Contribution of hypoxia inducible factor-1 during viral infections
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs the formation of an active heterodimer in the n...
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Taylor & Francis Group
2020
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oai:doaj.org-article:ed70e18c4a6a4787be7aeb11fc0b7f412021-11-17T14:21:59ZContribution of hypoxia inducible factor-1 during viral infections2150-55942150-560810.1080/21505594.2020.1836904https://doaj.org/article/ed70e18c4a6a4787be7aeb11fc0b7f412020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1836904https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs the formation of an active heterodimer in the nucleus that otherwise regulates the expression of numerous genes. Importantly, HIF-1 participates in both cancer and infectious diseases unveiling new therapeutic targets for those ailments. Here, we discuss aspects related to the activation of HIF-1, the effects of this transcription factor over immune system components, as well as the involvement of HIF-1 activity in response to viral infections in humans. Although HIF-1 is currently being assessed in numerous clinical settings as a potential therapy for different diseases, up to date, there are no clinical studies evaluating the pharmacological modulation of this transcription factor as a possible new antiviral treatment. However, based on the available evidence, clinical trials targeting this molecule are likely to occur soon. In this review we discuss the role of HIF-1 in viral immunity, the modulation of HIF-1 by different types of viruses, as well as the effects of HIF-1 over their life cycle and the potential use of HIF-1 as a new target for the treatment of viral infections.Antonia ReyesNicolás CorralesNicolás M. S. GálvezSusan M. BuenoAlexis M. KalergisPablo A. GonzálezTaylor & Francis Grouparticlehypoxianormoxiarna virusesdna virusesvirus life cycleviral treatmentInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 1482-1500 (2020) |
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DOAJ |
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hypoxia normoxia rna viruses dna viruses virus life cycle viral treatment Infectious and parasitic diseases RC109-216 |
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hypoxia normoxia rna viruses dna viruses virus life cycle viral treatment Infectious and parasitic diseases RC109-216 Antonia Reyes Nicolás Corrales Nicolás M. S. Gálvez Susan M. Bueno Alexis M. Kalergis Pablo A. González Contribution of hypoxia inducible factor-1 during viral infections |
| description |
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs the formation of an active heterodimer in the nucleus that otherwise regulates the expression of numerous genes. Importantly, HIF-1 participates in both cancer and infectious diseases unveiling new therapeutic targets for those ailments. Here, we discuss aspects related to the activation of HIF-1, the effects of this transcription factor over immune system components, as well as the involvement of HIF-1 activity in response to viral infections in humans. Although HIF-1 is currently being assessed in numerous clinical settings as a potential therapy for different diseases, up to date, there are no clinical studies evaluating the pharmacological modulation of this transcription factor as a possible new antiviral treatment. However, based on the available evidence, clinical trials targeting this molecule are likely to occur soon. In this review we discuss the role of HIF-1 in viral immunity, the modulation of HIF-1 by different types of viruses, as well as the effects of HIF-1 over their life cycle and the potential use of HIF-1 as a new target for the treatment of viral infections. |
| format |
article |
| author |
Antonia Reyes Nicolás Corrales Nicolás M. S. Gálvez Susan M. Bueno Alexis M. Kalergis Pablo A. González |
| author_facet |
Antonia Reyes Nicolás Corrales Nicolás M. S. Gálvez Susan M. Bueno Alexis M. Kalergis Pablo A. González |
| author_sort |
Antonia Reyes |
| title |
Contribution of hypoxia inducible factor-1 during viral infections |
| title_short |
Contribution of hypoxia inducible factor-1 during viral infections |
| title_full |
Contribution of hypoxia inducible factor-1 during viral infections |
| title_fullStr |
Contribution of hypoxia inducible factor-1 during viral infections |
| title_full_unstemmed |
Contribution of hypoxia inducible factor-1 during viral infections |
| title_sort |
contribution of hypoxia inducible factor-1 during viral infections |
| publisher |
Taylor & Francis Group |
| publishDate |
2020 |
| url |
https://doaj.org/article/ed70e18c4a6a4787be7aeb11fc0b7f41 |
| work_keys_str_mv |
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