TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation
Mycobacterial cell wall lipids can drive immunoevasion, but underlying mechanisms are incompletely understood. Here the authors show TREM2 is a pattern recognition receptor that binds non-glycosylated mycolic acid-containing lipids and inhibits Mincle-induced anti-mycobacterial macrophage responses.
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Nature Portfolio
2021
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oai:doaj.org-article:ed7734d2af8e41d9835e7e52844329082021-12-02T14:25:15ZTREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation10.1038/s41467-021-22620-32041-1723https://doaj.org/article/ed7734d2af8e41d9835e7e52844329082021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22620-3https://doaj.org/toc/2041-1723Mycobacterial cell wall lipids can drive immunoevasion, but underlying mechanisms are incompletely understood. Here the authors show TREM2 is a pattern recognition receptor that binds non-glycosylated mycolic acid-containing lipids and inhibits Mincle-induced anti-mycobacterial macrophage responses.Ei’ichi IizasaYasushi ChumaTakayuki UematsuMio KubotaHiroaki KawaguchiMasayuki UmemuraKenji ToyonagaHideyasu KiyoharaIkuya YanoMarco ColonnaMasahiko SugitaGoro MatsuzakiSho YamasakiHiroki YoshidaHiromitsu HaraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ei’ichi Iizasa Yasushi Chuma Takayuki Uematsu Mio Kubota Hiroaki Kawaguchi Masayuki Umemura Kenji Toyonaga Hideyasu Kiyohara Ikuya Yano Marco Colonna Masahiko Sugita Goro Matsuzaki Sho Yamasaki Hiroki Yoshida Hiromitsu Hara TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation |
| description |
Mycobacterial cell wall lipids can drive immunoevasion, but underlying mechanisms are incompletely understood. Here the authors show TREM2 is a pattern recognition receptor that binds non-glycosylated mycolic acid-containing lipids and inhibits Mincle-induced anti-mycobacterial macrophage responses. |
| format |
article |
| author |
Ei’ichi Iizasa Yasushi Chuma Takayuki Uematsu Mio Kubota Hiroaki Kawaguchi Masayuki Umemura Kenji Toyonaga Hideyasu Kiyohara Ikuya Yano Marco Colonna Masahiko Sugita Goro Matsuzaki Sho Yamasaki Hiroki Yoshida Hiromitsu Hara |
| author_facet |
Ei’ichi Iizasa Yasushi Chuma Takayuki Uematsu Mio Kubota Hiroaki Kawaguchi Masayuki Umemura Kenji Toyonaga Hideyasu Kiyohara Ikuya Yano Marco Colonna Masahiko Sugita Goro Matsuzaki Sho Yamasaki Hiroki Yoshida Hiromitsu Hara |
| author_sort |
Ei’ichi Iizasa |
| title |
TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation |
| title_short |
TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation |
| title_full |
TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation |
| title_fullStr |
TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation |
| title_full_unstemmed |
TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation |
| title_sort |
trem2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ed7734d2af8e41d9835e7e5284432908 |
| work_keys_str_mv |
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1718391461266849792 |