Predictors for success in renal denervation–a single centre retrospective analysis

Abstract Renal denervation (RDN) is one of the most frequently used invasive methods for the treatment of arterial hypertension. However, recent randomized sham-controlled studies raised concern about the efficacy and predictability of response. We retrospectively analyzed outcomes of patients, who...

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Autores principales:	Alexander Reshetnik, Christopher Gohlisch, Christian Scheurig-Münkler, Maximilian De Bucourt, Walter Zidek, Markus Tölle, Markus van der Giet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Single-center Retrospective Analysis Ambulatory Blood Pressure Monitoring (ABPM) Office SBP Baseline Office Arterial Stiffness Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed7380358eff42fab6b1be59ea102467
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spelling	oai:doaj.org-article:ed7380358eff42fab6b1be59ea1024672021-12-02T15:08:14ZPredictors for success in renal denervation–a single centre retrospective analysis10.1038/s41598-018-33783-32045-2322https://doaj.org/article/ed7380358eff42fab6b1be59ea1024672018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33783-3https://doaj.org/toc/2045-2322Abstract Renal denervation (RDN) is one of the most frequently used invasive methods for the treatment of arterial hypertension. However, recent randomized sham-controlled studies raised concern about the efficacy and predictability of response. We retrospectively analyzed outcomes of patients, who underwent RDN in our hypertension center between November 2010 and April 2014 and report here outcomes twelve months after procedure based on 24-hours ambulatory blood pressure monitoring. We defined ten-mm Hg decrease in office systolic blood pressure (SBP) as a cut-off for response and looked for possible predictors of this response using binary multiple regression analysis. 42 patients were included. Their mean age was 59.6 ± 9.2 years and 24% were female. Baseline office SBP and diastolic blood pressure (DBP) were 164.1 ± 20.3 and 91.8 ± 12.4 mm Hg respectively. Mean 24 h-SBP significantly decreased from 149.8 ± 13.3 mm Hg to 141.2 ± 14.6 mm Hg. Mean 24 h-DBP significantly decreased from 83.3 ± 11.7 mm Hg to 78.8 ± 11.2 mm Hg. A higher level of mean 24 h-DBP and office DBP was shown to be predictive for response in office BP and a higher level of mean 24 h-DBP for response in 24 h-SBP and 24 h-DBP. Further properly designed randomized trials are warranted to confirm this finding as well as further investigate the role of diabetes mellitus and arterial stiffness in RDN.Alexander ReshetnikChristopher GohlischChristian Scheurig-MünklerMaximilian De BucourtWalter ZidekMarkus TölleMarkus van der GietNature PortfolioarticleSingle-center Retrospective AnalysisAmbulatory Blood Pressure Monitoring (ABPM)Office SBPBaseline OfficeArterial StiffnessMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Single-center Retrospective Analysis Ambulatory Blood Pressure Monitoring (ABPM) Office SBP Baseline Office Arterial Stiffness Medicine R Science Q
spellingShingle	Single-center Retrospective Analysis Ambulatory Blood Pressure Monitoring (ABPM) Office SBP Baseline Office Arterial Stiffness Medicine R Science Q Alexander Reshetnik Christopher Gohlisch Christian Scheurig-Münkler Maximilian De Bucourt Walter Zidek Markus Tölle Markus van der Giet Predictors for success in renal denervation–a single centre retrospective analysis
description	Abstract Renal denervation (RDN) is one of the most frequently used invasive methods for the treatment of arterial hypertension. However, recent randomized sham-controlled studies raised concern about the efficacy and predictability of response. We retrospectively analyzed outcomes of patients, who underwent RDN in our hypertension center between November 2010 and April 2014 and report here outcomes twelve months after procedure based on 24-hours ambulatory blood pressure monitoring. We defined ten-mm Hg decrease in office systolic blood pressure (SBP) as a cut-off for response and looked for possible predictors of this response using binary multiple regression analysis. 42 patients were included. Their mean age was 59.6 ± 9.2 years and 24% were female. Baseline office SBP and diastolic blood pressure (DBP) were 164.1 ± 20.3 and 91.8 ± 12.4 mm Hg respectively. Mean 24 h-SBP significantly decreased from 149.8 ± 13.3 mm Hg to 141.2 ± 14.6 mm Hg. Mean 24 h-DBP significantly decreased from 83.3 ± 11.7 mm Hg to 78.8 ± 11.2 mm Hg. A higher level of mean 24 h-DBP and office DBP was shown to be predictive for response in office BP and a higher level of mean 24 h-DBP for response in 24 h-SBP and 24 h-DBP. Further properly designed randomized trials are warranted to confirm this finding as well as further investigate the role of diabetes mellitus and arterial stiffness in RDN.
format	article
author	Alexander Reshetnik Christopher Gohlisch Christian Scheurig-Münkler Maximilian De Bucourt Walter Zidek Markus Tölle Markus van der Giet
author_facet	Alexander Reshetnik Christopher Gohlisch Christian Scheurig-Münkler Maximilian De Bucourt Walter Zidek Markus Tölle Markus van der Giet
author_sort	Alexander Reshetnik
title	Predictors for success in renal denervation–a single centre retrospective analysis
title_short	Predictors for success in renal denervation–a single centre retrospective analysis
title_full	Predictors for success in renal denervation–a single centre retrospective analysis
title_fullStr	Predictors for success in renal denervation–a single centre retrospective analysis
title_full_unstemmed	Predictors for success in renal denervation–a single centre retrospective analysis
title_sort	predictors for success in renal denervation–a single centre retrospective analysis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ed7380358eff42fab6b1be59ea102467
work_keys_str_mv	AT alexanderreshetnik predictorsforsuccessinrenaldenervationasinglecentreretrospectiveanalysis AT christophergohlisch predictorsforsuccessinrenaldenervationasinglecentreretrospectiveanalysis AT christianscheurigmunkler predictorsforsuccessinrenaldenervationasinglecentreretrospectiveanalysis AT maximiliandebucourt predictorsforsuccessinrenaldenervationasinglecentreretrospectiveanalysis AT walterzidek predictorsforsuccessinrenaldenervationasinglecentreretrospectiveanalysis AT markustolle predictorsforsuccessinrenaldenervationasinglecentreretrospectiveanalysis AT markusvandergiet predictorsforsuccessinrenaldenervationasinglecentreretrospectiveanalysis
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Predictors for success in renal denervation–a single centre retrospective analysis

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