Paraneoplastic limbic encephalitis associated with lung cancer

Abstract Paraneoplastic limbic encephalitis (PLE) is a rare autoimmune neurological syndrome observed in lung cancer patients. We retrospectively investigated the clinical characteristics, treatment responses, and prognoses in 16 PLE patients who were subsequently diagnosed with lung cancer. Fifteen...

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Autores principales:	Kaini Shen, Yan Xu, Hongzhi Guan, Wei Zhong, Minjiang Chen, Jing Zhao, Longyun Li, Mengzhao Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed7170ea8d3b444993ed7001cb22c6df
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spelling	oai:doaj.org-article:ed7170ea8d3b444993ed7001cb22c6df2021-12-02T11:41:24ZParaneoplastic limbic encephalitis associated with lung cancer10.1038/s41598-018-25294-y2045-2322https://doaj.org/article/ed7170ea8d3b444993ed7001cb22c6df2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25294-yhttps://doaj.org/toc/2045-2322Abstract Paraneoplastic limbic encephalitis (PLE) is a rare autoimmune neurological syndrome observed in lung cancer patients. We retrospectively investigated the clinical characteristics, treatment responses, and prognoses in 16 PLE patients who were subsequently diagnosed with lung cancer. Fifteen patients initially presented with disturbance of consciousness, 13 with disorientation, and 12 with seizures. Thirteen patients had autoantibodies, including eight with gamma aminobutyric acid B receptor (GABABR) antibodies and eight with Hu antibodies. PET-CT revealed lung neoplasms in 13 patients, nine of whom exhibited abnormal metabolic activity in the temporal lobe and hippocampus. Fifteen cases were confirmed as limited-stage small cell lung cancer and one as stage IV large cell neuroendocrine carcinoma. Eleven patients received immunomodulatory therapy, and four showed neurological improvement, who all had antibodies against GABABR. Fifteen patients received chemotherapy, of which 14 maintained or improved their PLE status. The overall cancer response rate was 75%, and two-year overall survival was 74.7%. Our results suggest patients with GABAB encephalitis might respond better to immunotherapy than the classical PLE patients with anti-Hu antibodies. Anti-cancer treatment could further improve neurological symptoms. Lung cancer patients with PLE, especially those in limited stage, might have better outcome due to earlier diagnosis and prompt anti-cancer treatment.Kaini ShenYan XuHongzhi GuanWei ZhongMinjiang ChenJing ZhaoLongyun LiMengzhao WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kaini Shen Yan Xu Hongzhi Guan Wei Zhong Minjiang Chen Jing Zhao Longyun Li Mengzhao Wang Paraneoplastic limbic encephalitis associated with lung cancer
description	Abstract Paraneoplastic limbic encephalitis (PLE) is a rare autoimmune neurological syndrome observed in lung cancer patients. We retrospectively investigated the clinical characteristics, treatment responses, and prognoses in 16 PLE patients who were subsequently diagnosed with lung cancer. Fifteen patients initially presented with disturbance of consciousness, 13 with disorientation, and 12 with seizures. Thirteen patients had autoantibodies, including eight with gamma aminobutyric acid B receptor (GABABR) antibodies and eight with Hu antibodies. PET-CT revealed lung neoplasms in 13 patients, nine of whom exhibited abnormal metabolic activity in the temporal lobe and hippocampus. Fifteen cases were confirmed as limited-stage small cell lung cancer and one as stage IV large cell neuroendocrine carcinoma. Eleven patients received immunomodulatory therapy, and four showed neurological improvement, who all had antibodies against GABABR. Fifteen patients received chemotherapy, of which 14 maintained or improved their PLE status. The overall cancer response rate was 75%, and two-year overall survival was 74.7%. Our results suggest patients with GABAB encephalitis might respond better to immunotherapy than the classical PLE patients with anti-Hu antibodies. Anti-cancer treatment could further improve neurological symptoms. Lung cancer patients with PLE, especially those in limited stage, might have better outcome due to earlier diagnosis and prompt anti-cancer treatment.
format	article
author	Kaini Shen Yan Xu Hongzhi Guan Wei Zhong Minjiang Chen Jing Zhao Longyun Li Mengzhao Wang
author_facet	Kaini Shen Yan Xu Hongzhi Guan Wei Zhong Minjiang Chen Jing Zhao Longyun Li Mengzhao Wang
author_sort	Kaini Shen
title	Paraneoplastic limbic encephalitis associated with lung cancer
title_short	Paraneoplastic limbic encephalitis associated with lung cancer
title_full	Paraneoplastic limbic encephalitis associated with lung cancer
title_fullStr	Paraneoplastic limbic encephalitis associated with lung cancer
title_full_unstemmed	Paraneoplastic limbic encephalitis associated with lung cancer
title_sort	paraneoplastic limbic encephalitis associated with lung cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ed7170ea8d3b444993ed7001cb22c6df
work_keys_str_mv	AT kainishen paraneoplasticlimbicencephalitisassociatedwithlungcancer AT yanxu paraneoplasticlimbicencephalitisassociatedwithlungcancer AT hongzhiguan paraneoplasticlimbicencephalitisassociatedwithlungcancer AT weizhong paraneoplasticlimbicencephalitisassociatedwithlungcancer AT minjiangchen paraneoplasticlimbicencephalitisassociatedwithlungcancer AT jingzhao paraneoplasticlimbicencephalitisassociatedwithlungcancer AT longyunli paraneoplasticlimbicencephalitisassociatedwithlungcancer AT mengzhaowang paraneoplasticlimbicencephalitisassociatedwithlungcancer
_version_	1718395435234623488

Paraneoplastic limbic encephalitis associated with lung cancer

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