Pleiotropic effects between cardiovascular disease risk factors and measures of cognitive and physical function in long-lived adults

Abstract Cardiovacular disease (CVD) is the leading cause of death among older adults and is often accompanied by functional decline. It is unclear what is driving this co-occurrence, but it may be behavioral, environmental and/or genetic. We used a family-based study to estimate the phenotypic and...

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Autores principales:	Julia J. Yudkovicz, Ryan L. Minster, Emma Barinas-Mitchell, Kaare Christensen, Mary Feitosa, Megan S. Barker, Anne B. Newman, Allison L. Kuipers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed776ae3115142499fc64d38c96485bc
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spelling	oai:doaj.org-article:ed776ae3115142499fc64d38c96485bc2021-12-02T17:41:13ZPleiotropic effects between cardiovascular disease risk factors and measures of cognitive and physical function in long-lived adults10.1038/s41598-021-97298-02045-2322https://doaj.org/article/ed776ae3115142499fc64d38c96485bc2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97298-0https://doaj.org/toc/2045-2322Abstract Cardiovacular disease (CVD) is the leading cause of death among older adults and is often accompanied by functional decline. It is unclear what is driving this co-occurrence, but it may be behavioral, environmental and/or genetic. We used a family-based study to estimate the phenotypic and shared genetic correlation between CVD risk factors and physical and cognitive functional measures. Participants (n = 1,881) were from the Long Life Family Study, which enrolled families based on their exceptional longevity (sample mean age = 69.4 years, 44% female). Cardiovascular disease risk factors included carotid vessel measures [intima-media thickness and inter-adventitial diameter], obesity [body mass index (BMI) and waist circumference], and hypertension [systolic and diastolic blood pressures]. Function was measured in the physical [gait speed, grip strength, chair stand] and cognitive [digital symbol substitution test, retained and working memory, semantic fluency, and trail making tests] domains. We used SOLAR to estimate the genetic, environmental, and phenotypic correlation between each pair adjusting for age, age2, sex, field center, smoking, height, and weight. There were significant phenotypic correlations (range \|0.05–0.22\|) between CVD risk factors and physical and cognitive function (all P < 0.05). Most significant genetic correlations (range \|0.21–0.62\|) were between CVD risk factorsand cognitive function, although BMI and waist circumference had significant genetic correlation with gait speed and chair stand time (range \|0.29–0.53\|; all P < 0.05). These results suggest that CVD risk factors may share a common genetic-and thus, biologic-basis with both cognitive and physical function. This is particularly informative for research into the genetic determinants of chronic disease.Julia J. YudkoviczRyan L. MinsterEmma Barinas-MitchellKaare ChristensenMary FeitosaMegan S. BarkerAnne B. NewmanAllison L. KuipersNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julia J. Yudkovicz Ryan L. Minster Emma Barinas-Mitchell Kaare Christensen Mary Feitosa Megan S. Barker Anne B. Newman Allison L. Kuipers Pleiotropic effects between cardiovascular disease risk factors and measures of cognitive and physical function in long-lived adults
description	Abstract Cardiovacular disease (CVD) is the leading cause of death among older adults and is often accompanied by functional decline. It is unclear what is driving this co-occurrence, but it may be behavioral, environmental and/or genetic. We used a family-based study to estimate the phenotypic and shared genetic correlation between CVD risk factors and physical and cognitive functional measures. Participants (n = 1,881) were from the Long Life Family Study, which enrolled families based on their exceptional longevity (sample mean age = 69.4 years, 44% female). Cardiovascular disease risk factors included carotid vessel measures [intima-media thickness and inter-adventitial diameter], obesity [body mass index (BMI) and waist circumference], and hypertension [systolic and diastolic blood pressures]. Function was measured in the physical [gait speed, grip strength, chair stand] and cognitive [digital symbol substitution test, retained and working memory, semantic fluency, and trail making tests] domains. We used SOLAR to estimate the genetic, environmental, and phenotypic correlation between each pair adjusting for age, age2, sex, field center, smoking, height, and weight. There were significant phenotypic correlations (range \|0.05–0.22\|) between CVD risk factors and physical and cognitive function (all P < 0.05). Most significant genetic correlations (range \|0.21–0.62\|) were between CVD risk factorsand cognitive function, although BMI and waist circumference had significant genetic correlation with gait speed and chair stand time (range \|0.29–0.53\|; all P < 0.05). These results suggest that CVD risk factors may share a common genetic-and thus, biologic-basis with both cognitive and physical function. This is particularly informative for research into the genetic determinants of chronic disease.
format	article
author	Julia J. Yudkovicz Ryan L. Minster Emma Barinas-Mitchell Kaare Christensen Mary Feitosa Megan S. Barker Anne B. Newman Allison L. Kuipers
author_facet	Julia J. Yudkovicz Ryan L. Minster Emma Barinas-Mitchell Kaare Christensen Mary Feitosa Megan S. Barker Anne B. Newman Allison L. Kuipers
author_sort	Julia J. Yudkovicz
title	Pleiotropic effects between cardiovascular disease risk factors and measures of cognitive and physical function in long-lived adults
title_short	Pleiotropic effects between cardiovascular disease risk factors and measures of cognitive and physical function in long-lived adults
title_full	Pleiotropic effects between cardiovascular disease risk factors and measures of cognitive and physical function in long-lived adults
title_fullStr	Pleiotropic effects between cardiovascular disease risk factors and measures of cognitive and physical function in long-lived adults
title_full_unstemmed	Pleiotropic effects between cardiovascular disease risk factors and measures of cognitive and physical function in long-lived adults
title_sort	pleiotropic effects between cardiovascular disease risk factors and measures of cognitive and physical function in long-lived adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed776ae3115142499fc64d38c96485bc
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Pleiotropic effects between cardiovascular disease risk factors and measures of cognitive and physical function in long-lived adults

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