:	Alina Urnikyte, Alma Molyte, Vaidutis Kučinskas
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	population structure effective population size positive selection Balto-Slavic populations Genetics QH426-470
Acceso en línea:	https://doaj.org/article/ed70c3fdfe124c9cb74c3d1f6947a650
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spelling	oai:doaj.org-article:ed70c3fdfe124c9cb74c3d1f6947a6502021-11-25T17:41:19ZGenome-Wide Landscape of North-Eastern European Populations: A View from Lithuania10.3390/genes121117302073-4425https://doaj.org/article/ed70c3fdfe124c9cb74c3d1f6947a6502021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1730https://doaj.org/toc/2073-4425There are still several unanswered questions regarding about ancient events in the Lithuanian population. The Lithuanians, as the subject of this study, are of great interest as they represent a partially isolated population maintaining an ancient genetic composition and show genetic uniqueness in European comparisons. To elucidate the genetic relationships between the Lithuania and North-Eastern European and West Siberian populations, we analyzed the population structure, effective population size, and recent positive selection from genome-wide single nucleotide polymorphism (SNP) data. We identified the close genetic proximity of Lithuanians to neighboring populations (Latvians, Estonians, Belarusians) and in part with West and South Slavs (Poles, Slovaks, and Slovenians), however, with particular genetic distinctiveness. The estimated long-term <i>Ne</i> values ranged from ~5900 in the Estonian population to ~2400 in the South Russian population. The divergence times between the Lithuanian and study populations ranged from 240 to 12,871 YBP. We also found evidence of selection in 24 regions, 21 of which have not been discovered in previous analyses of selection. Undoubtedly, the genetic diversity analysis of geographically specific regions may provide new insights into microevolutionary processes affecting local human populations.Alina UrnikyteAlma MolyteVaidutis KučinskasMDPI AGarticlepopulation structureeffective population sizepositive selectionBalto-Slavic populationsGeneticsQH426-470ENGenes, Vol 12, Iss 1730, p 1730 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	population structure effective population size positive selection Balto-Slavic populations Genetics QH426-470
spellingShingle	population structure effective population size positive selection Balto-Slavic populations Genetics QH426-470 Alina Urnikyte Alma Molyte Vaidutis Kučinskas Genome-Wide Landscape of North-Eastern European Populations: A View from Lithuania
description	There are still several unanswered questions regarding about ancient events in the Lithuanian population. The Lithuanians, as the subject of this study, are of great interest as they represent a partially isolated population maintaining an ancient genetic composition and show genetic uniqueness in European comparisons. To elucidate the genetic relationships between the Lithuania and North-Eastern European and West Siberian populations, we analyzed the population structure, effective population size, and recent positive selection from genome-wide single nucleotide polymorphism (SNP) data. We identified the close genetic proximity of Lithuanians to neighboring populations (Latvians, Estonians, Belarusians) and in part with West and South Slavs (Poles, Slovaks, and Slovenians), however, with particular genetic distinctiveness. The estimated long-term <i>Ne</i> values ranged from ~5900 in the Estonian population to ~2400 in the South Russian population. The divergence times between the Lithuanian and study populations ranged from 240 to 12,871 YBP. We also found evidence of selection in 24 regions, 21 of which have not been discovered in previous analyses of selection. Undoubtedly, the genetic diversity analysis of geographically specific regions may provide new insights into microevolutionary processes affecting local human populations.
format	article
author	Alina Urnikyte Alma Molyte Vaidutis Kučinskas
author_facet	Alina Urnikyte Alma Molyte Vaidutis Kučinskas
author_sort	Alina Urnikyte
title	Genome-Wide Landscape of North-Eastern European Populations: A View from Lithuania
title_short	Genome-Wide Landscape of North-Eastern European Populations: A View from Lithuania
title_full	Genome-Wide Landscape of North-Eastern European Populations: A View from Lithuania
title_fullStr	Genome-Wide Landscape of North-Eastern European Populations: A View from Lithuania
title_full_unstemmed	Genome-Wide Landscape of North-Eastern European Populations: A View from Lithuania
title_sort	genome-wide landscape of north-eastern european populations: a view from lithuania
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ed70c3fdfe124c9cb74c3d1f6947a650
work_keys_str_mv	AT alinaurnikyte genomewidelandscapeofnortheasterneuropeanpopulationsaviewfromlithuania AT almamolyte genomewidelandscapeofnortheasterneuropeanpopulationsaviewfromlithuania AT vaidutiskucinskas genomewidelandscapeofnortheasterneuropeanpopulationsaviewfromlithuania
_version_	1718412139198152704

Genome-Wide Landscape of North-Eastern European Populations: A View from Lithuania

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